MOLECULAR GENETIC STUDIES OF COMORBIDITY
https://doi.org/10.20538/1682-0363-2015-6-94-102
Abstract
This review focuses at the problem of the genetic basis of comorbidity. We discuss the concepts and terms relating to combinations of diseases. The guidelines of the study of comorbidity using modern high throughput methods and approaches of genetics, molecular biology and bioinformatics are designated. In this review we present results of studies showing genetic specificity for the combined phenotypes dif-ferent from the isolated disease, we considergene-gene and gene-environment interactions in comorbidity. We also discuss the role of single nucleotide polymorphisms and structural genome variations in the
development of comorbidity. Own results of researching shared genes of inversely comorbid diseases like as bronchial asthma and
tuberculosis are presented.
About the Authors
Ye. Yu. Bragina
Research Institute for Medical Genetics, Tomsk, Russian Federation
Russian Federation
Research Institute for Medical Genetics, Tomsk, Russian Federation
Russian Federation
Research Institute for Medical Genetics, Tomsk, Russian Federation
M. B. Freidin
Research Institute for Medical Genetics, Tomsk, Russian Federation
Russian Federation
Research Institute for Medical Genetics, Tomsk, Russian Federation
Russian Federation
Research Institute for Medical Genetics, Tomsk, Russian Federation
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Review
For citations:
Bragina Ye.Yu., Freidin M.B. MOLECULAR GENETIC STUDIES OF COMORBIDITY. Bulletin of Siberian Medicine. 2015;14(6):94-102. (In Russ.) https://doi.org/10.20538/1682-0363-2015-6-94-102
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