This article is dedicated to rationale of pharmacotherap y in the treatment of depressive disorders. Differentiation of allele gene variances, linked to metabolism of antidepressants, was conducted. Genetic status of patients and individual parameters of antidepressant’s metabolism took into account in every clinical case. Results of this research can allowed to forecast effectivene ss, compliance and tolerance of antidepressants.

Activity of cytokines of tick-borne infection of children was researched. Revealed low level of interferon-γ concentration testify about abnormality of cellular link immune protection and typical for focal forms of tick-borne encephalitis. Severe forms of disease run with background increase of interleukin-6 and interleukin10. Maximum increase of tumor necrosis factor-α was detected in cases of mixed-infections. Borreliosis infection flows with background domination of Th-2 over Th-1 type of immune response.

Study process apoptosis cells in relaption and remittion in 91 patients with multiple sclerosis. Study apoptosis cells in patients with multiple sclerosis. Absolut apoptosis cells in remittion high.

Risk of the stroke in population men in 25–64 years old with vital exhaustion in the course of 14 years was examined. WHO-MONICA-psychosocial program are using. Workers and low education men has risk of the stroke more often. Risk of the stroke in the 25–64 years old men population associated with vital exhaustion.

In liquor 30 multiple sclerosis patients with remittent kind of clinical course the concentration of cell-cell adhesion molecules (sPECAM-1, sVCAM-1) and tumor necrosis factor (TNF) α, not interleukin-1β, was higher during the period of exacerbation compared to the period of remission. These changes are supposed to display the activity of pathogenesis important processes multiple sclerosis in cerebral tissue of multiple sclerosis patients.

Eighty patients with arterial hypertension (AH), aged 52,4 years, were studied. A diagnosis of mild cognitive impairment (MCI) in 61 patients met traditional clinical approach, neuropsychological examination. Significant correlation between the level of cognitive dysfunction and blood concentration of NO, endothelin-1 and apoptosis markers in researching groups were found. The results obtained suggest that markers of endothelial dysfunction and apoptosis could prove to be the early predictors of cognitive impairment in patients with arterial hypertension.

An inspection is conducted 60 patients with hemispheric ischemic stroke in age from 51 to 69 years, part on the degree of expressed of neurological deficit in obedience to the Scandinavian scale (19,0 ± 1,9) – I group (27), (41,1 ± 3,5) is II a group (33). The comparative analysis of neurological deficit is given, level neuron-specific enolase (NSE) in blood, hemodynamic indexes, character of atherosclerotic name-plates, exposed on the basis of ultrasonic duplex research of main arteries of cerebrum in a dynamics. Dependence is exposed between expressed of neurological defect, degree of damage of fabric of brain, characterized by the change of level of NSE and degree of disturbances of hemodynamic. Clear dependence is marked between a neurological defect and decline (p < 0,05) of high systole speed in a poststenotic area. Character of atherosclerotic name-plates reflected pathogenic of ischemic stroke.

Studies of surgical outcomes in multifocal epilepsy patients showed them to depend on epileptic foci sites in two groups of the diseased according to J. Engel scale (1993): 92 early postoperative period patients (group 1), and 30 late one patients (group 2). Of 92 group 1 patients unilateral cortical epileptic foci were diagnosed in 62 (51.7%), bitemporal ones in 30 (20.0%) patients. Of 30 group 2 patients – unilateral cortical in 17 (42.5%), and bitemporal in 13 (32.5%) patients. In group 1 remission of the seizures and decrease of their frequency over 80.0% was achieved in 80.4% of the patients, in group 2 – decrease of seizure frequency over 50.0% in 67.7%, and recurrent seizures in 26.7% of the patients.

The neurophysiological (the registration of induced potentials P300) and the psychological examinations of 70 patients, males, with chronic mercury intoxications (ChMI) and discirculatory encephalopathy (DE) have been performed with aim to reveal the features of cognitive disorders (CD). The study results have shown the presence of light CD and small demention in the patients of both groups, preferably, of subcork type for the patients with ChMI and preferably of cork type – for the patients with DE.

Adopted neuro-psychological observation of 69 children with hypermetropia. There were also (cross-eye) squint in 35 cases. It is established there are reliable deflections in higher psychological functions for children with vision malfunctions. The main lesion localization is determined in left hemicerebrum 63.3% and in right hemicerebrum 45.5%. In children with hypermtropia squint (cross-eye) doesn’t have influence to severity order of brain structures formation abnormality.

The operative, long-term memory (Mendelevich V.D. technique, 1999) and attention (proof assay of Burdon) at 96 convalescents with the meningeal form tick-borne encephalitis (CTBE) and 23 – mikst-infection (CMI) three age groups in late regenerative (6–12 months) and remote (till 2 years) the periods is investigated operative. The greatest is taped message comprehension quality indicators of a long-term memory and parameters of proof assay of Burdon. In the remote period сognitive disturbances were taped at all convalescents, prevailed at CMI and in III age group. Obtained data can form a basis for an expert estimation of state of health CTBE and CMI and prove medicamental correction at a stage of a dispensary observation.

144 patients with dyscirculatory encephalopathy (DE) I and 386 patients with DE II were investigated. The control groups included 76 subjects with no cerebrovascular disease. From neurologycal and neuropsychologycal tests and multyspiral computer tomography and electroencephalography it was exposed that vascular mild cognitive impairments have dysfunction from neuroregulation. Neurophisiological and neurovisualisation exponents have diagnostic information from vascular mild cognitive impairments.

Study of the pancreas of the rats at different periods deadaptation to valley, after 60 day adaptations to mountain has revealled significant change, which at the first periods of the study (7, 15 day) were concluded in edema stroma, inflammatory round cells, plethora container and grousing connective tissue between share and around acinus. At late periods of the study dominated change, expressing grousing connective tissue stroma ferrics with atrophy acinus parenchyma and dystrophic change acinous hutches (picnosis, vacuolization of cytoplasm). Deadaption has found the weakening an compensatory reaction with prevalence destruction processes in pancreas.

It is revealed, that pathological changes in the plasmatic and platelets-vascular part of a hemostasis are expressed to a lesser degree in the acute period of the lacunar stroke in comparison with a nonlacunar stroke. Safety of antithrombotic properties of a vascular wall in the given subgroup is confirmed. Dis - tinctions in the hemostasis profile of various pathogenesis types of strokes disappear in the early regenerative period of stroke, lasting haemostatic activation with hyperfirinogenemia, and increase in markers of thrombosis, strengthening of spontaneous platelet’s aggregation, as well as increase of level of a marker endothelium dysfunction remains with the expressed decrease in reactance endothelium.

Determinants of quality of life (QL) in migraine remain unclear. We studied QL in 70 migraine patients and 10 healthy subjects. QL in migraine strongly correlated with passive coping strategies preference, levels of anxiety and depression. Conclusion: patient’s personality determinates QL in migraine.

The sympathetic skin response and the spectral analysis of the heart rate variability at 25 patients with a tumor of a brain, at 39 patients with chronicle vessel encephalopathy, and also at 30 healthy examinees with the help of a computer complex "VNS-spectrum" are investigated. Quantitative shifts and the sign differences significative of change of descending influences of the suprosegmental vegetative centers, with imbalance sympathetic both parasympathetic nervous systems and humoral the channel of the regulation, distinct from norms, and also patients differing between groups a tumoral and vascular pathology are established. Changes of separate parameters are supplemented with distinctions within the group correlation mutual relation between parameters of the spectral analysis variability an heart rhythm.

The content of noradrenaline in blood serum in 28 children 6–16 years of age with tic disorder was analyzed. It was detected reliable descent the content of noradrenaline in blood serum of the children with a tic disorders compared the group of healthy children. Authors suppose that metabolism of noradrenaline takes part in pathogenesis of tic disorder, emotional and behavioral disorders.

Adenomas of pituitary (AP) make up about 10% of all intracranial tumours, which are met in practice of an endocrinologist or neurologist. As a rule AP are sporadically, however one must not consider them as an isolated disease. 52–62% of patients with hyperprolactinemia have AP. According to the data of. Federal Several of state statistics of the Russian Federation (2006) the amount of sick people with hyperprolactinemia among adult population can very from 214 thousand to 2 million people. About 80% make up young women at the age of 24–40 years old. 25% AP do not show superfluous hormonal secretion, they are clinically hormonally inactive, that embarrasses early diagnosis. In Novokuznetsk more than 50% of volumetrically brain formations make up AP. For last 10 years primary diseases AP has increased in 1.6 times. In Novokuznetsk there are factors increasing risk of forming of different neuroendocrinal diseases, high quantities of individual and population risks of oncologist pathology, deterioration of reproductive health, high levels of invalidism of population at able-towork age because of environment pollution and harmful work conditions. The examinations of expansion of AP disease at citizens of town Novokuznetsk show the necessity of introduction of register of dispensary for this category of sick people.

On examination of 58 people with accurate amyotrophic lateral sclerosis the role of some risk factors in the development and the character of the flow of the disease was analyzed. The received findings don’t allow excluding the participation of the viruses of herpes and cytomegalovirus in the emergence and development of amyotrophic lateral sclerosis. The particularities of the flow of amyotrophic lateral sclerosis because of the level of specific antibodies of the class G viruses of herpes and cytomegalovirus were not revealed.

The etiology of multiple sclerosis (MS) is not known still. Family cases of MS could prove the genetic predisposition for this disease. We describe here rare for Perm Region family history with three cases of MS in one generation which are characterized by significant clinical polymorphism.

In the sanatorium setting a research was conducted. It dealt with the effectiveness of the ozone therapy among the patients of perimenopausal age who have the discircular encephalopathy of the first and the second stage. Two groups were singled out against the scope of the therapy. The basic group included 50 patients, who beside the multimodality sanatorium therapy of the discircular encephalopathy got 1 course of the ozone treatment and phyto oestrogen Klimadinon. The other group, consisting of 42 patients, in comparison to the first had only the multimodality sanatorium therapy. The higher effectiveness of ozone therapy treatment among the patient in the basic group was proved according to all criteria.

To upgrade the results of surgical treatment in patients operated on for gerniated intervertebral disk the reflex-pain syndromes of spondylarthrosis and osteohondrous was studied. Before surgical treatment alcohol-novocain blockades have been used to perform denervation of intervertebral discs and joints. The reflex-pain syndromes was evoked by solution injection and then arrested by alcohol-novocain injection. Clinical outcome in long-term period after surgical treatment became good in 89% (p < 0.05) on cervical spine and in 84% (p < 0.05) lumbar.

The goal of the research was studying the manifestations of toxemic and complex immune syndromes in patients with malignant cerebral tumors, and also studying the possibilities of correction of such syndromes by means of the programs for infusion-desintoxication therapy in combination with plasmapheresis. Application of haemodilution and preliminary-prepared autohaemocomponents for compensation of blood loss at surgical interventions, promotes for decrease of toxemia manifestations and complex immune syndrome in the nearest post-surgery term.

Psychodiagnostics has various evaluation methods of psychicprocesses, characteristics and mental conditions. It is important to define the actual emotional condition and learn whether a patient has the depressed disorder. This is especially important if to take into consideration the possibility of the psychoemotional disorders correction works. The aim of the given research is to select the methods to diagnose a man’s emotional sphere. The chief task of the research is to reveal the most efficient methods to define the changes in a patient’s condition after the psychocorrection work took place. As a result of the experiment we have found out that an anxiety, connected with the adaptation period to the diagnosis of disseminated sclerosis, can be easily cured. And this fact contributes to standardization of emotional estimation while perceiving a man his or her life. These results are confirmed by the hospital scale HADS that we have chosen to demonstrate the real indices changes. The present researches can be useful in a psychological assist at neurological department.

177 patients with clinical manifestations of thoracocervical osteochondrosis with vertebro-cardial syndrome and ischemic disease of heart were inspected. 94 patients (main group) underwent a course of intraosteal blockades, while 83 patients (control group) underwent a course of paravertebral blocades. Higher therapeutical effectiveness of intraosteal blockades in treatment of the given patients compared to paravertebral blockades was revealed. Osteogenetic factor can be considered a universal mechanism of forming spondilogenic cardio-cerebral disorders.

Article is devoted to studying of the long-term results of manual therapy of early manifestations of perfusion insufficiency (EMPI) vertebral-basilar system (VBS) in children. At clinical inspection of 97 patients in 3 years after treatment relapse EM of VBI has been revealed at 28 patients (28.9%). The principal causes of relapse EM of VBS were relapses of rotational dislocation С1 and muscle spasms of a neck in a combination to relapse of the carriage disorders and hypermobility in cervical department of a backbone.

Autonomic dysfunction of cardiovascular system in children and teenagers is described. The main causes of the arterial hypertension are found out, the importance of division of arterial hypertension on the primary and secondary is emphasized. Arterial hypertension in examined children is accompanied of syncope states, difference kind of arhythmias and heart conductibility. The syndrome of dysplasia of connective tissue was found out in these patients with arterial hypertension more often.

The morphologic functional characteristics in middle and elderly aged women with ischemic stroke were examined. It is shown that disease difficulty and disablement group definition may be explain by oestrogen deficit – one of risk factors.

The goal of the research was studying the key mechanisms of pathogenesis of toxemic and complex immune syndromes in patients with malignant cerebral neoplasms, and also studying the possible ways of correction of such syndromes.

The relation between the clinical presentation of the chronicle cerebral ischemia and condition of reactions of lipid peroxidation during the prolong treatment is found out. It is characterized the reduction of the intensity of the lipid peroxidation and substantial increased of the level of the both enzymatic oxidation preventives and non enzymatic oxidation preventives.