Mechanisms of bronchial asthma control disturbance in using 2-agonists
https://doi.org/10.20538/1682-0363-2006-1-67-72
Abstract
Despite exclusively high clinical efficacy of 2-agonists in bronchospasm, their regular using is associated with increased level of bronchial asthma control and the development of severe and life-threatening states which in turn is associated with increasing bronchial hyper-reactivity, development of partial tolerance, increased allergic load and masking of the disease aggravation. Deve- lopment of tolerance to 2-agonists and increasing sensibility of bronchi to bronchoconstrictive stimuli are based on specific mecha-nisms including desensitization of 2-adrenoreceptor, increasing expression of C phospholipase and mechanisms associated with gene AP variants which are not studied enough.
Keywords
616.248:615.234
About the Authors
N. V. Vas'kovsky
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
Ye. S. Koulikov
Сибирский государственный медицинский университет, г. Томск
Russian Federation
Russian Federation
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For citations:
Vas'kovsky N.V., Koulikov Ye.S. Mechanisms of bronchial asthma control disturbance in using 2-agonists. Bulletin of Siberian Medicine. 2006;5(1):67-72. (In Russ.) https://doi.org/10.20538/1682-0363-2006-1-67-72
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