Lipid-laden alveolar macrophages in induced sputum in patients with gastroesophageal reflux disease
https://doi.org/10.20538/1682-0363-2006-4-136-139
Abstract
The aim of the study was to evaluate the diagnostic role of a lipid index of macrophages in induced sputum as a marker of aspiration of acidic gastric contents. 17 patients with the diagnosis of gastroesophageal reflux disease (GERD) and 10 healthy volunteers without any chronic digestive disorder were examined. In the group of patients with GERD, the maximal number of cells with positive reaction to lipids (31,70 ± 17,55) and maximal lipid index (45,06 ± 17,15), exceeding the control value five times, were found ( р < 0,05). The detection of lipid-laden alveolar macrophages in induced sputum can become a screenings method for diagnostics of gastroesophageal reflux. This requires the further investigations to clear up its causes.
About the Authors
L. I. Volkova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
O. A. Anichkina
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
I. V. Sukhodolo
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
R. I. Pleshko
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
V. S. Bogomyagkov
Городская больница № 3
Russian Federation
Russian Federation
References
1. Авдеев С.Н., Анаев Э.Х., Чучалин А.Г. Применение метода индуцированной мокроты для оценки интенсивности воспаления дыхательных путей // Пульмонология. 1998. № 2. С. 81—86.
2. Гастроэзофагеальная рефлюксная болезнь: клиника, диагностика, лечение [Электронный ресурс] / Под ред. А.В. Калинина. Электрон. дан. Режим доступа: http:// www.nedug.ru.
3. Иванова О.В., Исаков В.А., Морозов С.В. и др. Внепищеводные проявления гастроэзофагеальной рефлюксной болезни // Болезни органов пищеварения. 2004. № 2.
4. Лабораторные методы исследования в клинике: Справочник / Под ред. В.В. Меньшикова. М.: Медицина, 1987. 365 с.
5. Bandla H., Davis S., Hopkins N. Lipoid pneumonia: a silent complication of mineral oil aspiration // Pediatrics. 1999. V. 103. P. 19—22.
6. Carney I.K., Gibson P.G., Muree-Allen K. et al. A systemic evaluation of mechanisms in chronic cough // Am. J. Respir. Crit. Care. Med. 1997. V. 156. P. 211—216.
7. Colombo J.L. Pulmonary aspiration and lipid-laden macrophages: in search of gold (standards) // Pediatric Pulmonology. 1999. V. 28. P. 79—82.
8. Colombo J.L., Hallberg T.K. Recurrent aspiration in children: lipid—laden alveolar macrophage quantitation // Pediatr. Pulmonol. 1987. V. 3. Р. 86—89.
9. Corwin R.W., Irwin R.S. The lipid-laden alveolar macrophages as a marker of aspiration in parenchymal lung disease // Am. Rev. Respir. Dis. 1985. V. 132. P. 576—581.
10. Godeau B., Schaeffer A., Bachir D. et al. Bronchoalveolar lavage in adult sickle cell patients with acute chest syndrome: value for diagnostic assessment of fat embolism // Am. J. Respir. Crit. Care Med. 1996. V. 153. P. 1691—1696.
11. Kazachkov M.Y., Muhlebach M.S., Livasy C.A., Noah T.L. Lipid-laden macrophage index and inflammation in bronchoalveolar lavage fluids in children // Eur. Respir. J. 2001. V. 18. 790—795.
12. Langston C., Pappin A. Lipid-laden alveolar macrophages as an indicator of aspiration pneumonia // Arch. Pathol. Lab. Med. 1996. V. 120. P. 326—324.
13. Nissabaum E., Maggi J.C., Mathis R., Galant S.P. Association of lipid-laden alveolar macrophages and gastroesophageal reflux in children // J. Pediatr. 2002. V. 110. Р. 190—194.
14. Okan E., Fan L.L., Giuseppe C. Novel diagnostic method for pulmonary aspiration in a murine model // Am. J. Respir. Crit. Care. Med. 2000. V. 161. Р. 622—626.
15. Parameswaran K., Anvari M., Efthimiadis A. at al. Lipid-laden macrophages in induduced sputum are a marker of oropharingeal reflux and possible gastric aspiration // Eur. Respir J. 2000. V. 16. P. 1119—1122.
16. Vichinsky E., Williams R., Das M. et al. Pulmonary fat embolism: a distinct cause of severe acute chest syndrome in sickle cell anemia // Blood. 1994. V. 83. P. 3107—3112.
Review
For citations:
Volkova L.I., Anichkina O.A., Sukhodolo I.V., Pleshko R.I., Bogomyagkov V.S. Lipid-laden alveolar macrophages in induced sputum in patients with gastroesophageal reflux disease. Bulletin of Siberian Medicine. 2006;5(4):136-139. (In Russ.) https://doi.org/10.20538/1682-0363-2006-4-136-139
Views:
708
Email this article 