Cell immunity at pregnant women with autoimmune thyroiditis and gestosis
https://doi.org/10.20538/1682-0363-2002-1-57-62
Abstract
In a prospective study the group of 60 women with AIT and thyroidological uneventful control women, matched for age and parity (n = 30) were tested at 12 and 32 weeks gestation for percentages of peripheral blood lymphocyte subsets (CD3, CD4, CD8, CD16, HLA-DR major histocompatibility complex (MHC)-class II), IL-2, IFN-gamma, TPO-Abs, TSH and thyroxin.
Twenty five pregnant women with AIT (41,7%) developed preeclampsia (against 16,7% in control). Pregnancyrelated CMI alterations consisted of low percentages of CD16+ NK cells and all subpopulations of T-cells at 12 weeks gestation. The development of preeclampsia in women with AIT was accompanied with increasing percentage of HLADR+ T- lymphocytes. The high levels of TPO-Abs and activated T-lymphocytes in pregnant women with autoimmune thyroiditis has been suggested as a predictor for later preeclampsia development.
About the Authors
A. Sh. Makhmuthodzhayev
Сибирский государственный медицинский университет;
Роддом 4
Russian Federation
Russian Federation
L. M. Ogorodova
Сибирский государственный медицинский университет;
Роддом 4
Russian Federation
Russian Federation
I. D. Evtushenko
Сибирский государственный медицинский университет;
Роддом 4
Russian Federation
Russian Federation
A. V. Holopov
Сибирский государственный медицинский университет;
Роддом 4
Russian Federation
Russian Federation
E. L. Timoshina
Сибирский государственный медицинский университет;
Роддом 4
Russian Federation
Russian Federation
E. V. Makhmuthodzhayeva
Сибирский государственный медицинский университет;
Роддом 4
Russian Federation
Russian Federation
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Review
For citations:
Makhmuthodzhayev A.Sh., Ogorodova L.M., Evtushenko I.D., Holopov A.V., Timoshina E.L., Makhmuthodzhayeva E.V. Cell immunity at pregnant women with autoimmune thyroiditis and gestosis. Bulletin of Siberian Medicine. 2002;1(1):57-62. (In Russ.) https://doi.org/10.20538/1682-0363-2002-1-57-62
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