In the work the author’s private material devoted to the 40 years experience of the surgical treatment of liver focal affections is analyzed. The methods and the technology of the surgery intervention are discussed and the new methodic of liver resection which was suggested by the author of the work is demonstrated. There is the information about the operative interventions that were for the first time suggested and realized by the author in the cases of the focal affections of liver.
The outcomes and far results of the surgical treatment are analyzed. Also there is the information about the benefit to use the new technologies doing the interventions in the cases of focal affections of liver.

This paper presents the results of comparative study of the therapeutic activity, mechanism of action and combined use of original natural hepatoprotective agents eplir, lochein, macsar, essentiale, and legalon in experimental toxic hepatitis and Reye`s syndrome model.

A complex research of the structural-metabolic features and the functional status of erythrocytes in peripheric blood of people with mental disorder and somatic pathology was carried out. It was revealed that when having schizophrenia, exogenous mental deficiency, neurotic disorder, Alzheimer's disease, malignant neoplasm of different localization, chronicle nonspecific diseases, acute pneumonia, atherosclerotic affection of limbs’ arteries, heat injury there are evident abnormalities of albuminous and lipid composition of membrane of erythrocytes, change of microviscosic features of lipid phase and disorder of cationtransporting membrane system, disorganization of superficial architectonics and ultrastructure of red blood cells, their deformation and aggregative features. The discovery of nonspecific character of structural-functional disorders of erythrocytes in the pathological processes and conditions allows to suggest that there is typical reaction of peripheric link of erythrone.

In this study the features of developing cancer both in the left and right breast have been compared. We examined 45 parameters which characterize clinical as dell as morphological features of breast cancer. Of all parameters investigated only 5 are more informative ones. They show that breast cancer is developing differently in the right and the left breast. We conclude that localization of cancer in the right breast has a worse prognosis. The results obtained are discussed.

With the purpose of research of clinical efficiency of trimetazidine and atenolol and their influence on morfofunctional parameteres of left ventricle 36 men who have transferred a myocardial infarction are inspected. Patients were randomly divided into 2 groups. Clinical status and function state of left ventricle (by echocardiography) was assessed before and after 4-week therapy with trimetazidine or atenolol. Atenolol and trimetazidine have shown in our study identical clinical efficiency. However while atenolol is statistically significant reduced systolic arterial pressure and heart rate, thickness of posterior wall of left ventricle and corrects diastolic function, trimetazidine had no such activity. Treatment with trimetazidine promoted improvement of local contractility of left ventricle.

The research is devoted to the evaluation of the depressor and constrictive components of the vascular reactiveness in the people with burdened heredity on atherosclerosis and the factors of risk of this disease’s development. The connection of the vascular reactiveness of peripheral arteries with the factors of risk of atherosclerosis development is discovered. The results of researches allow to suppose that atherogenic factions of lipoproteins, inflammatory cytokines produced by mononuclear of nitric oxide participate in the formation of pathological vascular reactions in people with atherosclerosis and with burdened atherosclerosis heredity on preclinical disease level.

In clause the approaches to development of complex system of motivation of the participants of system of organization of the medicinal help are submitted which is directed first, on reduction of losses of a community caused by blocking of economic potential of the man at disease or death, secondly, of an expense for restoration of economic potential of the man should be economically expedient.

In a prospective study the group of 60 women with AIT and thyroidological uneventful control women, matched for age and parity (n = 30) were tested at 12 and 32 weeks gestation for percentages of peripheral blood lymphocyte subsets (CD3, CD4, CD8, CD16, HLA-DR major histocompatibility complex (MHC)-class II), IL-2, IFN-gamma, TPO-Abs, TSH and thyroxin.
Twenty five pregnant women with AIT (41,7%) developed preeclampsia (against 16,7% in control). Pregnancyrelated CMI alterations consisted of low percentages of CD16⁺ NK cells and all subpopulations of T-cells at 12 weeks gestation. The development of preeclampsia in women with AIT was accompanied with increasing percentage of HLADR⁺ T- lymphocytes. The high levels of TPO-Abs and activated T-lymphocytes in pregnant women with autoimmune thyroiditis has been suggested as a predictor for later preeclampsia development.

In this article it is overviewed some literature connected with the discovery and scientific description of the trematode Opisthorchis felineus more than a hundred years ago. Special attention has been paid to the relationship between opisthorchiasis and cholangiocarcinoma development in humans. Some data from research literature and the author's own publications illustrated various cytogenetic aberrations in peripheral blood lymphocytes of opisthorchiasis patients have been cited in this article. Such chromosome aberrations were detected more frequently among the new arrivals than the local inhabitants. Many of the chromosome breaks are located near to some cellular oncogenes of the human chromosomes. Superactive biotransformation of some xenobiotics into mutagenic and carcinogenic agents was found in the liver of opisthorchiasis patients. The facts about the distribution of Opisthorchis felineus in Russia are also cited.

Complex interactions between nitric oxide and cytokines of atopic inflammation are presented. The effects of interleukin-4 on nitric oxide synthesis, immunoregulatory properties of nitric oxide and its influence on Th1/Th2 balance are described.

The process of formation of a single government politics in the sphere of industrial property is discussed. It is pointed out that economical significance of the objects of IP is rising because of priority orientation of the Russian science and industry on making scientific, good production. The questions of effective legal protection and commerce realization of the IP objects are also touched. It is settled that support and development of the patent service in the institutions of higher education are necessary.

In the article the modern situation of the post degree courses of the medical workers in the Siberian State Medical University are presented, also the problems of the post degree medical education and the achievements of SSMU in this sphere of this activity are considered and pointed out.

The questions of industrial property commercialization in the sphere of medicine are discussed. The reasons according to which the patenting of inventions in the sphere of medicine occurs with legal and financial difficulties are pointed out. The author of the article proposes several ways to overcome difficulties appearing when new preparations, equipment and the methods of treatment are inserted.

The modern view on the problem of the disorder of stomach is presented that is very important for working out the treatment for this category of ill people.

It is proved that intrauterine infections influence negatively on the period of pregnancy, the condition of fetus and newborn on the example of isolated, chlamydeous and chlamydeous-virus infections. The schemes of treatment of pregnant women in these groups are determined. It is revealed that the percentage of the possibility and the degree of heaviness of intrauterine infection is lowing if the newborn were born by women who got the treatment in the period of pregnancy.

On the basis of diagnostics of 100 patients, 25 doctors of Saratov and 72 histories of illness of the patients with severe acute asthma in four different hospitals there were presented the results that prove the great amount of defections in diagnostics quality, conducting and treatment of patients at various stages of rendering of medical aid.
There were defined the difficulties of diagnostics and the main factor of severe current of asthma and death.
The difficulties are both in absence of primary training of the patients, and in absence of constant, regular supervision of these patients by the local doctor. It is connected not only with the absence of time on doctor’s dialogue with the patient, but also with ignorance and frequently unwillingness of the doctor to learn the modern approaches of conducting and treatment of asthma. The received data confirms that the major factors conducting to increase of severe current of asthma and the increase of mortality are bad diagnostics, inadequate conducting and treatment, and the education of the patients is very necessary part of the general common program of asthma treatment.

On the basis of the analysis of cases 713 patients were revealed postoperative complications because of shortcoming of drainage of pancreas area at surgical treatment of different pancreas diseases. Тhe new method drainage of pancreas area in clinic was elaborated for liquidation of shortcoming offered before methods drainage.

For the first time in the rhinological practice the methods of evaluation of the functional state of tissues of nasal cavity that were based on registration of their electrical features-electrical resistance (impedance) and potencial were worked out. In the comparative aspect there were researched the active and the passive electrical features of the tissues of nasal cavity which healthy people and those whose disease is acute sinusitis, have. For the first time the dynamic of electrical features was studied and the most informative electrical rates for the initial diagnostic of acute sinusitis and for evaluation of the effectiveness of appointed treatment were revealed.
As a result of researches a new way of noninvasive diagnostic of inflammatory diseases of paranasal sinus was worked out, approved and inserted in practice. (Patent № 2157094, 10.10.2000 «The way of diagnostic of inflammatory diseases of paranasal sinus»). The suggested way is simple, reliable; it has high credibility value of revealing the pathologies of paranasal sinus and evaluation of its dynamic. This method may be recommended for the wide usage in hospitals and clinics for diagnostic of acute sinusitis and evaluation of effectiveness of treatment.

There was worked out a new method of plastics of chest wall defects by means of construction from nikelide of titan. An experimental examination of effectiveness of the method with the use of clinical, roentgenological and morphologic control was carried out. The method provides normalization of biomechanics of respiration by means of restoration of osteochondrous skeleton and liquidation of cosmetic defection.

In the article the view of the scientific researches of the Department of radial diagnostic in SSMU is presented. Within the frames of the department interests besides the traditional researches in the fields of roentgenology there are such modern methods of medical visualization as search of new methods of osteoporosis-very developed and socially significant disease. The possibilities of usage the ultrasound for revealing the acute surgeon pathology of stomach and also for determination of criterias of activity of rheumatoid arthritis in knee-joint are studied. The new radioisotope methods of visualization of inflammatory processes of different localization are worked out. The possibilities of HRCT in the diagnostic of chronical obstructive diseases of lungs and obstructive bronchitis (COB) and bronchial asthma (BA) are researched.
The intrusion of radial diagnostic methods for the determination of toxic influence of hepatite and drugs on the condition of parenchymatous organs existing in people who are drug addicts appears to be a new direction in work of the Department.

By immune-enzyme analysis the content of oncomarkers in serum of blood that exist in people living in the territories of the Tomsk region with bad ecological situation was researched. It was established that practically all people living in the polluted territories have deflections from normal conditions of oncomarkers, but in the control-less than 70%. The deflections on 2 or more oncomarkers in control exist in less than 10% researched people, and in the researched regions-more than 40%.

The analytical potentialities of computer dactyloscopic program «Cyberinform» (SSMU, Tomsk) were described. It can be used as an addition to the programs, performing the automatic recognition of the principle dermatoglyphics signs of fingers. One of the main advantages of the mentioned program is an ability to analyze excerpts out of thousands of dactylocards and to compare them between one another, this was demonstrated on the example of Russians and Koreans living in Siberia. The program may be useful to various medico-genetic and anthropo-genetic scientific studies, which up to now were performed by routine methods and took a long time.

In the article the creative biography of Dmitruk S.E., the dean of pharmaceutical department of the Siberian State Medical University is introduced.