BILE LITHOGENICITY IN PATIENTS WITH TYPE 2 DIABETES AND ITS CORRECTION
https://doi.org/10.20538/1682-0363-2014-2-82-87
Abstract
We conducted a study to assess the bile lithogenicity in patients with type 2 diabetes mellitus (DM). We have found increased levels of cholesterol both in the gallbladder and hepatic bile. The study showed a decrease of cholatocholesterol coefficient (HHC), increase of lithogenic index Thomas–Hofmann and Rubens in all patients with type 2 diabetes, particularly in the gallbladder bile, indicating the colloidal destabilization of bile and an increased tendency to stone formation. Especially pronounced lithogenicity bile in patients with type 2 diabetes was associated with age in patients over 40 years of age and concomitant overweight or obese (BMI > 27 kg/m2). After a course of ursodeoxycholic acid (UDCA) at a dose of 15 mg/kg of body weight per day for 2.5–3 months was reduced lithogenicity gallbladder bile in patients with type 2 diabetes mellitus when the duration of disease was up to 5 years in 1.3 times, more than 5 years – in 1.5 times, more than 10 years – 1.7 times according to the index Thomas–Hofmann and Rubens.
About the Authors
O. A. Pavlenko
Siberian State Medical University, Tomsk
Russian Federation
Pavlenko Olga A.
Russian Federation
Pavlenko Olga A.
Ye. N. Babich
Institute of Cardiology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Babich Yelena N.
Russian Federation
Babich Yelena N.
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Review
For citations:
Pavlenko O.A., Babich Ye.N. BILE LITHOGENICITY IN PATIENTS WITH TYPE 2 DIABETES AND ITS CORRECTION. Bulletin of Siberian Medicine. 2014;13(2):82-87. (In Russ.) https://doi.org/10.20538/1682-0363-2014-2-82-87
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