The mild cranial traumas and autoimmune affection of the nervous system: dynamic of the indexes of the B-cells activation in patients during the rehabilitation period

Abstract

The aim was to study the indexes of the autoimmune affection of the nervous system in patients with rheumatoid arthritis (RA) after mild cranial traumas (CT). Under the observation there were 16 patients with neurological signs of RA, got mild CT. The group of compare consisted of 30 patients with RA and the nervous system lesions but without CT in the histories of lives. 30 healthy people were in the control group. The blood for the investigations was got 6 times from patients of the main group: on the 2^nd, 15^th, 30^th, 60^th, 90^th, and 120^th days after the CT. The autoimmune affection of the nervous system was diagnosed by the help of definition of the cerebrolysin-dependent activation of the B-lymphocytes by the method of quantitive cytophluorimetry. It was found that B-cells of RA patients with the nervous system lesions were sensitized to the nervous tissue. Even mild CT of the RA patients noticeably raises the activity of the immune system pointed on the tissue of the CNS. Usage of the standard treatment could not prevent such changes which were the brightest to the 15^th day after CT.