АNTIARRHYTHMIC ACTIVITY OF DIBORNOL IN THE MODEL OF АСUTE MYOCARDIAL ISCHEMIA/REPERFUSION
https://doi.org/10.20538/1682-0363-2013-3-153-156
Abstract
We studied the аntiarrhythmic activity of novel sterically hindered phenols – 4-methyl-2,6diisobornilphenol (dibornol) in acute myocardial ischemia/reperfusion in male Wistar rats. Left coronary artery occlusion (10 min) in control group induced different ventricular arrhythmia and 23% mortality of animals. Dibornol (p.o. administration 100 mg/kg 24 and 3 hours before ischemia) did not change frequency and kinds of arrhythmia in acute ischemia, but significantly reduced the frequency and serious of arrhythmia in the reperfusion period, decreased the mortality of rats due to lethal arrhythmia.
About the Author
P. P. Shchetinin
Siberian State Medical University, Tomsk
Russian Federation
Shchetinin Poytr P.
Russian Federation
Shchetinin Poytr P.
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Review
For citations:
Shchetinin P.P. АNTIARRHYTHMIC ACTIVITY OF DIBORNOL IN THE MODEL OF АСUTE MYOCARDIAL ISCHEMIA/REPERFUSION. Bulletin of Siberian Medicine. 2013;12(3):153-156. (In Russ.) https://doi.org/10.20538/1682-0363-2013-3-153-156
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