Potential of PSMA-targeted imaging of tumors with various localizations

Diagnosis and therapy of malignant neoplasms are increasingly focused on the use of molecular targets involved in the multistage process of tumor pathogenesis. Prostate-specific membrane antigen (PSMA) is currently one of such molecular markers for prostate cancer, and over the past two decades, there have been active developments in PSMA-directed theranostics for prostate cancer therapy. However, numerous studies in recent years have shown that PSMA, despite its name, is not a specific molecular marker only for prostate cancer screening. It was revealed that the expression of this receptor in other neoplasms is associated with neovascular endothelium, which was the prerequisite for the beginning of studies on the clinical application of PSMA-directed visualization of tumors with various localizations.

This lecture analyzes the possibilities of using PSMA-targeted radionuclide diagnosis for various histologic types of tumors, as well as the features of PSMA expression in some tumors. The authors of the lecture demonstrate existing clinical examples of the results of diagnostic studies and the use of targeted radionuclide therapy. The lecture presents possible applications of PSMA-targeted visualization methods for obtaining additional information about the features of the tumor process.

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