Нейротрофический фактор мозга: значение в физиологии и патологии сердечно-сосудистой системы

В лекции проведен анализ литературных данных о роли нейротрофического фактора мозга (BDNF) в развитии и функционировании сердечно-сосудистой системы и его участии в патогенезе сердца и сосудов. Информация структурирована в соответствии с многофункциональными свойствами и эффектами BDNF, позволяющими рассматривать нейротрофический фактор мозга в качестве терапевтической мишени для ослабления миокардиальной дисфункции и восстановления деятельности сердца при ишемии/реперфузии.

Приведены данные о способности нейрокина оказывать кардиопротекторное действие посредством активации ангиогенеза и неоваскуляризации ишемизированной ткани миокарда путем повышения жизнеспособности эндотелиоцитов. Известно, что вегетативный тонус является важнейшим показателем состояния сердечно-сосудистой системы. Вопрос о характере влияния нейротрофического фактора мозга на активность симпатических и парасимпатических нейронов остается открытым. Однако в настоящее время преобладает мнение о том, что BDNF регулирует частоту сердечных сокращений, усиливая парасимпатическую активность стволовых структур головного мозга. На основании экспериментальных и клинических сведений рассматриваются перспективы применения аналогов нейрокина в кардиологической практике.

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