The purpose of the present research lies in objectivism estimation of life quality at the patients with malignant brain glioma in dynamics of their complex treatment. Patient's life quality was estimated both on Karnovsky scale and computer stabilometry, which was investigated before each course of chemotherapy. Computer stabilometry possesses of high sensitivity for registration of statokinetic infringements and allows estimating evenly the life quality of neurooncologic patients along with its subjective registration on Karnovsky scale.

To analyze patients with hypertensive encephalopathy (HE) in the course of antihypertensive therapy (AT) clinical psychological and neurological characteristics in dynamics of 6 months after the first screening were estimated. 107 patients with HE of I—III stages and 30 controls matched for age and sex were examined. The clinical, ultrasonic diagnostics and quality of life (QL) index were applied. In the process of HE development and progression decreases of the physical and psychological constituents of health were shown, pain barrier was decreased. The QL analysis shown that in the process of AT in dynamics the physical and psychological constituents of health increase.

For the diagnosis and prognosis of various diseases is essential to determine specific markers in blood serum. Neuronspecific enolase (NSE) is a common marker of differentiatedneurons. The aim of the study was to evaluate the activity of NSE in patients with Parkinson's disease (PD) and chronic cerebral ischemia. The study results showed that the activity of NSE varied dependingon sex and age in PD patients, the stage and rate of progression of disease, age debut and severity of cognitive impairment. Thus, determination of NSE in the serum of PD patients should be included in the complex examination of patients with PD, as an additional marker of the neurodegenerative process.

A frequency of secondary hypogonadism after surgical treatment of patients with tumors of the chiasmosellar aria was defined. 30 patients were examined. A secondary hypogonadism was revealed in 70% of cases. The average levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) both in male in female were lowered or were on the low bound of the norm. This phenomenon denotes to the secondary nature of the hypogonadism. Most often secondary hypogonadism developed in patients operated apropos of the craniopharyngeoma and prolactinoma.

The perinatal hypoxia (PH) in preterm newborns is associated with elevated levels of matrix metalloproteinase 9 (MMP-9), superoxide dismutase (SOD) and thiobarbituric acid reactive substances in umbilical cord blood plasma. The severity of PH Apgar scores correlated with SOD (r = –0,40; p = 0,006) and MMP-9 (r = 0,36; p = 0,023). It is assumed that the SOD increase prevents the reactive oxygen species mediated activation of MMP-9, which destroy the collagen of the basement membrane of the bloodbrain barrier.

We studied the epoophoron in women with benign ovarian tumor using morphological methods. It was established that the structure epoophoron in women with benign ovarian tumors, there are significant differences compared with controls. This manifests itself in reducing the number of tubules, increase in their specific area, outer and inner diameter, the height of the epithelium, the presence of secretions in the lumen.

Investigation aim is to expose sex features of interdependence between erythrocytes homeostasis indices and heart remodeling in essential hypertension (EH) and hypertensive encephalopathy (HE) patients. 168 patients (110 men) with EH 2th staid, 2th degree and HE 1—2th staid were enrolled. It was executed blood test, echocardiography by standard method. In men erythrocytes homeostasis indices correlated with structural and functional alterations. In women erythrocytes homeostasis indices correlated with diastolic function. There were exposed sex-specific interdependence between erythrocytes homeostasis indices and heart remodeling.

In Altai Region, Russian Federation, multiple sclerosis (MS) prevalence is found in 39,9 cases of 100000 with wide variation in certain areas of the territory and ethnic corridor widening. Genotypes HLA-DRBI (13/15, 15/15, 15/3, 3/other) are associated with MS risk factors; recent illnesses (before 15 years old), such as chickenpox, rubella, herpes, chronic tonsillitis, and also head trauma before the illness debut are not associated with MS hazard.

Results of complex research of features of clinical and immunological profiles tick-borne encephalitis during the sharp period in Tomsk Region are resulted in the article. Last years redistribution of a parity of clinical displays of the sharp period in favor of prevalence of feverish forms of disease and a tendency to increase in cases of long circulation of an antigene of a virus tick-borne encephalitis is marked. One of the important reasons of such effect is decrease in immunological reactance of an organism with development of cytokine’s disbalance and expression infringement receptors of cytokines with lymphocytic cages.

To study influence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features of multiple sclerosis (MS) subject to sex belonging in Omsk city and Omsk region. Methods: neurological examination, molecular-genetic, statistic analyses. 265 patients with multiple sclerosis and 576 healthy controls was observed. Results: observable polymorphic loci don’t associated with sex. In group of men dysfunction of the pyramidal, visual, pelvic functions on course of MS, in women group — dysfunction of the pyramidal functions, duration of the disease, height, CD40 genotipe.

To assess the life quality in patients with hereditary neuropathy Charcot—Marie—Tooth in the Krasnoyarsk Region. Life quality was assessed in 28 patients with confirmed diagnosis of hereditary neuropathy Charcot—Marie—Tooth, using the «EuroQuality of Life — 5 Dimention», Rankin scale. A significant decline in the quality of life in patients with hereditary neuropathy Charcot—Marie—Tooth suggests the need to develop strategies for their physical, medical and social rehabilitation.

1168 cases of acute stroke were investigated with the method of Hospital Stroke Register. Computer-based tomography was performed in 93,9% cases, autopsy — in 2,4% cases. Ischemic stroke prevailed in all the age groups. Mortality rate was 25,5%, 24% stroke patients are needed in help.

This article describes the clinical case of brainstem encephalitis and criteria correspond to the clinical criteria for Bickerstaff encephalitis.In domestic literature, we not found descriptions of this pathology and decided to describe their own clinical case.

To improve the results of surgical treatment the patients with discogenic compressive syndromes. Using the denervation of interbody discs and facet joints in series allow us, first off all, to induce, and then to discontinue the reflex-pain syndrome in 41 patients in preoperational period, and in 39 patients in long-term postoperative period. Good results come to 82,8 и 89,8% (р < 0,05) accordingly.

Magnetic resonance imaging (MRI) was used for diagnosis of thoracic disc herniations and for management strategy determination. 24 symptomatic patients underwent MRI using sagittal T1 and T2-weighted spine echo and axial multiplanar gradient refocused images. Disc herniations were classified according to their size, location in the spinal canal and to the extent of cord compromise. MRI data correlated with the neurological status in all cases and assisted in the management strategy determination. 10 (41,7%) patients with small disc herniations and compression of subarachnoid space demonstrated pseudoradicular syndrome and were managed conservatively. 14 (58,3%) patients with medium or large disc herniations and compression of the cord demonstrated myelopathy or radicularpathy syndrome and were managed surgically. Our results show that MRI is a useful diagnostic tool for diagnosis, management strategy determination and assessment of treatment results.

Bladder tuberculosis is one of the most serious complication of nephrotuberculosis. Efficiency of current therapy is 42.1% only; it was a reason for creation of new scheme of etiopathogenetic therapy and surgical treatment. 63 patients were enrolled in study: 1st group received standard therapy and 2nd — modified. 9 patients from control group were operated with creation of neobladder. Results of therapy for patients treated with levofloxacin and trospium chloride were twice higher than after standard.

Pathological processes in the thyroid and the cervical spine through the structures of the autonomic nervous system may provide each other mutual influence. Detection of additional pathogenetic factors in uzloobrazovaniya help develop additional methods of treatment and prevention tireopaty.

To study efficacy and safety of prolonged course of cerebrolysin therapy in vascular dementia, 48 patients, aged from 59—77 years, with mild and moderate dementia have been studied. A potential of 3-years course of cerebrolysin therapy to slow down the progression of cognitive impairment in patients with vascular dementia has been studied in the open study. Efficacy and safety of cerebrolysin were assessed clinically and with a battery of widespread scales and neuropsychological tests. The improvement of cognitive, functional and motor activities in patients with mild and moderate dementia indicate the high effectiveness of cerebrolysin. A prolonged therapy allows to prevent the progression of cognitive impairment and development of vascular dementia.

In the article presented results on research of dynamics of impellent and emotional infringements, qualities of life of poststroke patients in the regenerative period against the spent physical rehabilitation including methods of mirror therapy and proprioceptive correction. By surviving of 39 patients was shown the efficiency of rehabilitation actions on key parameters of impellent activity and self-service degree. During the regenerative period was revealed increase of frequency, but reduction of expressiveness of disturbing-depressive infringements, life improvement of quality poststroke patients.

A unified simulation language has been used to develop the structurally functional model of the territorially distributed information system for follow-up care and monitoring of the health status of children with neurological disorders living in remote areas of the Tomsk Region. With this model and structured programming methods, client-server technologies along with the structured query language allow the development of the on-line information-analytical system, which uses the common information space and accumulates data on children with neurological disorders.

The present research aimed at studying association between Apo E polymorphism and certain types of stroke and also association factors of lipid profile’s results and different types of stroke it depends on sex and conditions of living in typical West Siberian megapolis (Novosibirsk).

The causes of brain stroke were registered in representative population with population about 150 000 in according to standarts of WHO program MONICA and previous program «Register of stroke». From 2003 to 2007 among new registered and repeated causes of stroke was form at random 15% sample (261 patients). The average age of stroke attack is 61,3 ± 1,0 for men and 61,3 ± 1,0 for women.

Independent influence of APOE gene's genotypes polymorphism on development at different stroke patients has not been revealed.

The study cerebral rhythm reactivity by functional load at 49 patient’s with epilepsy de novo. Make photic stimulation and cognitive activation. It was demonstrated that patients, who get remission on starting anticonvulsant therapy have intact brain reactivity.

This work is devoted to identifying the relationship between disorders of emotional personal sphere of persons with temporal lobe epilepsy and their preferred coping strategies. The objects of the study were 40 people, including 20 patients with verified diagnosis of temporal lobe epilepsy who are treated at the neurological clinic of the Siberian State University. Clinical and psychological method of research included: the study of neurological status, multivariate Personality Inventory FPI, a scale assessing the level of situational anxiety, C. Spielberger and Y. Khanin, research methods coping strategies A. Lazarus. The results obtained in the present study results confirm the need for early detection of affective spectrum disorders in patients with temporal lobe epilepsy. Because of their availability and high levels of lead to a change in methods of coping with stress, this in turn leads to restrictions in the social sphere.

The complex study of 63 patients was performed. It included 45 males and 18 females (the average age 31,5 ± ±13,3). All the patients had an acute stage of traumatic brain injury (TBI). The patients were divided into 3 groups. 27 patients had brain concussion, 12 and 24 patients suffered from mild and middle brain contusion. Emotional status study showed the increase of reactive anxiety. Life quality assessment showed a significant decrease in all of the questionnaire SF-36 scales. 15 brain contusion patients underwent neuroprotective therapy — they were given 10 intravenous injections of cerebrolysin within 10 days. All the patients showed less number of neurological symptoms, anxiety level and a significant quality of life improvement after the treatment. Thus, the acute stage of TBI is characterized by the quality of life and the adaptation capability decreasing. They are accompanied by the mild affective, emotional and autonomic impairment that demand neuroprotective treatment.

In practice it’s often observed the discrepancy between clinical presentation of cerebral lesions in neonates and results of instrumental studies (neurosonography and computer tomography). The aim of the research was to explore the possibilities of the method of EEG for diagnosis and prognosis of cerebral lesions in neonates. The study was carried out in the design of Longitudinal prospective cohort controlled comparative non-randomized study with a simple glare. The study results demonstrate a great diagnostic and prognostic value of the method of EEG in detecting cerebral ischemia in neonates.

On examination of 78 people with accurate amyotrophic lateral sclerosis the role of some risk factors in the development and the character of the flow of the disease was analyzed. The received findings don't allow excluding the participation of the viruses of herpes and cytomegalovirus in the emergence and development of amyotrophic lateral sclerosis. The most important is the observance of a hypocaloric diet, the prevalence of eating meat products, the availability of guidelines for the transfer of poliomyelitis, rheumatism, herpes infection, acute psycho-emotional stress for the 6 months before disease onset and some others.

The paper presents results of clinical and laboratory investigation of 106 patients with chronic brain ischemia (CBI) I—II stages, included detection levels of circulating desquamated endothelial cells, endothelin-1, autoantibodies to encephalitogenic protein, neuron-specific enolase and protein S100. Reliable changes of immune status as well as signs of endothelium dysfunction progressed with stage of CBI. Direct correlation between intensity of endothelium dysfunction and activity of neurodegererative process in brain was revealed.

The purpose of the study — to evaluate the effectiveness of the method tempo-rhythmic correction (TRC) distance in patients with Parkinson's disease (PD). We have used the device to determine step-speed performance rights, method TRC of walking, a questionnaire of quality of life of patients with PD (PDQ-39). Revealed that the method of TRC can improve walking in patients with Parkinson's disease, improve their life quality and reduce the pharmacoeconomic cost of treatment. Also, we have suggested a neuroprotective effect of the method of TRC.

The results of study, which devoted by diagnostics of neurodynamic speech disorders on the basis of clinical and computed speech transforming finding were shown. 186 patients in the poststroke period were examined. The possibility of using the method of computed transformation of time parameters of speech for objective registration of speech defeat and establishment of diagnosis of aphasia were revealed.

We studied importance the factors of risk for elongation of neck of uterus, incomplete and complete prolapsus of internal female genital organs. In distinguish groups reliable important: connective tissue dysplasia with pathological level of urine oxyproline, childbirth, traumatic childbirth, manipulations on the neck of uterus.

The results of the research covering a problem of application of medical standards in diagnostics and treatment of patients suffering dorsopathies are presented. Its results have shown laws between various approaches by efficiency to conducting patients, duration of hospitalization and duration of time loss of invalidity.

The purpose of this work is the study of efficacy of application of ultralow temperatures of liquid nitrogen in complex treatment of stomalgia.

440 patients with stomalgia were examined. Patients were given medical therapy, physiotherapy, psychotherapy and hirudotherapy as well as cryotherapy by means of the set of autonomus movable applicators made out of finely porous Nickelid Titanum (TiNi) with the use of liquid nitrogen. The estimation of the efficacy of the treatment was made according to the contents of adrenaline in saliva and by means of the estimation scale and questionnaires.