THE ROLE OF TUMOR NECROSIS FACTOR-α G–308A, INTERLEUKIN-1β C–511T AND INTERLEUKIN-10 G–1082A GENE POLYMORPHISMS IN THE DEVELOPMENT OF SLOWLYRESOLVED COURSE OF COMMUNITY-ACQUIRED PNEUMONIA
https://doi.org/10.20538/1682-0363-2013-6-54-61
Abstract
Purpose: To study the distribution of genotypes and alleles tumor necrosis factor-α G–308A, interleukin1β C–511T, interleukin-10 G–1082A in patients with slowlyresolved pneumonia and their association with clinical and radiologicalfeatures of the disease.
Materials and Methods: We investigated 89 patients with community-acquired pneumonia, of which 37 people had a slowlyresolving course of the disease.The genotype distribution of studied polymorpisms corresponded the Hardy–Weinberg equilibrium.
Results: We determined that the tumor necrosis factor-α G–308A and interleukin-10 G–1082A gene polymorphisms were associated with the long course of pneumonia. Slow resolution of the disease in patients who are carriers of GA and AA genotypes of tumor necrosis factor-α contributed to a severe course. The intensity of inflammation in these patients was reflected in the high rates of erythrocyte sedimentation rate and C-reactive protein. Prolonged duration in patients who are carriers of GG genotype of IL-10 was associated with significant clinical and laboratory manifestations at onset of the disease and more frequent development of pleural effusion. The frequencies of alleles and genotypes of interleukin-1β in observed patients did not differ.
Conclusions: The data can be used for prognosis of slowlyresolved pneumonia
About the Authors
V. I. Sovalkin
Omsk State Medical Academy, Omsk
Russian Federation
Sovalkin Valery I.
Russian Federation
Sovalkin Valery I.
Ye. G. Pomorgaylo
Omsk State Medical Academy, Omsk
Russian Federation
Pomorgaylo Yelena G.
Russian Federation
Pomorgaylo Yelena G.
O. N. Sabitova
Omsk State Medical Academy, Omsk
Russian Federation
Sabitova Olga N.
Russian Federation
Sabitova Olga N.
Ye. P. Podgurskaya
Regional Clinical Hospital, Omsk
Russian Federation
Podgurskaya Yelena P.
Russian Federation
Podgurskaya Yelena P.
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Review
For citations:
Sovalkin V.I., Pomorgaylo Ye.G., Sabitova O.N., Podgurskaya Ye.P. THE ROLE OF TUMOR NECROSIS FACTOR-α G–308A, INTERLEUKIN-1β C–511T AND INTERLEUKIN-10 G–1082A GENE POLYMORPHISMS IN THE DEVELOPMENT OF SLOWLYRESOLVED COURSE OF COMMUNITY-ACQUIRED PNEUMONIA. Bulletin of Siberian Medicine. 2013;12(6):54-61. (In Russ.) https://doi.org/10.20538/1682-0363-2013-6-54-61
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