Association of Thr12Ser polymorphism in mitochondrial transcription factor A TFAM gene with coronary artery disease
https://doi.org/10.20538/1682-0363-2012-6-47-50
Abstract
In this study we genotyped polymorphism Thr12Ser (rs1937) in TFAM gene in two groups: patients with coronary artery disease and control group (people from Tomsk population). For genotyping was used restriction fragment length polymorphism. We have found significant higher genotype CC frequency in men with coronary artery disease — 4.52% compared with control men — 0.45% (χ2 = 6.315; р = 0.043; OR = 10.45). Thus genotype CC is associated with coronary artery disease in men fromTomsk population.
About the Authors
T. V. Zheikova
НИИ медицинской генетики СО РАМН, г. Томск
Russian Federation
Russian Federation
M. V. Golubenko
НИИ медицинской генетики СО РАМН, г. Томск
S. V. Buikin
НИИ медицинской генетики СО РАМН, г. Томск
O. A. Makeeva
НИИ медицинской генетики СО РАМН, г. Томск
A. A. Lezhnev
НИИ кардиологии СО РАМН, г. Томск
I. V. Tsimbalyuk
Сибирский государственный медицинский университет, г. Томск
V. M. Shipulin
НИИ кардиологии СО РАМН, г. Томск
V. P. Puzyryov
НИИ медицинской генетики СО РАМН, г. Томск
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Review
For citations:
Zheikova T.V., Golubenko M.V., Buikin S.V., Makeeva O.A., Lezhnev A.A., Tsimbalyuk I.V., Shipulin V.M., Puzyryov V.P. Association of Thr12Ser polymorphism in mitochondrial transcription factor A TFAM gene with coronary artery disease. Bulletin of Siberian Medicine. 2012;11(6):47-50. (In Russ.) https://doi.org/10.20538/1682-0363-2012-6-47-50
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