SCREENING METHOD OF THE DYSPLASIA OF THE CONNECTIVE TISSUE IN ADOLESCENTS
https://doi.org/10.20538/1682-0363-2016-2-35-44
Abstract
ABSTRACT Aim of the study is to develop the diagnostic checklist based on the incidence and significance analysis of the external features of the dysplasia of the connective tissue (DCT) for its screening and assessment of its prevalence in the adolescents’ population.
Materials and methods.110 adolescents (aged from 10 to 14 years) were examined, 81 of them had the dysplasia of the connective tissue (the first group). The second group was presented by 29 adolescents without DCT. The presence and degree of manifestation of DCT were established according to the criterions of Kadurina T. I., Gorbunova V.N. (2009), Т. Milkovska–Dimitrova (1987). There were the physical, laboratory and instrumental examination. Statistical processing of the results was carried out using Statistica 6.0 program and IBM SPSS Statistics 20.0. The diagnostic efficiency of the developed checklist was appreciated by means of the receiver operating characteristic curve (ROC curve).
Results. The frequent occurrence of the DCT’s external features in adolescents was identified. The diagnostic checklist was developed. It was consisted of 12 items with illustrations, allowing readily identification of the dysplastic phenotype presence with diagnostic sensitivity 81.5% and specificity 79.3%. This checklist can be recommended as for the population studies, as for screening about DCT in adolescents during the primary outpatient pediatrician attendance. In the positive result of the screening it is necessary the further checkup to detect the organ changes and diagnosis updating.
About the Authors
G. Y. Kalaeva
Clinical Center of the Miners’ Health Protection, Leninsk-Kuznetsky
Russian Federation
Russian Federation
O. I. Khokhlova
Clinical Center of the Miners’ Health Protection, Leninsk-Kuznetsky
Russian Federation
Russian Federation
I. A. Deev
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
References
1. Arsent’ev V.G., Shabalov N.P. Dysplasia of the connective tissue in children as the constitutional base of the multiple organs disorders: classification problems and diagnosis criterions // Voprosy prakticheskoy pediatrii, 2011, vol. 6, no 5. pp. 59–65 (in Russian).
2. Viktorova I.A., Nechaeva G.I., Konev V.P. et al. Clinical prognostic criterions of the dysplasia of the connective tissue // Rossiyskie meditsinskie vesti, 2009, vol. XIV, no 1, pp. 76–85 (in Russian).
3. Ivanova E.A., Plotnikova O.V., Glotov A.V. et al. Prevention of the health breakdown in adolescents with phenotypic signs of the dysplasia of the connective tissue // Kazanskiy meditsinskiy zhurnal, 2012, vol. 93, no 1. S. 93–97. (In Russian).
4. Rakhmatullina Z.A., Vykhristyuk O.F., Rusakova V.D. Dysplasia of the connective tissue and multi-organ pathology in children // Meditsinskaya pomoshch’, 2008, vol 5, pp. 29–31 (in Russian).
5. Genova O.A. Incidence and some clinical pathogenetic aspects of the undifferentiated dysplasia of the connective tissue in adolescents: avtoref. dis. … kand. med. nauk. Khabarovsk, 2011. 24 p. (in Russian).
6. Arsent’ev V.G. Dysplasia of the connective tissue in pediatric patients: etiology, classification, clinical picture, diagnosis criterions, treatment principles // Detskaya meditsina Severo-Zapada, 2011, no 3, pp. 43–52 (in Russian).
7. Sidorov G.A., Vinogradov A.F., Kornyusho E.M. i dr. Development of the dispensary observation of the pediatric patients with various degrees of the dysplasia of the connective tissue // Vestnik novykh meditsinskikh tekhnologiy, 2010, no 4, pp. 136–139 (in Russian).
8. Arsent’ev V.G., Aseev M.V., Baranov V.S. i dr. Investigation of the mineral density of the bony tissue in pediatric patients and in adolescents with dysplasia of the connective tissue // Pediatriya, 2010, no 5, pp. 73–76 (in Russian).
9. Kadurina T.I., Gorbunova V.N. Dysplasia of the connective tissue: guideline for the physicians. Sankt-Peterburg, 2009. 704 p. (in Russian).
10. Lapkin Yu.A. Hypermobility of the joints in the pediatric orthopedic practice // Kadurina T.I., Gorbunova V.N. Dysplasia of the connective tissue. SPb.: Elbi-SPb., 2009. Ch. II, Gl. 1. pp. 301–317 (in Russian).
11. Milkovska-Dimitrova T. Congenital failure of the connective tissue in children. Sofiya, 1987. 89 p. (in Bulgarian).
12. Appreciation of the main anthropometric data of the sexual development and arterial pressure in pediatric patients: guidelines / pod red. N.M. Vorontsova. L., 1984. 43 p. (in Russian).
13. Belozerov Yu.M., Osmanov I.M., Magomedova Sh.M. Diagnosis and classification of the mitral valve prolapse in children and adolescents // Kardiologiya, 2011, vol. 3, pp. 63–67 (in Russian).
14. Kretova I.G., Rusakova N.V., Berezin I.I. i dr. Health status of the students of the various types educational institutions in Samara // Pediatriya, 2011, no 1, pp. 125– 129 (in Russian).
15. Fedotova T.K. About specificity of the somatic status formation in children aged from 7 to 16 years // Pediatriya, 2005, no 5, pp. 92–94 (in Russian).
16. Jansson A., Saartok T., Werner S. et al. General joint laxity in 1845 Swedish schoolchildren of different ages: ageand gender-specific distributions // Acta Paediatr. 2004. V. 93. pp. 1202–1206.
17. Adib N., Davies K., Grahame R. et al. Joint hypermobility syndrome in childhood. A not so benign disorder? // Rheumatol. 2005. V. 44. P. 744–750.
18. Shabalov N.P., Arsen’ev V.G. Hereditary diseases of the connective tissue // Pediatriya: natsional’noe rukovodstvo: v 2-kh tomakh. M.: GEOTAR Media, 2009. T. 1. pp. 298–320. (in Russian)
19. Smits-Engelsman B., Klerks M., Kirby A. Beighton score: a valid measure for generalized hyper mobility in children // J. Pediatr. 2011. V. 158, № 1. P. 119–123.
20. Spivak E.M., Komrakova S.A. Mineral bone density and characteristics of its metabolism in undifferentiated dysplasia of the connective tissue syndrome in children // Vestnik Ivanovskoy meditsinskoy akademii, 2010, vol. 15, no 1. pp. 36–38 (in Russian).
21. Bravo J.F., Wolff C. Clinical Study of Hereditary Disoders of Connective Tissues in a Chilean Population. Joint Hipermobility Syndrome and Vascular Ehlers-Danlos Syndrome // Arthritis & Rheumatism. 2006. V. 54, № 2. P. 515–523.
22. Kalaeva G.Yu., Khokhlova O.I. Undifferentiated dysplasia of the connective tissue in adolescents // Rossiyskiy vestnik perinatologii i pediatrii, 2014, vol. 59, no 5, pp. 52– 58 (in Russian).
Review
For citations:
Kalaeva G.Y., Khokhlova O.I., Deev I.A. SCREENING METHOD OF THE DYSPLASIA OF THE CONNECTIVE TISSUE IN ADOLESCENTS. Bulletin of Siberian Medicine. 2016;15(2):35-44. (In Russ.) https://doi.org/10.20538/1682-0363-2016-2-35-44
Views:
2054
Email this article 