Modern aspects of separate mechanisms of sepsis pathogenesis
https://doi.org/10.20538/1682-0363-2026-2-161-172
Abstract
The objective of the review is to analyze the continuously developing and changing ideas about the numerous interrelated mechanisms of sepsis pathogenesis, new research directions and potential approaches to treatment that are formed on their basis. A search was conducted using keywords in the PubMed database of relevant scientific publications for the period after the Third International Consensus Definition of Sepsis and Septic Shock (Sepsis-3).
The review considers modern concepts of the main pathophysiological mechanisms of sepsis development, which remains a pressing health problem. The data accumulated to date on various pathophysiological mechanisms of sepsis reflect the complexity of its pathogenesis, caused by the development and coexistence of a large number of diverse pathological reactions with wide overlap and interaction of various signaling cellular pathways responsible for both cell survival and death. In this case, the outcome of the process is determined by the delicate balance of developing reactions, in particular the balance between activation of the immune response and immunosuppression. New research directions into the pathogenesis of sepsis focus not only on the mechanisms of modulation of the immune system activity, but also on the study of a wide range of pathophysiological processes associated with the development of multiple organ failure syndrome. Accordingly, there is a search for new therapeutic strategies, and with the recognition of sepsis as a heterogeneous syndrome, a transition to more personalized approaches in its treatment.
About the Authors
L. A. Naumova
Surgut State University
Russian Federation
Russian Federation
1 Lenin St., 628412 Surgut, Russian Federation
M. B. Yallyev
Surgut State University
Russian Federation
Russian Federation
1 Lenin St., 628412 Surgut, Russian Federation
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Naumova L.A., Yallyev M.B. Modern aspects of separate mechanisms of sepsis pathogenesis. Bulletin of Siberian Medicine. 2026;25(2):161-172. https://doi.org/10.20538/1682-0363-2026-2-161-172
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