Surgical thyropathy correction is inevitably accompanied by specific change s in hormonal status. We have analyzed the ada ptation mechan - isms and compensat ory and adaptive reactions responsible for the whole life-support system of organism. On the basis of a number of organism homeostats nonspecific mechanism s of resistant and tolerant realisation strategies of long-term adaptation were studied, suppositions were made on possible effective course of adaptation reactions in the conditions of healthy thyroidal issue transplantation and cellular therapy use.

The method of stabilography was used to study the equilibrium function in students with vascular heart diseases and diseases of musculoskeletal system going in for exercise therapy (ET). The organization of physical training with the use exercise therapy favors the normalization of the equilibrium function and coordination abilities, and the effect is more pronounced in the group of students with diseases of the musculoskeletal system.

Retina of rats OXYS 6 months of age by treatment of 4-methyl-2,6-diisobornylphenol (dibornol) was researched. Mainly, rats OXYS have of vascular disturbances such as reduction open functional vasculars of choroidea, destruction of retinal pigmental epithelium and retinal neurons. Dibornol was protected of retina increased area of open vascular and safety of retinal neurons. Besides dibornol was prevented thrombosis in retinal vasculars.

There have been defined IL-4, IL-10, IL-17 and IFN-γ in cell-free skin exudate in 90 patients of atopic dermatitis depending on spread of dermal pathological process. There been found that variations of each cytokine had different features and reflected different parts of immunopathogenesis of the disease both in an acute period and remission and after allergenspecific immunotherapy.

In our own experience we examined a functional condition of kidneys and urokinase activity of urine at 105 newborns and children of early age with congenital anomalies of the kidney and urinary tract. Inspection was spent at all newborn children after revealing of anomalies of uric system by means of ultrasonic diagnostics. It is established that functional infringements of kidneys at children with congenital anomalies of the kidney and urinary tract have certain sequence: decrease urokinase activity of urine, formation tubular dysfunctions, infringement glomerular functions of kidneys.

The objective of the given study was to assess statistic dependence of histomorphometrical values of left ventricle (LV) and right atrium (RA) auricle myocardial condition in normal hearts (17 cases) and in hearts with chronic heart failure (CHF) (21 cases). Statistic dependence between morphometrical parameters in LV, RA auricle as well as between these heart parts in both patients without cardiovascular pathology and in patients with CHF was found. In the latter group the amount of correlations decreases in left ventricle and increases between the parts (LV and RA) in comparison with the norm.

In this article the structure-mechanical properties research results of «Kartalin» ointment are being cited. This ointment shows the evident treatment-preventive activity with occupational and combinational dermatosis. It has been ascertained that the «Kartalin» ointment, being under consideration, appears to be structural liquid with expressive non-Newtonian flow character that is having high viscosity (100—200 Pa/s) and high yield point (20—40 Pa) with the temperature of usage 30—40 °C, which provides long skin protection. The flow properties of the composition are sufficiently time stable, which enables good preparation quality maintenance during long-term storing.

Biomechnic peculiarities of the technique of shots in football have been studied. With the aid of electromyography and stabilography, 45 men aged from 18 to 27 were examined. It has been shown that stabilographic and electromyographic characteristics of ball shooting can serve indicators of technical development of sportsmen. The technique of direct kick is formed at the stage of perfection of basic skills, while that of lateral kicks is formed at the stage of top sport mastering. In football players of high qualification, the role of the visual analyzer in equilibrium control is insignificant, while in low- and moderate-qualified players, the equilibrium function works worse without visual control.

Results of study of vegetative regulation in endometriosis have been presented in women at reproductive age with anxiety and depressive disorders. Obtained data demonstrate reinforcement of activation of central contour and growth of sympathic regulation in endometriosis in women with anxiety and depressive disorders what testifies to significant tension of regulator systems and critical state of adaptive mechanisms. Results of the investigation have allowed revealing the distinctive associations between psychopathological manifestations and vegetative disturbances in studied pathology.

The analysis of gene polymorphism plays an important role in assessment of disposition to infectious diseases at the population and individual level. In this paper, the frequencies of allelic versions of apolipoprotein E and 2nd type superoxide dismutase genes and the corresponding genotypes were determined in healthy persons and chronic viral hepatitis type C patients of the Europeoid population of the Tomsk Region. For the analysis of polymorphism of these genes, we used modern genetic methods: polymerase chain reaction and polymorphism of lengths of restriction fragments. For the studied population, it was revealed that the polymorphism of apolipoprotein E and 2nd type superoxide dismutase genes correlates with the development of chronic viral hepatitis type C and with the fibrogenesis process.

We evaluated some biochemical and immune parameters, such as IgA, IgM, IgG, CIC, phagocytic index, T-lymphocytes, as well as avidity of antibodies in type 2 diabetic patients.

Avidity, high- and low-avid antibody ratio was determined by test-systems for express-diagnostics of clinical and preclinical forms of immunologic deficiency. All patients (n = 47), depending on the level of glycemia and disease duration were divided into 3 groups: in the stage of compensation, subcompensation and decompensation. Control group included 17 healthy subjects.

Value of high-avid antibodies in diabetes mellitus patients decreased in 75, 57 and 26% respectively, whereas in healthy subjects it is 89%. Conversely, increased amount of low-avid antibodies was observed, respectively 25, 43, and 74% (11% in control).

These parameters prove antibody-folding disorders in diabetes mellitus and show that, change of metabolic parameters affects antibody avidity: G class high-avid antibody level decreases and shows weak protective function. This indicates functional disorders in B-system immunity.

Benign vocal fold lesions is the largest group of larynx diseases. At the present time the fundamental principle in treatment of benign laryngeal lesions is the combined therapy including surgical, medical and phonopedic methods of voice rehabilitation by indications.

Factors of adaptation to conditions of the educational environment for civil and military students have been studied. By the end of the education, the number of military students classified to the 1st health group increased by 5% and the number of military students classified to the 3rd health group decreased by 3%. Among civil students, the number of persons classified to the 1st health group decreased by 4%. The state of students’ health is significantly affected by social and psychological factors related to the education, in particular, academic load, disturbed sleep, psychoemotional stresses, relations with teachers. In formation of students’ groups, the emotional component is especially important for undergraduates, while the cognitive and behavioral components are important for graduate students.

The article contains information about Koch-Metchnikov Siberian Competence Centre which deals with the problem of infectious diseases. It is a new structural division of Siberian State Medical University which was founded in 2008 on the initiative of the university administration together with a German social institution — Koch—Metchnikov Forum. The article describes backgrounds of the foundation of Siberian Competence Centre, its main aims, tasks, the most perspective areas of Russian-German cooperation in the sphere of fundamental and practical medicine, results of the joint scientific-educational activity as well as outcomes of implementation of the program of experience and knowledge exchange in the network of professional trainings, international conferences and seminars.

In the review ways and mechanisms of formation nitric oxide are considered. Effects metabolite nitric oxide in regulation of an allergic inflammation are analysed. The modern given participations nitric oxide in formation oxidative and nitrosative stresses, in regulation of the basic endocellular alarm ways, to realizations pro-and antiapoptosis effects.

The review is devoted to the methods of bioimmunotherapy of oncological pathology used in the clinic for the recent 20—25 years and, to the higher extent, the principles of cellular immunotherapy of cancerous epithelial tumors of the digestive system. The surgical method is recognized as a «gold standard» in the therapy of the digestive system cancer. Bioimmunotherapy of the digestive system cancer has not achieved the sufficient clinical efficiency. In this connection, new pathophysiological approaches to biotherapy of the digestive system cancer based, in particular, on original results of Russian scientists are analyzed.

The psychopathological pattern of the postwithdrawal state in opium addiction patients is discussed. The pathological addiction to the drug in dependence of premorbid personality characteristics and the inverse dynamics are analyzed.

A new method of treatment of endogenous uveitis have been developed. The method is based on the application of metabolic plasmapheresis with ozonization of cellular weight. Comparative analysis of the treatment results of three groups of 179 patients (209 eyes) has revealed significant superiority of original modification of plasmapheresis. The effect of the presented method of treatment, in authors’ opinion, is caused by immunomodulating effect of plasmapheresis and ozonotherapy, bactericidal and antiviral effects of ozonotherapy. The paper also presents some sanogenetic mechanisms of a new method of treatment – a liquidation of T-cellular immunodeficiency, a decrease of level of circulating immune complexes and some others.

The development of new methods for treatment of chronic opisthorchosis patients is very urgent in regions hyperendemic in this disease. The use of phyto- (ecorsol) and physiotherapeutic (magnetotherapy) method in the combined therapy of this disease is promising and significant. These methods have the sufficient antihelminthic effect (up to 85,0%) and positively affect the indices of the motor-evacuation function of the biliary excretion system (1,2—1,3 times decreasing the volume of cystic bile and 1,7—2,1 times increasing indices of the contractile function of the gall bladder) and the level of adaptation capabilities of an organism (increasing the number of patients with the activation reaction by 16,7—33,4%).

Based on materials of combined anthropogenic enquiry of 2 620 men and 380 women, which included fingerprint and palmprint records, relations between dermatoglyphic and descriptive external characteristics have been studied with the aid of various statistical methods. The obtained data can significantly extend capabilities of expert examination concerning the criminalistic and medicolegal anthropometric identification in operational investigations.

In this article the postovariectomic syndrome is regarded as prediction of metabolic syndrome in women of different age groups. With various clinicodiagnostic analyses it has been estimated that in women with postovariectomic syndrome over 40 metabolic disturbances are observed more frequently.

A method is developed for the treatment of elderly hypertension patients. The method consists in the combined use of peaty mud applications on lower limb regions, magnetolaser therapy, and electrosleep. The investigation involved 88 patients with the verified hypertension diagnosis. It has been found that the combined medical rehabilitation exerts the positive effect of the main links of pathogenesis, improves the adaptation abilities of an organism, and thus increase the efficiency of treatment and the patients’ life quality.

Scin neoplasms are among the most common oncological diseases with the prevalence of basalioma. The paper рresents statistical analysis of the data of skin cancer morbidity and mortality rates in Krasnoyarsk Region summarized for the period since 1999 until 2007. In structure of the skin cancer morbidity defines a share basalioma and squamous cell carcinoma.

Fyodor Fyodorovich Tetenev (to the 70th birthday).

To blessed memory of Lavrova Valentina Stepanovna.

To blessed memory of Kravets Yelena Borisovna.