Sensitization to food allergies in the context of atopic comorbidity
P. Yu. Isaev,
O. I. Urazova,
V. V. Klimov,
M. I. Musina,
D. S. Zagreshenko,
A. A. Denisov,
Ya. V. Kukharev,
A. N. Shkatova,
A. V. Klimov https://doi.org/10.20538/1682-0363-2025-2-153-161
Abstract
The lecture considers a place of food allergy in the profile of allergic and, in particular, atopic diseases and its features, distinguishing this pathology from all other allergies. Three classes of food allergens are characterized, and sensitization to them involving cells and regulatory molecules, such as neurotransmitters, neuropeptides, cytokines, and others mediators, is described in detail.
At the current level of science, the mechanisms of oral tolerance and the causes of its breakdown are considered, resulting in clinical manifestations of food allergies, characterized by high polymorphism and complexity of diagnosis. Not only is a high rate of comorbidity of food allergies emphasized, but also its exceptional risks are pinpointed in terms of the development of anaphylactic shock, which is a difficult issue to explain in nutrition and digestion. The final part of the lecture is devoted to current and future therapeutic interventions in this pathology.
About the Authors
P. Yu. Isaev
Kanevskaya Central Hospital
Russian Federation
Competing Interests:
Russian Federation
108 Bolnichnaya St., Kanevskaya Village, 353780 Krasnodar Region, Russian Federation
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
O. I. Urazova
Siberian State Medical University
Russian Federation
Competing Interests:
Russian Federation
2 Moscovsky trakt, 634050 Tomsk, Russian Federation
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
V. V. Klimov
Siberian State Medical University
Russian Federation
Competing Interests:
Russian Federation
2 Moscovsky trakt, 634050 Tomsk, Russian Federation
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
M. I. Musina
Student Polyclinic
Russian Federation
Competing Interests:
Russian Federation
74 Kievskaya St., 634041 Tomsk, Russian Federation
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
D. S. Zagreshenko
Russian Medical Academy for Continuing Postgraduate Education, Novokuznetsk branch
Russian Federation
Competing Interests:
Russian Federation
5 Stroiteley Аve., 654005 Novokuznetsk, Russian Federation
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
A. A. Denisov
Siberian State Medical University
Russian Federation
Competing Interests:
Russian Federation
2 Moscovsky trakt, 634050 Tomsk, Russian Federation
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
Ya. V. Kukharev
Siberian State Medical University
Russian Federation
Competing Interests:
Russian Federation
2 Moscovsky trakt, 634050 Tomsk, Russian Federation
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
A. N. Shkatova
Student Polyclinic
Russian Federation
Competing Interests:
Russian Federation
74 Kievskaya St., 634041 Tomsk, Russian Federation
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
A. V. Klimov
Siberian State Medical University
Russian Federation
Competing Interests:
Russian Federation
2 Moscovsky trakt, 634050 Tomsk, Russian Federation
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
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Isaev P.Yu., Urazova O.I., Klimov V.V., Musina M.I., Zagreshenko D.S., Denisov A.A., Kukharev Ya.V., Shkatova A.N., Klimov A.V. Sensitization to food allergies in the context of atopic comorbidity. Bulletin of Siberian Medicine. 2025;24(2):153-161. (In Russ.) https://doi.org/10.20538/1682-0363-2025-2-153-161
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