The lecture is addressed to clinicians who state for medical students the problems of genetic mechanisms of human diseases (medical pathogenetics). Epistemological and didactic aspects of interpretation of the «human genome» concept are considered, as well as Davidenkov—McKusick principles of clinical genetics, classification of hereditary human diseases, and problems of application of new genetic knowledge to medicine (translational medicine).

The article represents the main scientific school of the Chair of Internal Diseases Propedeutics of the Siberian State Medical University (Tomsk) in the form of the review of the Chair employees’ works published since 1963.

A investigation of the indices, characterizing a functional condition of the hemostasis in patients with peritonitis, to takes more reliable trend forecasting a development of the multiorgans insufficiency syndrome and unfavorable outcome of the disease, tran research of hemodynamic and autointoxication states.

Purpose of this research is to value impact of body loss weight-oriented psychotherapy on indices of depression and anxiety. We used weight, body mass index, CES-D depression scale and Spielberger—Hanin anxiety scale before and one month after body loss weight — oriented psychotherapy group of 30 overweight patients. We have found significant body loss weight and improvement of scales results during 1 month period.

The activity of cytokines and featuries of humoral immunity response in acute period of mixed infection of tick-borne encephalitis and Ixodidae borreliosis in children was researched. The delay of production of antibodies is revealed at meningoencephalitis form. The revealed changes of cytokines status can be used for an estimation of efficiency and correction of spent therapy.

In article the data, concerning features of cellular composition, proliferative activity and cytokines production of peripheral blood lymphocytes is presented in patients with various clinico-pathogenetic variants of pulmonary tuberculosis: drag-sensitive and drug-resistant infiltrative, disseminated, fibrous-cavernous. It is established that the extensive destructive tuberculosis without dependence from the clinical form of disease is accompanied by the expressed insufficiency of the cellular-mediated mechanisms of immunological resistance both to drag-sensitive, and to drug-resistant M. tuberculosis against quantitative prevalence of B-lymphocytes and intensity of their functional activity.

Alternatively spliced interleukins are very actively studied over the last years. Splice form of IL-4 — IL-4δ2 has antagonistic effects to its full form on proliferative activity of human mononuclear blood cells and their IL-6 production. Antagonistic effects between IL-4 and IL-4δ2 were confirmed and explained in this study due to combination of biochemical and computer methods.

The influence of the sum of water-soluble polysaccharides (WSPSs) extracted from sedge (Acorus calamus L.) rhizomes on the state of internal organs of rats and rabbits at a long parenteral administration has been studied. The intraperitoneal WSPS introduction to rats in doses of 20, 100, and 200 mg/kg of body mass for 3 months and the intravenous WSPS introduction to rabbits in doses of 25 and 50 mg/kg of body mass for 1 months caused no pathological changes in the morphology of internal organs and systems.

It was shown in experiments on rats, that dithizone induced zinc deficiency in prostate cells. Three phase type of fluctuations of cytochemically detected zinc concentration was observed in the cells: phase of primary decrease, phase of temporary partial restoration and the phase of secondary decrease. Sodium diethyldithiocarbamate unlike to dithizone didn’t induce damage of cells and secondary decrease zinc content in its.

Programmed cell death of tumor cells of line Jurkat in conditions of cultivation with various concentration of dexamethasone, selective inhibitors of Hsp90 (Heat shock protein — Hsp) (17-AAG) and Hsp27 (KRIBB3) was investigated. An estimation of realisation apoptosis spent by method of fluorescent microscopy with use annexin V-FITC and propidium iodide. Inhibition of Hsp90 and Hsp27 leads to activation of tumor cells Jurkat apoptotic program and strengthening of dexamethasone-induced apoptosis. Hsp27 and Hsр90 play an antiapoptotic role in tumor cells of line Jurkat.

Glucocorticoid supply of the organism of patients with laryngeal cancer at different stages of malignant process has been studied. Formation and development of laryngeal cancer is accompanied by hormone-metabolic disturbances of hypophysis-adrenalocortical system, their character and degree of development being determined to a large extent by the stage of malignant process.

The article includes the results of the researching vegetative provision of the cardio-vascular system activity of 314 sportsmen 9—25 years old in patience and while orthostatic testing. It was discovered that in different age periods the process of urgent the cardio-vascular system adaptation while orthostatic testing is connected with different controlling levels cardio rhythm activating.

Herpes-virus infection decrease of activity of villus Bcl-2 was increased in process of increase of a credit of antibodies to virus herpes. The increase of activity kaspasa-3 created action on DNK nucleus sincythiotrophoblast.

The association of the tumor necrosis TNF-α –308G/A polymorphism and interleukin-8 genetic IL8 –251А/Т polymorphism with the development of the chronic obstructive lung disease (COLD) in two Tomsk populations (Siberian Tatars and Russians) has been studied. The data on interethnic differences in the structure of COLD susceptibility have been obtained. In Siberian Tatars, the TNF –308G allelic variant plays a role in the COLD development. In Russians, no association of the studied genetic markers with COLD was reveled.

Ultrasound dopplerography can reveal minimal disfunctions of intrahepatic hemodynamics. Linear speed of hepatic artery and hepatic vein (peak S and D) rises in the presence of dynamic and to a greater extent organic (inflammatory) cholepathias. The increase of blood flow speed occurs when vessel radius expands. This phenomenon can be explained by dilation of intrahepatic vessels which is more defined when the matter concerns inflammatory cholepathias and less defined among dynamic ones. Indices of intrahepatic hemodynamics may serve as indirect signs of given diseases among children and may reveal pathology on the earliest stages of its development.

For finding-out of a role monomer and dimer srilbens in realization hepatoprotective properties of polyphenols maakia amurensis activity of polyphenolic complexes from wood (Maksar), an extract of cellular culture maakia amurensis, and also monomer and dimer srilbens, allocated of a substance Maksar was investigated.

Therapeutic efficiency of researched objects was estimated on their influence on survival rate of animals, morphological and biochemical parameters of a liver and wheys of blood of rats with an experimental СCl4-hepatites. It was established, that hepatoprotective influence of Maksar and an extract of cellular culture maakia amurensis is caused by presence of the sums isoflavonoids in their structure. Monomer and dimer srilbens do not show therapeutic activity at an experimental toxic hepatites.

The aim of our research was analysis and comparison of chronic obstructive lung disease clinicalsigns and function indices of external respiration apparatus and inspiratory-expiratory high resolution computed tomography. 48 patients with chronic obstructive lung disease were examined. The importance of respiration biomechanics and inspiratory-expiratory high resolution computed tomography indices for diagnostics of broncho-obstruction at an early stage with unchanged forced expiration volume within the first second was revealed.

The comparative evaluation of modern imaging methods gives evidence of great opportunities of both MRT and US in the detection of structural alterations of joints at psoriatic arthritis. The key role is assigned to ultrasonography which has proved to be highly sensitive in the disclosure of peripheral joint synovitis and allows the follow-up during the treatment course.

The aim of this study was to improve the results of treatment of patients with infected pancreatonecrosis complicated with phlegmon of retroperitoneal fat. Toward this end, the following tasks were formulated: to develop a new way of drainage of the retroperitoneal fat at infected pancreatonecrosis — retroperitoneostomy and to analyze comparatively the efficiency of traditional methods of drainage of the pancreatic gland zone at infected pancreatonecrosis (omnetobursotomy, lumbostomy) with retroperitoneostomy.

The analysis was based on the results of examination and treatment of 60 patients with pancreatonecrosis complicated with phlegmon of retroperitoneal fat, who were operated in surgical departments of the Tomsk municipal hospital no. 3 in 2004—2008.

The use of retroperitoneostomy in the treatment of infected pancreatonecrosis complicated with phlegmon of retroperitoneal fat decreased postsurgical complications from 36.6 to 15.79% and lethality from 56.1 to 21,0%.

Studied antioxidant and therapeutic efficacy of the product fermented mares milk — kumis in the complex sanatorium treatment of 134 patients with stable angina pectoris I, II functional class (FC). Made kumis derived from fermented mares milk, Lactobacterium bulgaricum and yeasts such as Torula.

Kumis contributed to the activation of antioxidant enzymes against inhibition of peroxidation processes of metabolism and lipid-lowering effect. The developed approach is an effective method of complex of regenerative therapy in patients with chronic coronary heart disease.

Respiratory distress syndrome of the newborn is a basic pathobiology immature infants and this grave condition of early neonatal period often is the cause of chronic lung disease — bronchopulmonary dysplasia (BPD). BPD is marked by hyperreactivity of bronchi. The growth of this pathobiology in view of survival of immature infant is increasing in recent years. To measure functional status of respiratory tracts of infants with classical methods (spirography) is impossible. But there is a new method of diagnostics of broncho-obstructive syndrome, it is broncho-phonography. This method is noninvasive and can be used without active patient’s part in investigation. The examination results of immature infants with respiratory distress syndrome and with bronchopulmonary dysplasia (BPD) with the help of broncho-phonography method are described in the article.

The results of respiratory patterns of immature infants are normal in spite of their disease. That’s why we can speak about usage of broncho-phonography method in differential diagnostics of wheezing and restrictive dysplasia.

For the purpose of optimization of medicine supply of the population and disease-prevention institutions in conditions of closed administrative-territorial regions (CATR), we have studied one of the optimization trends — the efficiency of retail network of CATR using dynamic lines indices. On the base of the conducted consumers’ segmentation by solvency criterion we have worked out the recommendations on the structure optimization of chemist’s network of CATR in Zelenogorsk.

The investigation of the state of health of Tomsk people subjected to the action of radiation during the liquidation of technogenic accidents and disasters has revealed the progressing worsening of the health. Some peculiarities of the morbidity, invalidization, and mortality have been noted. An important aspect of the health improvement is the development and realization of individual rehabilitation programs.

Peculiarities in the structure of mortality of people living in the Tomsk Region have been revealed, and main ways to decrease the mortality have been determined. In 2002 the death rate in the Tomsk Region was 14.3 per 1000 people, which is lower than the average Russian death rate (16.3). The analysis of death causes has shown that the most frequent causes are diseases of the blood system, while the second and third places are occupied by the death from neoplasm, as well as from accidents, poisoning, and traumas.

The health factor should become of the high priority in all spheres of human activity. Any measure should favor the formation of the healthy life style and everybody’s personal responsibility for the health. It is worth developing the interbranch demographic concept of the Tomsk Region as an integral part of the concept of the enhancement of life quality for people living in the Tomsk Region.

On the basis of the retrospective stratified research of 307 patients (143 men and 164 women) with the verified chronic gastritis, association with helicobacter pylori, lead on the basis of 6 municipal establishments of Omsk treatment of the given category of patients is established, that at equal efficiency of out-patient-polyclinic and stationary forms of rendering of medical aid by clinical criterion, from a position of budgeting, it is the most expedient in conditions of out-patient-polyclinic supervision.

Proposed organizational aspects of rehabilitative care for patients with traumatic disease of the spinal cord. Aim was to study the organization providing rehabilitation of spinal patients. Identified the following stages of rehabilitation services: a full-fledged conservative therapy, rehabilitation, improvement or compensation for lost functions, the restoration of household activity, the restoration of social activity. Properly set the organization of rehabilitation services, allows patients to our clinic undergo a complete rehabilitation, which greatly improved the results of treatment of this severe pathology.

The thorny and mystery full course of life the fine Russian surgeon, professor Vladimir Nikolaevich Derevenko, the course became the subject of historical discussion and different fictions sequel to attract attention of the investigators multitude. In important measure it connected with the close relations between the doctor and the last Russian emperor's family right up to fatal death on July of 1918. It necessary, to note the scantiness of authentic biographical facts, presented in accessible sources and literature. This publication competently extended the personal biographical state in the context of dramatic Russian history.

The creative biography of Professor S.M. Khlynin, prominent Siberian scientist and health care organizer, head of the department of health care organization and public health of the Siberian State Medical University is presented. Main fields of his scientific and public activity are concerned.