The role of herpes-virus infection and mixed infection in atopy
https://doi.org/10.20538/1682-0363-2002-3-30-39
Abstract
An observative study of infectionary risk factors (simple herpes virus, toxoplasm, cytomatagalovirus, helminths, candida, staphylocoque, listeriosis) in reagine immunopathological reactions development has been undertaken in a basic group of 3183 patients. In the study the «case-control» method of populate investigation was being used. The patients of representative sample (293 persons) with atopic diseases have been investigated for specific antibodies for these diseases and IgE antibodies. The study results in a statistically trustworthy association between the simple herpes infection, cytomatagalovirus, helminths and candida infections, the IgE hyperproduction, and a numeral increase both of patients with combined forms of atopy and of accompanying diseases. The aforesaid makes us refer these infections to the risk factors causing infavourable development of atopic diseases. In the contrary, helminths infection in atopic patients correlates with decrease of IgE production that in general approves the so-called «hygienic hypothesis».
About the Authors
L. M. Ogorodova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
O. V. Kozina
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
References
1. Балаболкин И.И.//Аллергические заболевания у детей на современном этапе/Consilium Medicum. 1999. Т. 1. № 6. С. 251-253.
2. Cookson WOCM. Asthma: an epidemic in the absence of infection?/WOCM Cookson, M.F. Moffatt//Science. 1997. V. 275. P. 41-42.
3. Kay A.B. Allergy and Allergic Diseases/A.B. Kay. Oxford: Blackwell Sci. 1997. V. 1. P. 666.
4. Martinez F.D. Role of microbial burden in aetiology of allergy and asthma/F.D. Martinez, F. Rosmini, L. Ferrigno. et al.//Lancet. 1999. V. 354. Suppl 2. P. 112-115.
5. Material inveritance of atopic IgE responsiveness on chromosome 11q/WOCM. Cookson, R.P. Yong, A.V. Sandford et al.//Lancent. 1992. ‹ 8816. Р. 381-384.
6. Matricardi P.M. Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus/P.M. Matricardi, F. Rosmini, L. Ferrigno et al.//BMG. 1997. V. 314.7086. P. 999-1003.
7. Measles and atopy in Guinea-Bissau/S.O. Shaheen, P. Aaby, A.J. Hall et. al.//Lancet. 1996. V. 347. P. 1792-1796.
8. Patrick G. Holt Parasites, atopy, and the hygiene hypothesis: resolution of a paradox?/G. Patrick//Lancet. 2000. V. 356. ‹ 9243. P. 1699-1701.
9. Von Hertzen L.C. Puzzling associations between childhood infections and the later occurrence of asthma and atopy/L.C. von Hertzen//Ann. Acad. Med. 2000. V. 32. № 6. P. 397-400.
10. Woolcock A.J. Evidence for the increase in asthma wordwide/A.J. Woolcock, J.K. Peat//Ciba Foundation, Rising Trends in Asthma. Chichester, Wiley, 1997. P. 122-134.
Review
For citations:
Ogorodova L.M., Kozina O.V. The role of herpes-virus infection and mixed infection in atopy. Bulletin of Siberian Medicine. 2002;1(3):30-39. (In Russ.) https://doi.org/10.20538/1682-0363-2002-3-30-39
Views:
412
Email this article 