When the cerebrovascular patology exists, the interstitial fluid decreases. Because of that the area of the brain decreases and the area of the ventricles increases.

42 patients with dyscirculatory encephalopathy (DE) and 42 patients with Alzheimer desease were investigated. From neurologycal and neuropsychologycal tests and multyspiral computer tomography and electroencephalography it was exposed that vascular mild cognitive impairments (MCI) have dysfunction from neuroregulation and leucoareosis and lacunar inpharcts and hydrocephalia. Alzheimer desease MCI have cortical brain atrophy.

107 patients with discirculatory encephalopathy were examined. The main syndromes of the disease were a mild cognitive impairment, vascular parkinsonism, pseudobulbar, ataxia. Сorrelations between level cholesterol, lipoproteids low density in the blood with extent of atherosclerosis in the carotid artery and cognitive functions were analysed. The presence of atherosclerotic plaques, not thicking of intima-media complex, correlates with changes of memory and attention.

Аutonomic dysfunction and psychic tension have both and several properties. Anthropometric measurements, research of vegetative tone and vegetative reactivity, research of neurological status were conducted.

In order to improve multiple sclerosis (MS) diagnosing and specify the influence of climatic and geographic factors on the clinical picture of the disease, the peculiarities of its course and clinical polymorphism in the population of Rostov region were studied. The analysis was conducted to compare the main characteristics of MS in Rostov Region (prevalence — 27,2 : 100 000 of its population) and the area with a considerably bigger rate (Novosibirsk — 54,36 : 100 000). The distinctive peculiarities of the disease among people living in the South of Russia (on the example of Rostov Region) are slow progression and wide clinical polymorphism.

A new method of forecasting the outcome of ischemic stroke in the acute period, based on dynamic monitoring of new indicators of autonomic regulation of cardiovascular system — VIB (vegetative indicator of blood circulation), BSB (background systolic blood pressure), IDD (index of diastolic pressure). VIB allows to quantitatively assess the state of autonomic tone of the cardiovascular system, and to evaluate its dynamics, comparing with the physiological state of the patient. BSB — background systolic blood pressure, a quantitative method of assessing the standard systolic (pressor) load. IDD — an index of diastolic pressure — a way to assess the proportionality of hemodynamics. A retrospective analysis of 131 case histories of patients with ischemic stroke favorable outcome. The expression of VIB on admission and the normalization rate with the seriousness of the disease.

The interstitial fluid drains from the cerebral hemisphere to the same named deep neck's lymph nodes in perineural spaces. The spinal liquid drains from the subarahnoid spase to left and right neck area's lymph nodes.

According to the data of the investigation it was established the connection between the intensity of neurological and cognitive disturbances, psychoemotional disturbances and changes of quality of life of the adult and elderly patients with chronicle cerebral ischemia. It was showed that using the rehabilitation therapy in the special referral medical center in the beginning stage of the disease bias for the better on quality of live of the patients.

Neuropsychological research and analysis of level testosterone and estradiol among men and women at age from 50 to 60 were carried out. Two groups were formed. The first group was of patients with complaints bad memory and concentration, and the second group was of patients with out any complaints. The change for certain of results the neuropsychological tests between two groups of patients were fixed. The results of long-term memory were more sensible. The correlation between different level of testosterone and results of neuropsychological tests among men and women was fixed. The correlation between level of estradiol and results of neuropsychological tests was not fixed.

For the study of effect neurovegetative blockade of the brain on the course of an stroke in the acute period was carried out noninvasion monitoring of the basic parameters systems haemodinamic and a vegetative homeostasis with use of Kerdo Index at 110 patients with different types of stroke. The neurovegetative blockade having been started in the first day of the brain damage promotes the decrease of damaging reactions manifestations, normalization of vegetative homeostasis and promonting more favourable course of acute period stroke and its prognosis.

The paper presents the results of the analysis of nasal cavity and stomatopharynx condition in the group of patients with multiple sclerosis. Microflora, immunological status and inflammatory changes of mucous membranes are studied. In the group of patients with multiple sclerosis the frequency of dysbiotical changes and chronic ENT diseases is higher than in the group of comparison. The correlation between frequency of dysbiosis and immunological status disturbances is shown.

Alleles frequencies and polymorphisms genotypes frequencies of gene DRD4 (VNTR), gene DAT (VNTR), gene 5-HTT (VNTR and ID) and gene OPRM1 (SNP) were investigated at Russian males taking narcotic substances. It was determined that genotype 4/3 occurs only at persons taking narcotic substances, the most often occurring polymorphism of gene DRD4 is genotype 4/4 in all groups. It was detected that the polymorphism of gene DAT at narcotized persons is presented by the high enough part of genotypes 9/10 and 10/10, but in the rest of groups the distribution is the same. At narcotized persons and in the control group, the carriers’ part of genotype I/D of gene 5НТ2А is high. The genotype D/D occurs only at persons taking narcotic substances. The genotype10/10 of gene 5НТ2А occurs more often than in population group, which conforms to the literature data.

In 1992 Kemerovo region in the Russian Federation was first admitted as the area with an extraordinary ecological situation. Living in Kuzbass is factor of risk of forming of different endocrine diseases, deterioration of reproductive health, high quantities of individual and population risks of oncologist pathology, high levels of invalidism of population at able-to-work age because of environment pollution and harmful work conditions. The present study includes 299 sick people with confirmed diagnosis of adenomas of pituitary in the endocrine department of the town hospital № 1 for the period from 1995 to 2007 that is complete selection. Adenomas of pituitary are more often detected at people at active able- to-work age. Adenomas of pituitary are more often diagnosed at women 87,0%. The overwhelming majority of adenomas of pituitary (74,0%) is detected at the age of 20—50. Because of this disease 99 people (33,1%) have different degree of loss of their working ability. In the structure of adenomas prolactinomas dominate (53,5%), on the frequency of meeting hormonally inactive adenomas are on the second place (32,1%), somatotrophinomas are rarely met (in 11,7%) and the rarest ones at the population on Novokuznetsk are corticotrophinomas (in 2,7%). On dimensions of adenomas of pituitary microadenomas predominate — at 68,0% sick people. The relation microadenomas to macroadenomas is 17 : 22 at men and 187 : 73 at women.

78 patients with motor neuron disease (MND) were examined. Prevalence of MND in urban population of Novosibirsk on 2008/01/01 is 3,46 per 100 000 of population. In majority of patients amyotrophic lateral sclerosis (ALS) was revealed — 76 people (97,4%); primary lateral sclerosis was revealed in 1 case (1,3%), progressive bulbar paralysis was revealed also in 1 case (1,3%). There were 63 men (80,8%) and 15 women (19,2%) (ratio is 4,2 : 1,0). There was no people younger than 27 years for the moment when first symptoms of the disease were revealed. The major age group was 41 to 60 years (66 people — 84,6%).

The paper shows conception of integrative ageing of organism based upon complex approach and clinical-and-psychological, clinical-and-neurophysiological and neuroimmunological studies. Spiritual-and-psychic and genomic spheres of activity play major role in ageing and combine nervous, endocrine and immune systems. Controlling systems take part in pathological process that’s why there have to be integrative attitude with accent on spiritual-and-psychic and genomic spheres. Spiritual dominant in man’s life is the basis of health harmony and active longevity.

Precise diagnostic of hereditary muscular diseases begins to change during recent years due to genetic achievements. Genetic defects discoveries typical for different clinical variants of muscular dystrophies give opportunity for creation of specific testsystems to verify the diagnosis. Determination of gene and protein causes of neuromuscular pathology however does not exclude initial clinical diagnostic which cost less and easier to find.

Progressive supranuclear palsy related to neurodegenerative diseases of the brain. In the pathological process involved, and stem structure. The disease manifests a combination of progressive akinetic-rigid syndrome and early development of postural instability leading to frequent falling. Observed supranuclear ophthalmoplegia, pseudobulbar syndrome and dementia of frontal. Arises at the age of 50—60, rapidly progressive, and untreatable protivoparkinsonicheskimi drugs. An clinical case of a patient 59 years old, with these magnetic resonance imaging of the brain.

Value of functions of the vestibular analyzer of the child in formation of its motility is shown. 11 patients aged till three years, suffering by a childrens cerebral paralysis, have been surveyed. Was studied the group of the tonic reflexes in dynamics, afferent arch of which was the vestibular mechanism and its conductors. Infringement of degree of expressiveness of tonic reflexes and their late reduction are a principal cause of formation of a pathological impellent stereotype at the child.

We investigate vegetative regulation heart activity by 15 patients with temporal lobe epilepsy and 15 with syndrome vegetative dysfunction. We detect increase sympatic tonus at rest and low arousal sympatic part by realization orthostatic test by patient with vertigo central genesis as against with healthy. It is our belief that detect disturbance related to implication in pathological process suprasegmental part statokinetic analyzator.

With purpose of studying of social adaptation in patients with pain syndrome recurrence in the discectomia distant period were 215 patients investigated. Study methods included neurological examination, magnetic resonance tomography, rentgenography, ultrasonography, Osverstry query. Reasons of pain syndrome recurrence were revealed. It was ascertain, that the pain syndrome recurrence is accompanied by social desadaptation. Participation of social specialists in adaptation process is recommended.

Аmong patients DM of type 2 (DM 2) Altay territories the stroke is at the bottom of death in 4,1 times more often, than among the edge population. A research objective: to estimate and compare a role of various risk factors (RF) in occurrence of a stroke at patients DM 2 sick of a diabetes according to register DM 2. Assumed RF in the basic group (patients prevalence was compared to a stroke) and in comparison group (patients without a stroke) with calculation of the odds ratio of development of a stroke. Were compared statistically significant RF developments of a stroke 2005 and 2008. Studying RF of a stroke at patients СД of type 2 and work carrying out on decrease in force of their influence, has allowed to level influence of one of the most significant risk factors of development of a stroke in 2005, late diagnostics blood pressure that has resulted in 2008 in decrease in death rate from a stroke among patients DM 2 on 24,9% more than among the population of Altay territory.

N-butyl cyanoacrylate (Hystoacryl) is one of the most frequently used glues for the treatment of cerebral arteriovenous malformation. However, long-term results of its treatment with Hystoacryl are insufficiently studied. 136 patients were examined. Catamnesis was (4 ± 1) year. The quality of life is reduced due to cognitive and motor disorders.

Forty women with climacteric syndrome took part in a prospective research. Strong vegetative dysfunction and increased anxiety and light situational or neurotic type depression (30% patients) were found. Health related quality of life increased after correction of these disorders with Estrovel — product, containing combination of standardized medicinal herbs extracts.

The aim of the study was assessment of gait parameters with a laser range finder use in patients with cerebellar ataxia syndrome. There are reliable differences in the relative stride length and stride variability coefficient for the patients with ataxia in comparison with the healthy middle aged people was found.

Stroke is the acute medical and social problem, because this disease has high level of mortality and invalidization. There is a special regional program «High quality medical care organization in Tomsk Region in 2007—2009». The most important measure of this program is «Stroke center» organization in Tomsk Regional Hospital.

Preliminary analysis of special regional program «High quality medical care organization in Tomsk Region in 2007—2009» efficiency shows a significant improvement of all types medical care organization in patients with stroke. General rate of mortality in patients with stroke, ischemic stroke mortality rate and subarachnoid hemorrhage mortality rate has been decrease in «Stroke Center» for last three years.

Analysis of indices «Stroke Center» activity allows to denote the nowadays problems and prospective of future improvement of medical care in patients with stroke have been revealed.

According to the anamnesis data 38% of multiple sclerosis patient population had neuritis retrobulbaris as the first clinical symptom. The examination of visual evoked potentials detected that 88% of patients who had suffered from neuritis retrobulbaris earlier, and 19% of those, who had not, had changes revealing possible subclinical demyelinization of a visual nerve.