Hypertensive intracerebral hemorrhage - a common form of cardiovascular disease, characterized by high mortality and disability. One area in improving patient care remains the development of new minimally invasive surgical methods and devices. We describe a new method and device (funnel cannula), which after the special markings to the use of CT punktion entered into the cavity, followed by the evacuation of hematoma. In each case, depending on the depth of hematoma and its volume is cannula certain size. The device allows for a more radical removal of hematoma without significant damage to brain tissue.

There are psychologic status of patients having multipled sclerosis research results. 30 patients were involved in the research, among them there were 18 (60%) female and 12 (40%) male ones at the age between 20 and 60. Patient examination was realized by means of the Spielberger, Maudsley and Zung methods. As a result of research there are patient's psychological state changes. 66% of patients have these changes in the form of high-grade uneasiness, 50% — in the form of rigidity and introversion, 83% have depressing disorders in the form of slight depression and subdepression.

These findings expand our conception about psychological mechanisms of dissociated personality patients with multipled sclerosis have, and need various multimodal approaches for their psychological correction.

We examined of 62 patients with various types of multiple sclerosis current, which middle age has made (31,8 ± 1,2) years. It has been lead genotyping by means of PCR by a polymorphic variant 1188A/С gene IL12B in 3`-not broadcast area and has been found out not only higher frequency of alleles C of a gene IL12B in comparison with healthy persons, but also the association with more active of MS current is revealed. At the analysis of immunological parameters of patients depending on a genotype IL12B, it has been found at carriers alleles C the tendency to reduction absolute maintenance of mature T-lymphocytes and increase CD25⁺ and CD95⁺.

The stroke register having been started in Smolensk Region revealed stroke morbidity 2,38 cases and stroke mortality 1,25 cases for 1000 people in 2007. Stroke-case fatality comprised 33,4%. Hypertension appeared to be the main risk factor of stroke (81%).

Hypoxia and its related oxidate stress are the direct cause of the neural damage due to chronic cerebral ischemia. Resistance to hypoxia and oxidate stress is the main marker of the human and brain adaptation to chronic ischemia.

Hypoxia resistance and the condition of the glutation antioxidant system in the difference stages of chronic cerebral ischemia was investigated in this study. 310 patients from 35 to 55 years with the first (100 persons), second (105 persons) and third stages (105 persons)) of chronic cerebrovasculare insufficiency were examened.

Decreasing of the hypoxia resistance and resistance to oxidate stress at chronic cerebral ischemia was shown. The average figure of hypoxia resistance and functional activity of the glutation system at the different stages of the chronic cerebral ischemia shows the course of the general adaptive syndrome.

The results of clinical-and psychological study of 106 in-patients of neurological ward with acute, sub-acute or chronic low back pain are presented. We studied quality of life, anxiety, depression and correlations between them in subgroups. We conclude that quality of life and ability to work depend on both physical and emotional factors. Additional recommendations are suggested for existing algorithm of management of patients with low back pain.

Here we present the results of our study of the influence of clinical and social parameters as well as co-morbidities (as anxiety, depression, sleep disturbances) on the health related quality of life of 95patients with the most often met primary cephalgias — tension type headache. We used MOS-SF36 (Medical Outcomes Study Short Form-36) as the main instrument to measure health related quality of life. Significant influence of anxiety and depression on the quality of life in patients with both frequent episodic and chronic tension type headache was reported. Anxiety in these patients was mostly associated with psychic health, general health and vitality. In patients with chronic tension type headaches depression was associated with physical functioning; in those with frequent episodic tension type headaches — with social functioning and role functioning due to emotional sate.

Genotypes and haplotypes frequencies for VDR polymorphisms in case-control studies of multiple sclerosis (MS) were investigated. Results show an association of VDR T/t variant with diseases (p < 0,05). This marker was also associated with amount of eosinophils in MS patients (p < 0,05). Polymorphisms B/b and F/f was associated with ESR level, IgG level and amount of the CD16⁺ cell (p < 0,05). We demonstrate that the Bft haplotype significantly higher observed at MS patients and btT — at healthy person Received data allow suggests that the allele t VDR and Bft haplotype of VDR gene could increase susceptibility to MS and have influence on clinical manifestation of diseases.

The aim of the research is to investigate activation of antitumor immune response efficiency using professional antigen-presenting autologous dendrite cells in the complex treatment of patients with cerebral hemisphere malignant gliomas. We have analysed 48 cases of patients with malignant gliomas (35 — glioblastoms, 13 — anaplastic astrocytoma) who received an complex treatment with specific immunotherapy use. All the patients were hospitalized at late stage of disease and tumor size exceeded 5 sm. After the operation all the patients achieved satisfactory quality of life (not less than 80 points according to Karnofsky). Specific antitumor immunotherapy was conducted in accordance with original methodic, including autologous dendrite cells with tumor antigens and tumor cells lysate. Treatment course included intradermal introduction of dendrite cells at the 10—12 day after the operation. The treatment included not less than 3 injections. The course of treatment was repeated every 2—3 months. Specific antitumor immunotherapy included into complex treatment of malignant gliomas allows to increase disease remission, life quality being satisfactory.

Taking medical documents as a basis we’ve set up the guantity of registered of primery brain’s tumour (BT) for the period of 1966—2005 years. The data were compared with the published accounts about the average guantity of solar spots, which reflects the level of solar activity. Mathematic analysis registered some parallels of dynamic summery freguency of all varieties of brain’s tumour (BT) and the quantity of solar spots , so that the changing of tumour’s graphic 4—5 years behind. The lagging of the curve of solar activity - sometimes as far a half of the 11 years cycle — refers only to benign tumour. Changing of the level of malignant tumour closely follows the solar activity index and have line interaction which depends on solar spots.

System approach was used to determine arterio-venous correlation under hypertensive encephalopathy (HE). 250 patients with HE I—III and 30 controls matched for age and sex were examined. The clinical, ultrasonic diagnostics and quality of life (QL) index were applied. By means of ultrasonic diagnostics it was shown that in the process of HE development and progression the changes on all structural functional levels of cerebral vascular system occur. The QL analysis depending on the HE stage shown that as the disease progresses the physical constituent of health increases and the mental constituent of health decreases. In the group of patients with venous discirculation of the blood pain barrier was decreased, physical and mental health constituent were lowed.

The purpose of work was improvement cognitive functions at patients after an ischemic insult in the early regenerative period by inclusion in a complex of rehabilitation cognitive gymnastics.

123 patients in the age of from 45 till 60 years after an insult are surveyed. Sick by a method of casual selection are divided on two groups, at 61 the complex of physical rehabilitation joined regular employment cognitive gymnastics, the others 62 patients received a standard complex of rehabilitation actions. An estimation cognitive functions it was carried out with use of following techniques: the reduced multifactorial questionnaire for research of the person, «Memory for the images», «Memory on numbers», «Tables Shultie», a brief scale of an estimation of the mental status (MMSE), a questionnaire «Quality of a life» SF-36.

After a rate of employment cognitive gymnastics have improved cognitive functions: frustration of short-term memory and any attention have considerably decreased, the degree of quality of a life has raised, the mood has improved, the level of asteno-neurotic reactions and leaving in illness has decreased, the self-estimation has raised. The undesirable phenomena at one of patients during the lead treatment it has not been revealed.

Employment cognitive gymnastics are effective at patients after an insult in complex sanatorium rehabilitation owing to positive action on cognitive functions, to increase of a degree of quality of a life.

The usage of the lymphotrope therapy in patients’ with cerebrovasculas pathology complex treatment helps to readjustment of neurons’ pericellular habitat out of bilirubine and prevent the development of repeated abnormalities of cerebral circulation.

20 patients with the various forms of myasthenia were observed for the period from 2 to 10 years. There are trigger factors, features of different forms of disease described. The diagnostic criteria of diagnostics myasthenia and methods of treatment are described.

Change of political and economic conditions should change a subject and methods of social study essentially. In postreorganization Russia the purposes of the state, methods and forms of the government, a subject and methods of a science have changed «Social hygiene» Were transformed unsystematically and till today's time are not certain. This circumstance has caused crisis of social hygiene as sciences. It is necessary to define a subject and methods of a science «Public health and public health services» on the basis of the right.

We described the modern point of view in the pathogenesis of the acute and chronicle low back pain, conception of the tree components formation of the chronicle pain: nociceptive, neuropathic and psychogenetic. Whereby, it was offered the ways of the pathogenetic treatment. We described and substantiated the modern way of treatment of the back pain. We generalized the results of our own experience of using Nurophen for treatment of the acute phase of the back pain in the low part of the back. We showed the efficiency of the Nurophen for treatment of the acute pain in the low part of the back and prevention of the formation of the chronicle pain syndrome.

80 children’s were observed with infantile cerebral paralysis for searching frequency infantile cerebral paralysis and particularities functional biomehanic disordeved of children of native population (Hakass). The prevalence of the diagnosis ICP is in 6 time more in european group, as compared with hakas’s, and in 8 time more as compared with mestizo. On frequency of occurrence once forms ICP in all free groups on 1 place double hemiplegia; on 2 places hemiparesis form. Beside all children’s with ICP in 100 rate were discovered functional biomehanich damages, demanding corrections by methods manuall therepy.

Neurotransmitters disturbances with the certain role of serotoninergic system are in the basis of pathogenesis of epilepsy. 46 patients (29 females, 17-males) with idiopatic generalized epilepsy (mean age 21,8 ± 1,82) were investigated. In 30,4% of patients depressive disorders were revealed. Significant decreasing of blood serotonin level in patients with during the interictal period which decreased more after the generalised convulsive and myoclonic seasures was found by the immune assay method.

^99mTc-MIBI Brain SPECT results of 79 patients with glial brain tumors are presented in the issue. The new technique of brain SPECT with ^99mTc-MIBI was discovered and its oppotunities in characterization of tumor grade is shown in his study.

Herpes encephalitis (HE) often proceeds in the form of focal inflammatory cerebral affection resembling an abscess or tumor of the corresponding localization. Differential diagnosis of HE may be difficult, forcing diagnostics with other processes bounding the space. Case histories of four patients, in whom encephalitis foci were similar to brain-growth, are presented. Two patients were operated for removal of necrotic formations. Difficulties of diagnostics and ways to overcome them are discussed.

Morphofunctional characteristics of men of middle and elderly age with ischemic stroke have been studied. It has been shown that severity of disease is explained, among other causes, by augmenting of dishormonal disorders in patients.

The complex rehabilitation programs make an impact on physical, psychological and social aspects of quality of life of the patients with acute brain stroke. The sanatorium stage of treatment is a great important because there are a lot of harmonious combinations of drugs, psychosociological, natural and physiotherapeutic methods of influence on human body.

Tenoten was used for the treatment of discirculatory encephalopathy (stages I—II). The article shows medical effects of the Tenoten using methods of statistic analysis.

The purpose of present research is to estimate the influence of ischemic stroke on changes of clinical and instrumental parameters in patients with chronic heart failure (CHF) depending on expressiveness of neurologic deficiency. We supervised 103 patients with CHF, among them 71 patients with stroke. In all the patients twice heart rate variability and echocardiography were carried out. To determine CHF FC we used an estimation scale of a clinical condition (SHOCKS by Mareev, 2000). After 6 months all the patients were divided into 2 groups depending on expressiveness of neurological deficieny. Significant deterioration of heart rate variability (HRV) parameters in the group of patients with expressed neurological deficiency was revealed. Also in this group increase of end diastolic volume, end systolic volume and deterioration of diastolic function was revealed. 6 months after stroke in patients with CHF with expressed neurological deficiency reduction of parameters of HRV, progressiveness of hyperactivity of sympathetic adrenal system, deterioration of morphological-functional parameters of left ventrical was revealed.

The purpose of the study was to compare cognitive functions in patients with episodic tension-type headache (EpTTH) and chronic tension-type headache (ChTTH).

EpTTH was diagnosed in 34 patients in which it combined with psychovegetative syndrome in 17 persons and with cerebrovascular disorders in 28 persons. ChTTH was diagnosed in 57patients; it was associated with psychovegetative syndrome in 17 of them and with cerebrovascular disorders in 40 of them.

Difference between EpTTH and ChTTH patients was revealed only for the patients with psychovegetative syndrome. Such difference was slight and refered the tests for attention switching.. Patients with cerebrovascular disorders demonstrated worse modally non-specific problems with memory and attention and higher anxiety and depression levels that patients with psychovegetative syndrome.

Results suggest the different mechanisms of tension headache prolongation in the patients with psychovegetative syndrome and cerebrovascular disorders. The chronic tension headache itself doesn’t worse the cognitive functions while general causes exist which influence neuropsychological decline as well as tension headache stability.

A clinical pharmacological study (67 patients) was made to analyses of pseudoresistance reasons. During standard AED dose treatment, remission was achieved in 80% of the patients.

Main effects of system enzyme therapy (SET) are antiinflammatory, fibrinolythic and immunomodulating. Combination of these effects proved to be important in the treatment of 30 patients with stroke and 30 patients with ischemic cerebrovascular diseas. The use of polyfermental preparation flogenzyme in complex therapy allowed to normalize the state of thrombocytic hemostasis and to improve the indexes of plasmatic hemostasis and rheology of blood, serum concentration of proinflamatory cytokines (TNF-α, IL-1β, IL-4) to a considerably greater degree than in control group (39 patients) and impaired velocity and reactivity parameters (33 control). Thus, SET medications are necessary and very important pathogenetically in the complex therapy of patients with acute and chronic cerebral ischemia.

We have carried out a comparative analysis of peculiarities of headache at patients with adenoma of hypophis and hypotolamic syndrome of complicated genesis. 611 sick people were checked up (472 females and 139 males): 311 with adenomas of hypophis and 300 with hypotolamic syndrome. Methods of investigation: for appreciation of headache we analyzed qualitative and spatial — temporary descriptions and provokating factors. Double-sided headache at parients with adenomas of hypophis was in 2,5 more often than at patients with hypotolamic syndrome. Correlation of frequency of left- and right-side localization was also different: 1,6 : 1 — at sick people with hypotolamic syndrome and 1 : 1,1 — with adenomas of hypophis.

Quality of life is a new characteristic of health of patient, and efficacy of treatment. Quality of life had wide dissemination during last time. The aim of study was to exanimate and to compare quality of life patients with Parkinson’s disease which depended on gender, age, form of disease and cognitive impairment. We examined quality of life of 90 patients with Parkinson’s disease by questioner SF-36 and PDQ-39. Quality of life increased in patients with Parkinson’s disease, and depends from form and cognitive impairment.

Pathology of extrapyramidal nervous system (EP) is one of the most complex sections of clinical neurology. Specificity of EP disorders accounts for the necessity of specialized assistance to patients with parkinsonism, tremor, dystonias, tics and other hyperkinesias. The article gives an account of a 4-year experience of Center for Extrapyramidal pathology work, as well as its problems and achievements. A total of 1 738 patients with different motor disorders (total of 4 301 consultations) were examined in the center for the whole period of its existence. Scientific research work is carried on as well. On the basis of the experience it was found out that neurologists. Сome across considerable difficulties in making diagnosis and choice of extrapyramidal diseases treatment. We are planning to expand the use of modern techniques in diagnosis and treatment (including botulotoxin injections, deep brain stimulation), identification of epidemiology of some extrapyramidal disorders in Kazan city.

Basing on the material of 25 surgically treated epileptic patients higher mental functions were studied in the pre- and postoperative periods using certain neuropsychological tests with comparison to the clinical-electroencephalographic findings in order to localize the leading epileptic focus. Short-time auditory-dysphasic and visual memory disturbances were revealed denoting temporal lobe localization of the focus. The above disturbances deteriorated postoperatively, but during the period of 1 to 2 years they regressed to the preoperative level.

Neurological, psychological, anthropological, biochemical, and neurovisualization statuses have been studied in 200 alcohol abused patients after acute cerebrovascular pathology. It is shown that the groups of alcohol-abused patients show a more serious clinical pattern compared to the groups of patients free of alcohol dependence.

New approach to treatment of the ishaemic insult (IsI) was developed in the frame of the conception of nootropic stimulation, which include carrying out of nootropic agent (piracetam) with melaxen (analog of endogenous melatonin). For complex estimation condition of patient after IsI before treatment and after application of piracetam with melaxen methods of the quantitative analysis of EEG with the using of the multispectral indices, computed as ratio of the changing weight coefficients of spectral power in the different ranges of analysed EEG durig processes of the treatment of the patients with IsI.

The paper presents the results of the first prospective epidemiological study of stroke in Kemerovo. The stroke was primary in 77,1% patients, the second one was in 22,9% patients. The frequency of the development of stroke increased with the years. The most prevalent risk factor was arterial hypertension which was recorded in 91,6% patients. Cardiac pathology as a stroke risk factor ranked second (61,7%). Cerebrovascular disorders in close relatives were registered in 55,5% patients. One-month lethality was 41,1%.

Case monitoring of 105 infants from 1 to 12 months with 1, 2 degrees cerebral ischemia was realized. Clinical, clinical-neurovisual signs of hydrocephalic syndrome were observed in 57 patients of the first group. For 48 infants of the second group there were only neurosonographic signs of cerebrum liquor spaces dilatation. Transcranial Doppler investigation was included into case monitoring. Indices of cerebral hemodynamics determining clinical finding of intracranial hypertension were established. Principal mechanisms of cerebral hemodynamics changing under hydrocephalic syndrome for infants of the first year were found. Stable characteristics pointing to intracranial hypertension regardless of clinical finding are shown.

The study of clinical and epidemiological particularities of the extrapulmonary tuberculosis (EPT) in Novosibirsk for period since 1992 on 2006 was performed. The constant trend of the musculoskeletal tuberculosis (MST) subgroup enlargement with spine involvement (Potts disease) was revealed. Prognostic value of body type and psycho typological particularities in estimation of time consolidation for involved vertebra was proved.

To study osteochondrous and spondylarthrosis reflex syndromes in patients operated on for herniated intervertebral disks, and to develop diagnostic and treatment options.

Alcohol-novocaine blockades have been used to perform denervation of vertebral joints and dereception of mtervertebral disks in 39 patients who underwent surgical compression. Reflex-pain syndrome was evoked by solution injection into defined vertebral joint or into intervertebral disk. Subsequent anesthetic injection arrested pain syndrome justifying its provocative source.

Clinical recovery and significant improvement demonstrated 85,6% (p < 0,05) of studied patients following dereception (denervation) procedure. Long-term therapeutic effect was found to be stable.

Coeliac disease (CD) has been associated with various neurological disorders, the most common being neuropathy, ataxia and migraine. The aims of the present study were to assess the following: 1) the prevalence of migraine in patients affected by CD and 2) the effects of a gluten free diet in CD patients with migraine. 376 patients with CD had direct interviews and full physical and neurological examinations. The diagnosis of migraine was based on criteria of the IHS in 1988. The diagnosis of CD was confirmed endoscopically and by serum IgG antitransglutaminase (TgA) and IgA antiendomysia (EmA). Control group consisted of 234 patients suffering from reflux-esophagitis. The diagnosis was confirmed endoscopically. A gluten free diet was started in the patients diagnosed with CD associated with migraine, who were followed for 6 months. Migraine occurred in 161 (43%) of the 376 patients studied and in 25 (11%) of the 234 control group patients. An increased prevalence of migraine was observed in the coeliac patients. A gluten free diet may lead to an inprovement in the migraine in these patients.

The article lists brief survey on the history of the art-therapy development. The main features of application of this method of the group psychotherapy with psychotic and other hard mental patients are described. The experience of application of the group art-therapy in the general sections of the mental hospital is summarized. The uniqueness of the described studies depends on concerted actions of psychologist and artist, discussions on their results with the psychiatrists in charge of the cases, taking into account while selecting complex treatment. The method is not only extending the abilities of complex biopsychosociotherapy of the mental diseases in hospital conditions, but also promotes the better adaptation of the mental patients in family and society after discharge.

This article shows the analysis of working of the child epileptological room for 2002—2007. The goals of the room are determinate, the groups of the children, examined in the room and being registrating, are selected. Learning the example of 650 children with epilepsy, who are registrating, we found out the domination of focal symptomatic or probably symptomatic form (62,2%). Idiopathic generalized epilepsies made 13,3% with predominance of child absence epilepsies — 39,8%. Epileptic encephalopathy made 3,46% with predominance of West syndrome — 64,3%. In treatment monotherapy were used in 75% of cases, the polytherapy took 25%.

The 81 patients suffering from chronic arterial insufficiency of lower extremities (LE) dueto obliterating atherosclerosis (OA) underwent surgical sympathectomy at L₂ , L ₃, L₄ lumbar level on the side of lesion. Radiofrequency thermodestruction (RF) was used in 60 patients, open sympathectomy was perfomed in 21 patiens. Pain relief was achieved in all patients. Dopplerography data demonsrated the improvement of blood flow in LE. This study had showed high efficiency of RF in treatment of patients with OA.

This procedure is less traumatic than open сympathectomy.

The new method of cerebral vasospasm management is proposed. Selective radiofrequency thermodestruction of the cervical sympatethic ganglion at the С₆ , С₇ on the side of vasospasm has been performed. This study showed high efficiency for treatment of patients with cerebral vasospasm due to aneurysm rupture.

The problem of pathogenesis of multiple sclerosis is of great importance in modern neurology and its solution allows to determine a pathogenetic approach to treatment of this severe disease. Complex clinical-biochemical investigation has been conducted in 79 patients with multiple sclerosis and 75 mentally and physically healthy persons. Parameters of intensification of lipid peroxidation and indices of the state of enzymatic and non-enzymatic patterns in antioxidant defense system in different clinical forms and at different stages of MS course have been analyzed. The data obtained confirm the presence of oxidant stress in the development of pathological process in MS.

The purpose of the study was to study cognitive disorders in the patients with traumatic intracranial hematomas after the operation. 150 operated patients were neuropsychologically assessed with qualitative and quantitative analysis. Differently expressed cognitive disorders were revealed in the most of (95%) patients. The patients with hematomas combined with cerebral foci of crushing had more severe cognitive deficit than the patients with ‘isolated’ hematomas. Localization of cerebral lesions had the principal effect on the features and expressiveness of cognitive impairment in the patients with hematomas combined with foci of crushing. The duration of the interval from the moment of trauma till operation had the most significant influence on the severity and the features of cognitive disorders in patients with isolated hematomas. The restoration of cognitive functions depended on severity of cognitive disorders in acute stage.

Revealing the particularities of the ischemic stroke course in patients with different types of cardiac pathology, with disturbances of the rhythm first of all, can play the certain role in forecast and tactic of the treatment of this disease. Analysis of the clinical particularities of the cardioembolic stroke course, depending on infarction localizations and type accompanying heart pathology was made. Examination of 61 patients, with determination degree of stroke gravity using American Scale (NIH-NINDS) on 1-st, 3-d and 10-th day of the disease was performed. The positive correlation was revealed between patients age and cardioembolic stroke frequency, cardiac rhythm disturbances and primary localization of the ischemia in pool of the left middle cerebral artery. The permanent form of the precordial twinkling is the most disadvantage prognosis factor and associated with forming the more severe neurological deficit.

Neurological, psychological, anthropological, biochemical, and neurovisualization statuses have been studied in 45 female patients after ischemic stroke and 40 women with chronic cerebrovascular pathology. Significant differences are demonstrated in the group of ischemic stroke patients toward more serious dishormonal disorders compared to the group of patients with moderate discirculator encephalopathy.

It appears that sometimes it is difficult to perform differential diagnostics of multiple sclerosis and autoimmune illness. 29 patients were surveyed with lupus erythematosus and 29 patients hue suffer from multiple sclerosis. Here are presented our own results of magnetic resonance imaging of the brain of there patients. It is discovered that existence of nidus of T2 signal increase doesn’t appear to be a specific sign.

283 patients with gliomas were included in this study. Age, sex, neurological status and Karnovsky performance were analyzed before and after surgery, also tumor location, type and volume of surgical resection, postoperative complications were considered. Volume of tumor resection did not depend on glioma localization, excluding deep located tumors, in which case stereotactic cryotomy was performed (p < 0,01). In cases of stereotactic cryotomy postoperative neurological deficit worsening was noted in 12,5%, in patients with open biopsy and partial resection — 10,9%, and in case of total or subtotal tumor resection in 7,0% (p > 0,05). Partial gliom resection often related with postoperative complications and neurological deficit worsening then open surgery total tumour resection. Stereotactic cryotomy does not lead to bigger postoperative complications frequency in comparisons with open surgery.

Extracerebral tumors of posterior fossa often lead to dysfunction of the brain stem, however the degree of brain stem’s damage is determined most often on the basis clinical data only. Magnetic Resonance Spectroscopy (MRS) allows to study biochemical processes and determine chemical content of the cerebral tissues noninvasively. Changes in brain stem’s perifocal zone in patients with acoustic neuromas and subtentorial meningiomas have been studied. Basic metabolite’s level’s analysis of N-acetyl-asparatate (NAA), creatine, choline and lactate have been conducted. Changes in brain stem’s metabolism depend on duration of the disease and the conditions of the patient on admission have been revealed. However the change in metabolite’s level and their role in the brain in case of pathology and in normal conditions need further investigations.

The purpose of present research is to estimate the correlation between vegetative dysfunction and cognitive impairment in patients with chronic ischemia of the brain. We supervised 112 patients with chronic ischemia of the brain. To determine cognitive impairment we used Mini Mental State Examination scale. To determine vegetative dysfunction we used A.M.Vayne's questionnaire. Also heart rate variability (HRV) examination was carried out. All the patients were divided into 2 groups depending on expressiveness of cognitive impairment: light and moderate cognitive impairment. The expressed vegetative dysfunction was revealed according to A.M.Vejna's questionnaire and according to HRV in patients with moderate cognitive impairment. In patients with chronic ischemia of the brain with moderate cognitive impairment revealed shift of vegetative balance aside prevalence of hyperactivity of sympathetic adrenal system that is adverse the factor in progressing a chronic ischemia of a brain.

The people epylepsy-suffering were divided into native people and non-native people in the researched population. Among epileptics the percentage of tyvans was 75,47%, from which the percentage of men was 56,09% and the percentage of women was 43,91%. General spread of epilepsy among native people was 2,54 ± 0,28 in the researched population which corresponds to the level of spread of epilepsy in the population without taking in the account ethnic characteristic. The measures of average debut of epilepsy, average age on the moment of research, average duration of epilepsy among tyvans, didn’t differ from measures of non-native people. The ethiological spectre of epilepsy among natives and non-natives corresponded to the one in the rest og regions of Russia and world. The more favourable course of epilepsy differs the natives from others on the frequency of epilepsy-attacks among revealed epileptics.

Multiple sclerosis (MS) — autoimmune disease of CNS, characterized by myelin destruction and axonal damage. To study cognitive functions, the authors used the Mini-Mental State Examination (MMSE), the frontal assessment battery, the procedure developed by A.R. Luriya, neurophysiological characteristics. 71 patients were underwent magnetic resonance imaging. The aim of the study was to analyse the parameters of neuropsychological method, cognitive evoked potentials P300 and the role of brain atrophy in MS. The cognitive functions, the activity of the disease and the expression of brain atrophy are bound by the certain way.

The article is devoted to specify the main prognostic factors influencing quality of a life of patients with а heavy head injury. The role and value of clinical manifestations of the hypertension-dislocation syndrome and the subarachnoid hemorrhage are considered in prognosis of outcomes of treatment of the patients with a heavy head.

A comparative clinical and serological analysis of two groups compatible by sex, age and clinical forms of acute tick-born encephalitis was conducted among 68 patients with confirmed immune enzyme method. All patients received a single injection of high titrating Russian human tick-borne encephalitis immunoglobulin by the doze varying on the patient’s weight and particular decease. All patients received symptomatic therapy as well. There were 33 patients in the group II who have been taking anaferon during two weeks since the acute period. The patients of the groups I and II didn’t have any robust alteration of the feverish period duration and cerebrospinal fluid sanitation but it was discovered that the patients of the group II with focal form had reveal predominance of IgM titer on the second week of the disease development comparing with the same indicators among the patients of the group I with focal form. The findings show the possibility to recommend anaferon for complex treatment of the patients with tick-born encephalitis in acute period.

The aim of this investigation is to study the effect of BTA on the cerebral blood flow in patients with chronic daily headache. The analysis of Doppler ultrasonography and transcranial Dopplergraphy findings has shown the following: after the treatment 34% of the patients had no extravasal effect and in 66% of the patients it became moderate and after the treatment normal venous outflow was found in 58% of the patients . The results of the pilot study demonstrate the effect of BT-A injection on the cerebral blood flow by means of optimizing both the arterial blood flow and the venous outflow from the cavity of the skull.

With the purpose of clinical determinants definition of neurological deterioration in patients with an ischemic stroke and its prognostic value, the retrospective analysis of case records of 253 patients with first in a life stroke was carried out and the estimation of neurological deterioration of early period of an stroke was performed.

Basal-cellular skin cancer takes the first place accounting for 75—95% of malignant skin tumors. Despite different methods of treatment recurrence rate is up to 39%. Recurrent forms may invade soft tissues, major vessels, nerves and bones of the skull base. Options of surgical treatment of wide-spread recurrent forms are considered in this article. Modified block-resection of parotid-masticatory region along with temporal pyramid invasion is presented. Short- and long-term follow-up results are also presented.

Studied clinical aspects of a current of a sharp stage tick-borne borreliosis against opisthorchosis. On the basis of the conducted research an adverse current sharp tick-borne borreliosis, which is characterizing lengthening of the incubatory period, an encephalopathy with proof vegetative infringements and a long asthenic syndrome was established. All it as a whole leads to increase in duration of the period rehabilitations.

Because of the long usage of obsidane the cerebrum liquid’s flow-out to the one of the brain hemisphere breaks and also local edema of the brain en-larges.

Brain-steam acoustic evoked potentials (BAEP) study was carried out in 84 patients with chronic-pain syndrome due to trigeminal neuralgia (TN). Preoperative BAEP changes were detected in all patients with TN. There were no specific differences in BAEP among variants of the disease course preoperatively. Percutaneous radiofrequency termocoagulation of Gasserian ganglion could be explored in all etiological types of TN. The lesion in trigeminal ganglion raised functional activity in the brain-stem part of the antinociceptive system. The radiofrequency lesion blocked the afferent pulsation from a peripheral part. It both relieved the severe pain and restored the damaged sanogenetic mechanism of pain suppression. Unrestorable BAEPs postoperatively were a prognostic factor for the pain relapse in patients with TN.