Airway hyperresponsiveness in bronchial asthma: pathogenesis basics
https://doi.org/10.20538/1682-0363-2002-4-65-74
Abstract
Bronchial asthma has three main components: persistent bronchial inflammation, reversible bronchial obstruction and bronchial hyperresponsiveness to nonspecific triggers. Airway hyperresponsiveness is a complex phenomenon that develops upon the influence of chronic inflammation, high total IgE, changes in bronchial smooth muscle cells functioning, structural changes in bronchial wall and disturbances in neural regulation of bronchial tone.
About the Authors
I. A. Deyev
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
I. V. Petrova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
E. G. Karmalita
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
F. I. Petrovsky
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
L. M. Ogorodova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
References
1. Абросимов В.Н., Порядин В.Г. Воспаление и гиперреактивность дыхательных путей при бронхиальной астме. Тер. арх. 1994.
2. Гавалов С.М., Казначеева Л.Ф. Новые концепции рецидивов после острых бронхолегочных заболеваний у детей, МРЖ, P.V. 1983. С. 19.
3. Гавалов С.М. Синдром гиперреактивности бронхов и его клинические разновидности//Консилиум. № 1. 1999. С. 3-11.
4. Савельев Б.П., Реутова В.С., Ширяева И.С. Гиперреактивность бронхов по ингаляционному тесту с гистамином у детей и подростков//Медицинский научный и учебно-методический журнал. № 5. 2001. С. 121-146.
5. Черняк А.В., Савельев Б.П., Реутова В.С., Ширяева И.С. Гиперреактивность бронхов по ингаляционному тесту с гистамином у детей и подростков. Медицинский научный и учебно-методический журнал. 2001. № 5. С. 121-146.
6. Ackerman V., Marini M., Vittori E., Bellini A., Vassali G., Mattoli S. Detection of cytokines and their cell sources in bronchial biopsy specimens from asthmatic patients//Chest. 1994. V. 105.
7. Avital A., Springer C., Bar-Yishay E., Godfrey S. Adenosine, methacholine, and exercise challenges in children with asthma or paediatric chronic obstructive pulmonary disease//Thorax. 1995. V. 50.
8. Bahna S.L., Heiner D.C., Myhre B.A. Immunoglobulin E pattern in cigarette smokers//Allergy. 1983. V. 38.
9. Barnes P.J. New cocpts in the pathogenesis of bronchial responsiveness and asthma/P.J. Barnes//J. Allergy Clin. Immunol. 1989. V. 83. P. 1013-1026.
10. Berline G., Barnes N. No role for No in asthma?//Lancet. 2000. V. 335. P. 1029-1030.
11. Bradley B.L., Azzawi M., Jacobson M., AssoufiB., Collins J.V., Irani A.M. et al. Eosinophils, Tlymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness//J. Allergy Clin. Immunol. 1991. V. 88.
12. Cain H. Bronchoprovocation Testing//Clinics in Chest Medicine. 2001. V. 22.
13. Corrigan C.J. Kay A.B. T cells and eosinophils in the pathogenesis of asthma//Immunol. Today. 1992. V. 13.
14. De Sanctis G.T., Daheshia M., Daser A. Genetics of airway hyperresponsiveness//J. of Allergy and Clinical Immunology. 2001. V. 108. № 1.
15. Gao Y., Vanhoutte P.M. epithelium acts as a modulator and a diffusion barrier in the responses of canine airway smooth muscle//J. Appl. Physiol. 1994. V. 76. № 5. P. 1843-1847.
16. Global strategy for asthma management and prevention. National Institutes of Health; National Heart, Lung and Blood Institute, 1995.
17. Guidelines for the Diagnosis and Management of Asthma. National Asthma Education and Prevention Program, National Heart, Lung and Blood Institute, National Institute of Health, 1997.
18. Haahtela T. Airway remodelling takes place in asthmawhat are the clinical implications?//Clin. Exp. Allergy. 1997. V. 27. № 3.
19. Hakonarson H., Maskeri N., Carter C., Grunstein M.M. Regulation of Th1-and Th2-type cytokine expression and action in atopic asthmatic sensitized airway smooth muscle//J. Clin. Invest. 1999. V. 103.
20. Hirst S.J. Airway smooth muscle cell culture: application to studies of airway wall remodelling and phenotype plasticity in asthma//Eur. Respir. J. 1996. V. 9.
21. Huber H.L., Koessler K.K. The pathology of bronchial asthma//Arch. Intern. Med. 1922. V. 30.
22. Jacoby D.B., Costello R.M., Fryer A.D. Eosinophil recruitment to the airway nerves//J. of Allergy and Clinical Immunology. 2001. V. 107. № 2.
23. Jensen E.J., Pedersen B., Schmidt E., Dahl R. Serum IgE in nonatopic smokers, nonsmokers, and recent exsmokers: relation to lung function, airway symptoms, and atopic predisposition//J. Allergy Clin. Immunol. 1992. V. 90.
24. Johnson S.R., Knox A.J. Synthetic functions of airway smooth muscle in asthma//Trends Pharmacol. Sci. 1997. V. 18.
25. Joos G., Pauwels R., Van der S.M. Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects//Thorax. 1987. V. 42.
26. Kumagai K., Ohno I., Okada S., Ohkawara Y., Suzuki K., Shinya T. et al. Inhibition of matrix metalloproteinases prevents allergen-induced airway inflammation in a murine model of asthma//J. Immunol. 1999. V. 162.
27. Lambert R.K., Wiggs B.R., Kuwano K., Hogg J.C., Pare P.D. Functional significance of increased airway smooth muscle in asthma and COPD//J. Appl. Physiol. 1993. V. 81.
28. Laprise C., Laviolette M., Boutet M., Boulet L-P. Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodeling//Eur. Respir. J. 1999. V. 14.
29. Lazaar A.L., Albelda S.M./, Pilewski J.M., Brennan B., Pure E., Panettieri R.A. // T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis // J. Exp. Med. 1994. V. 180.
30. Nadel J.A. Some epithelial metabolic factors affecting airway smooth muscle//Am. Rev. Respir. Dis. 1988. V. 138. № 3. Pt. 2. P. 22-23.
31. O'Hickey S.P., Arm J.P., Rees P.J., Spur B.W., Lee T.H. The relative responsiveness to inhaled leukotriene E4, methacholine and histamine in normal and asthmatic subjects//Eur. Respir. J. 1988. V. 1.
32. Platts-Mills T.A. Mechanisms of bronchial reactivity: the role of immunoglobulin E//Am. Rev. Respir. Dis. 1992. V. 145.
33. Prausnitz C., Küstner H. Studien der Überempfindlichkeit//Centralb. Bakteriolog. 1 Abt. Orig. 1921. V. 86.
34. Robinson D.S., Hamid Q., Ying S., Tsicopoulos A., Barkans J., Bentley A.M. et al. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma//N. Engl. J. Med. 1992. V. 326.
35. Schmidt D., Rabe K.F. Immune mechanisms of smooth muscle hyperreactivity in asthma//J. of Allergy and Clinical Immunology. 2000. V. 105. № 4.
36. Schmidt D., Watson N., Rühlmann E., Magnussen H., Rabe K.F. Serum IgE levels predict human airway reactivity in vitro//Clin. Exp. Allergy. 2000. V. 30.
37. Sears M.R. et al. Relation between Airway Responsiveness and lgE in Children with Asthma and in Apparantly Normal Children//N. Engl. J. Meet. 1991. V. 325. P. 1067-1071.
38. Shi H.Z., Deng J.V., Xu H., Nong Z.X., Xiao C.Q., Liu Z.M. et al. Effect of inhaled interleukin-4 on airway hyperreactivity in asthmatics//Am. J. Respir. Crit. Care Med. 1998. V. 157.
39. Sterk P.J., Bel E.H. The shape of the dose-response curve to inhaled bronchoconstrictor agents in asthma and in chronic obstructive pulmonary disease//Am. Rev. Respir. Dis. 1991.V. 143.
40. Sterk P.J., Timmers M.C., Dijkman J.H. Maximal airway narrowing in humans in vivo: histamine compared with methacholine//Am. Rev. Respir. Dis. 1986. V. 134.
41. Sunyer J., Antó J.M., Kogevinas M., Soriano J.B., Tobias A., Munoz A. Smoking and bronchial responsive ness in nonatopic and atopic young adults//Thorax. 1997. V. 52.
42. Vignola A.M., Kips J., Bousquet J. Tissue remodeling as a feature of persistent asthma//J. of Allergy and Clinical Immunology. 2000. V. 105. № 6.
43. Warner J.O., Pohunek P., Marguet C., William R., Roche J.B. Epidemiology and genetics of asthma//J. of Allergy and Clinical Immunology. 2000. V. 105. № 2.
44. Woolcock A.J., Salome C.M., Yan K. The shape of the dose-response curve to histamine in asthmatic and normal subjects//Am. Rev. Respir. Dis. 1984. V. 130.
45. Ying S., Durham S.R., Corrigan C.J., Hamid Q., Kay A.B. Phenotype of cells expressing mRNA for Th2-type (interleukin 4 and interleukin 5) and Th1-type (interleukin 2 and interferon g) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects//Am. J. Respir. Cell. Mol. Biol. 1995. V. 12.
Review
For citations:
Deyev I.A., Petrova I.V., Karmalita E.G., Petrovsky F.I., Ogorodova L.M. Airway hyperresponsiveness in bronchial asthma: pathogenesis basics. Bulletin of Siberian Medicine. 2002;1(4):65-74. (In Russ.) https://doi.org/10.20538/1682-0363-2002-4-65-74
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