The activity of extracts from Saussurea controversa DC and Filipendula ulmaria (L.) Maxim studied on experimental osteomyelitis by means of 3-phase scintigraphy. The use of aqueous-ethanolic extracts of the aerial parts of plants helps to reduce the fixation of the radiopharmaceutical in the affected area and what characterizes their positive impact on the disease. These plants are promising objects for study of medicines the treatment of osteomyelitis.

Purpose of the research was studying circannual variation of parameters of hormonal regulation, lipids, oxidative systems of an organism of healthy men and women in conditions of Western Siberia.
Monthly, within five years (2005–2009) on conditions of the voluntary informed consent 580 healthy donors (370 men and 210 women) in the age of from 25 up to 47 have been surveyed. In blood serum defined concentration of cortisol, insulin, thyroid hormones, concentration of cholesterol and other lipids, markers of stress and oxidative. Obtained data have been processed by adequate methods of the mathematical and statistical analysis.
The analysis of results has shown that activity of functioning systems adaptation an of organism at all levels of the organization undergoes essential changes within a year. Revealed correlations are the certificate of cause and effect attitudes between the systems, providing adaptive mechanisms in constantly changing conditions of a living environment. The received results testify to an absolute must of revision of diagnostic criteria and expansions of concept of norm in view of circannual variation of functioning of physiological systems of an organism.

Blood-red hawthorn (Crataegi fructus) are a popular cardiotonic herbal materials, which widely used in medical practice in our country and abroad. In order to prevent diseases of the cardiovascular system is appropriate to prescribe herbal medicines, because they combine the breadth and softness of therapeutic action, along with the absence of a significant number of side effects and contraindications.
The purpose was to study diuretic and antidepressant activity of thick fruit extract of blood-red hawthorn.
Material and methods. Under laboratory conditions we obtained a thick extract of blood-red hawthorn fruits. This phytopharmaceutical was studied by us for any diuretic and antidepressant activity. Investiga- tions were carried out on white rats of both sexes weighing 200–220 g. Each experimental group consist- ed of ten animals. Study drug was administered intragastrically by stomach tube. Control in both cases served as purified water. For determination of diuretic activity, we used a thick extract of hawthorn fruits in a dose of 20 mg/kg against the background of the water load in the amount of 3% of body weight of the animal. Reference preparation was chosen dichlorthiazid 20 mg/kg. It was administered once. After ad- ministration the animals were placed in metabolic cages for urine collection for 24 hours. The study de- termined diuresis, natriuresis, kaliuresis, and kreatininuresis for 4 h and 24 h of the experiment. On the day of the experiment the animals of the control group was administered water load of 3%, and experi- enced – intragastrically drug in an identical amount. Animals were placed in a metabolic cage for a day. Collected 4 h and 24-h urine sample. Determined by renal excretion of water was recorded concentration of sodium and potassium by flame photometry in the fiery liquid analyzer PAG-1, creatinine – colorimet- ric method for photocolorimeter CFC-3. For determining antidepressant activity we used a thick hawthorn extract in a dose of 25 mg/kg of animal body weight. As a synthetic drug comparisons, we used amitriptilin 5 mg/g.
Results. It was found that the thick extract of fruits of blood red hawthorn in a dose of 20 mg/kg for 24 hours increases the diuresis experiment, both by increasing the glomerular filtration rate and by lowering tubular reabsorption. For thick extract of fruits of hawthorn blood-red characteristic expression antide- pressant activity.
Conclusion. The studied preparation of blood-red hawthorn’s fruits have properties to provide complex nephrotropic and neurotropic activity on the living organism.

From 1989 to 2013, demographic processes in the Republic of Buryatia were analyzed. Changes in the basic parameters of the population movement: births, deaths and migration were influenced by the sex and age structure of the population. The proportion of the Russians decreased from 69.9% in 1989 to 64.9% in 2010 and the number of the Buryats increased from 24.0 to 29.5%. With the increase in the proportion of residents over 60 years, a process of the aging of the population was observed. In 2000–2013, there was a positive dynamics of the natural movement of the population, the natural increase in /Т ёь9013 was 5,8 per 1000 persons. Migration population decline in the Republic of Buryatia keeps stable.

Prognosis of disease outcome is important procedure for cancer patients treatment. The article presents the problem of elicitation of breast cancer prognosis criteria from immunological data as parameters complex.
The aim is to identify necessary and sufficient amount of immunological parameters for accurate classification of breast cancer patients with various outcomes – clinical remission and hematogenous metastases.
Material and methods. 36 immunological parameters were studied in 197 breast cancer patients T1–4N0–3M0. The “next neighbor” algorithm was used for identification of informative parameters. Detection of informative parameters complex was carried out by using ADD and DEL methods.
Results. Two sets of informative immunological parameters were detected. The ADD method elicited parameters related to T-cell immunity, DEL – to humoral response.
Conclusions. The complex of 17–19 immunological parameters characterizing different elements of immune system is necessary for accurate classification of breast cancer patients with different outcomes (presence/absence of hematogenous metastases).

The relevance of studying the role of matrix metalloproteinases (MMP) and tissue inhibitors (TIMP) in the pathology of the urinary system is determined, by the significant prevalence, prone to recurrent course of kidney disease in children. It is known that MMP-1 has pro-inflammatory action, MMP-2 and MMP-9 inhibits inflammation. TIMP-1 and TIMP-2 restricted cleavage of collagen. Disbalance between MMP and TIMP accompanied by the accumulation of extracellular matrix, increases the risk of chronic renal failure.
The purpose of the study – to assess the role of MMP and TIMP involved in the processes of inflammation and resulting to renal dysfunction in glomerulonephritis and pyelonephritis in children.
Material and methods. Surveyed of 15 children with a diagnosis of acute glomerulonephritis, 25 – chronic glomerulonephritis, 40 – chronic obstructive secondary pyelonephritis and 20 healthy children. In the group of patients with chronic glomerulonephritis renal function was impaired in 10 patients with chronic pyelonephritis – in 20 patients. The content of MMP-1, -2, -9 and TIMP-1, TIMP-2 in the serum of children was determined by ELISA.
Results. It was found that in acute and chronic glomerulonephritis in children increases the content of MMP-1, MMP-2 is almost not changed, while the content of MMP-9 is reduced, which characterizes the presence of inflammation. In chronic pyelonephritis in a more pronounced reduction of MMP-9, antiinflammatory. The most significant changes were found in patients with impaired renal function. In all groups of patients experienced an increase in the level of TIMP-1 and TIMP-2.
Conclusion. Thus, increasing the level of tissue inhibitors, elevated levels of MMP-1, decreased MMP-9, contributes to the progression of the disease and the development of inflammation and the accumulation of extracellular matrix proteins of interstitial kidney tissue, resulting in sclerotic and fibrotic changes.

The relevance of the presented paper deals with the necessity of determining problems and effective solutions for medical organizations on the stage of medical documentation reports control purposely for forecasting the average of financial resources that can be obtained in the scope of compulsory health insurance program.
The aim of the study – for the purpose of further issues definition present formal model of the analyzed process using a set of system analysis methods.
Material and methods. System analysis methods, especially IDEF0 diagrams and activity diagrams, for estimation of medical expert’s agreement Cohen’s kappa was used.
The results. Based on the specification documents and expert’s experience the spread description on the process the control of volume, duration, quality and conditions of medical service assignment by medical organizations conducted by medical insurance organization was presented. Inputs, outputs, elements of management and executives were determined. As a result of decomposition, subprocesess were presented within activity diagrams.
Conclusions. The obtained results of research allows to conclude that there is a set of problems which appear when medical organizations send reports for getting financial resources for clinical service realization in the scope of compulsory health insurance program. On the grounds of determined problems, we can conclude that it is necessary to develop an intellectual information system for estimating clinical records concerning getting financial resources for clinical service. In respect that human factor influence on the main stages of the analyzed process, we propose to use fuzzy logic as an inference engine. The self-learning function of the system will provide case-based reasoning.

Article is attempt of the critical analysis of modern approaches to treatment of a small intestine bacterial overgrowth syndrome (SIBO). SIBO now is one of the major problems in gastroenterology. At the same time, the bacterial overgrowth is cause and consequence of many diseases of digestive system and extradigestive manifestations. Many researches testify to prevalence of SIBO in patients with digestive diseases. However, pathogenesis of a disease is studied insufficiently today. Nevertheless, the available data of scientific researches allow to belong to the offered ways of diagnostics and treatment critically.
Data on physiology of microbiota of the digestive tract of the healthy person are provided in a review. Mechanisms of antimicrobic resistance of a microbiota of intestines are considered. Interrelations between an antibiotikassociated degeneration of normal flora and bacterial overgrowth are presented. The analysis of an antibiotiktherapi of SIBO indicates low efficiency and also possible ways became chronicle diseaseand frequent recurrence of an illness. The multiple-factors and complexity of pathogenesis of SIBO are leaded authors to a conclusion to use ethiopathogenesis approaches for solution of SIBO.

Health care is based on patient data. The doctor, nurse or medical assistant are able by education, training, knowledge and experience to interpret patient data needed for diagnosis and treatment. Health care is dependent on a good education with respect to the management of data, information and knowledge. International activities point to ways to achieve a good level of education. These include criteria for curriculum development and accreditation, quality of information systems, further experience with a comprehensive training concept in England and the 10X10 approach in the United States.

In the article a small amount of information about medical control in a country and Western Siberia in 1920th are presented. The participation of V.S. Pirusskiy in this organization is described. Basic directions of medical control are explained. The information on medical workers’ participation in the activity of committees of physical culture and organization of physical education is given.