The lecture presents basic directions of molecular medicine development. Special attention is devoted to prior direction of identification of molecular and genetic markers of predisposition to chronic course of socially important viral infections, development of molecular basis for personalized therapy and outcome prognosis of interrelations between an infect and a human. Analysis of literature data concerning the discussed prob lem and also the results of proper investigations are presented.

Absorption function of small intestine concerning fats, proteins, carbohydrates in 68 patients having chronic obstructive pulmonary disease (COPD) was studied in comparison with trophologic insufficiency. Thirty five patients were controls. Absorption was studied based upon van de Kamer method, by radioisotope method and d-xylose test. Decreased absorption was revealed in patients with mean severe and severe COPD. Direct correlations were established between body mass deficiency in COPD patients and decreased absorption function of the small intestine as concerns proteins (r = 0,71), fats (r = 0,55) and carbohydrates (r = 0,48).

Pathomorphological investigation of influence on rat’s internal conditions, that were subjected to injection of medication called kumasid for prophylactic immunization extracted from Cucumaria japonica was made. It was determined that the kumasid medication dosed 1—100 mkg/kg administrated to rats intragastically during three monthes doesn’t influence on internal conditions of rats.

The immunohistochemical study of skin was conducted to verify presence of p53, bcl-2 and bax apoptosis markers in epidermal keratinocytes of patients from two age groups: 16 to 44 years old and 45 to 64 years old. It was discovered that with chronological ageing of skin the expression levels of p53 and bax apoptosis markers are raised by epidermal cells in patients of elder age group. Obtained data testifies to cumulative damaging effect of a quantity of proapoptotic factors (oxidative stress, UV-waves, ionizing radiation, chemical reagents etc.) on epidermal cells with ageing.

This article is presented whith the results of comparing assessment of clinical efficiency and medicine portability. This medicine is a stimulator of hematopoiesis (poetam-medicine which contains affinno refined antibodies to human recombinant erythropoietin). Besides there were rep resented the results of treatment with iron-containing medicine (Sulfate of iron 325 mg) which helps in case of anemia which is a consequence of juvenile uterine bleeding in puberty.

The method of electron microscopy and morphometry have been used to study peculiarities in formation of the structure of human embryo and fetus brain synapses at early stages (7 to 12 weeks) of development at mother alcoholization. Electron microscopy of material obtained from alcoholic women has shown slowing-down of formation of synaptic structure. Morphometry has revealed that under the influence of prenatal alco holization the formation of components of synaptic brain contacts slows down at 9—12 th weeks of development: the area of presynaptic terminals and their perimeter decreases, and the perimeter of postsynaptic densities decreases as well.

The aim of this work was to study the roentgen-and-morphological dynamics of reparative regeneration for the experimental substantiation of treating a transverse (central) acetabular fracture with femoral head subluxation by the method of transosseous osteosynthesis. Experiments were performed using 11 mongrel dogs, both males and females. It has been established that after setting a femoral head into the acetabulum, precise reposition and fixation of its fragments the bone union in the fracture site is achieved within 35—65 days.

A number of investigations revealed a problem of osteopenic syndrome in patients with multiple sclerosis but there is no common opinion concerning factors which lead to its development. We observed 65 patients with multiple sclerosis with various type of its course and disability status of several degree based upon EDSS scale. Ultrasound osteometry of the calcaneus, computer tomography of QCT of L1—L3 vertebras were performed, serum crosslaps, N-MID osteocalcin were used. Decreased bone density, injured bone microarchitectonics and suppression of bone formation and resorption, which were correlated EDSS were found. Correlations with other factors (growth, weight, gender, and number of steroid therapy sessions ) for these parameters was not revealed. This allowed to conclude that the main reason of decreased bone mass in patients with multiple sclerosis is the dramatic decrease in physical activity.

The purpose of the investigation is the definition of numeral meanings of the Young’s module on the central part of cataract in vitro. The experiment was carried out by the method of penetration on 108 lenses of a human eye with the help of the developed original device. It is revealed that the area of resilience display is within small limits of unit strain. The Young’s module is within 2 MPa to 6 MPa and depends on the density of a lens nucleus (III—V) according to Buratto.

Язвенные гастродуоденальные кровотечения, пожилой и старческий возраст, эндотоксемия

Medical activity, which always includes the necessity to solve a system of logical, gnoseological, axiological, and praxiological problems as sociated with the process of diagnostics and treatment of a patient, can be successful only with high culture of a specialist. It is a moral obligation of a medical practician to become a man of culture. Based on a systematic approach, the paper presents medical culture as a specific subsystem of general culture, whose mastering starts in childhood, develops in university, and continues for the whole life, demanding colossal mental ener gies. Part 2 reveals the content of world outlook and philosophic-anthropological aspects of medical culture, grounds the necessity of the revise of the existing anthropological paradigm.

The use of nanomaterials offers many advantages due to their unique properties. They can be used as building blocks for the fabrication of various functional diagnostic systems and agents of therapy. This article focuses on the application of magnetic nanoparticles in biomedicine such as magnetic separation, biosensor, contrast agents for MRI (magnetic resonance imaging), local operated hyperthermic treatment of tumors, drug delivery, gene therapy, tissue engineering.

The complicated ratios of clinical symptoms of internal lesions during central lung cancer are demonstrated in the article when changes of differential diagnosis tactics were required for diagnosing that necessary keeping is priority of the clinical appraisal of the results inspection patient.

A comparative analysis of the premenopause and postmenopause course was carried out in women with cerebral circulation ischemic disor ders (group I) and in women without the signs of the cerebral vascular impairment (group II). The study included the evaluation of the anamnesis, objective status, functional state of the vegetative nervous system, asthenia as well as laboratory and instrumental examination methods. The analysis of the obtained data showed that cerebral circulation ischemic disorders in women contribute to earlier manifestations of the climacteric syndrome with a marked clinical picture presented by neurovegetative, metabolicendocrine and psychoemotional disorders as well as high fre quency of asthenic disturbances of predominantly hypostenic type.

Results of treatment of 103 patients with posttraumatic osteoarthritis complicated secondary synovitis of knee and ankle joints are presented. Rehabilitation programs in comparising grops included the treatment by common aquatic radon baths, their comdinations with magnetic-lazer therapy, assotiation common radonotherapy and local a-therapy by radon applicator for external use. Comparatively analyzed of treatment results demonstrated high efficiency of assotiation local and common radonotherapy such as decrease activity of inflammation, reduction exudative and proliferative disorders in joints.

The aim of investigation is to study the influence of different types of anesthesia on hemostasis in proctological patients, and to develop the algorithm to determine adequate method of anesthesia to prevent hemostatic disorders. 120 patients have been investigated with new instrumental method — hemocoagulography. It has been estimated that different types of anesthesia have different influence on functional activity of hemostasis.

The task of our investigation was the analysis of enzyme activity of antioxidant defense in women blood at physiological pregnancy and pregnancy complicated with hypertension. It was established that hyper production of hydrogen peroxide and glutathione peroxidase activation at physiological pregnancy improved microcirculation due to vasodilatation effect of hydrogen peroxide. It was established that activation of superoxiddysmutase and myeloperoxidase at pregnancy complicated with hypertension developed endothelial dysfunction owing to citotoxic effects of hydrogen peroxide.

Both in the Russian Federation and in Tomsk area comes to light negative tendencies in population health: low level of indicator ADFL and the tendency of its decrease, lower level of an indicator at men, than at women. Only hardly more than half of men born in 2003 can live till 65 years, and women more than half till 80 years IADFL countrymen considerably below city, there are no bases for optimistic forecast IADFL for men.

Decreased amplitude and increased latency of visual and cognitive excited potentials were revealed in football-players in the stage of prima ry special sports training in the first year of their training process. In the second training year, this amplitude is increased and latency is decreased. Forming special physical preparing of the football-players in the stage of primary sports specialization is mutually correlated with functional changes in the central nervous system which manifested in decreased latent period and increased amplitude of excited potentials of the brain.

The history of the creation of Siberian State Medical University symbol — octahedral tower of faculty clinics — has been presented.

In the article the information about Springer and World Scientific Co. Pte. Ltd. databases is presented. The access to these databases is opened for all users of the scientific medical library of SSMU in 2008. The access to the full-text resources became possible because the projects of Russian Foundation for Basic Research were being carried out in SSMU.

Creative biography of professor, Philosophy Doctor, chief of the fundamental bases of clinical medicine chair, pro-rector on strategic devel opment and innovation policy of the Siberian State Medical University (Tomsk) N.V. Ryazantseva is presented in the article.