Wound-healing effect of substances based on lanolin and Ganoderma applanatum and Fomitopsis pinicola (xylotrophic basidiomycetes) extracts

Aim. To evaluate the wound-healing effect of substances based on lanolin and Ganoderma applanatum and Fomitopsis pinicola extracts.

Materials and Methods. The experiment used 20 white laboratory rats. The study included 3rd-degree burn modeling with wound exposure to an ointment containing Ganoderma applanatum and Fomitopsis pinicola extracts. A morphological investigation of skin was carried out with an assessment of the following parameters: epidermis thickness, fibroblast count, number of blood vessels, vessel area, and number of vessels with erythrocyte stasis, leukocyte stasis, and leukocyte diapedesis.

Results. Ganoderma applanatum and Fomitopsis pinicola extracts intensified regenerative processes. By day 14 of the experiment, epithelialization of the defect and scar formation took place. Application of the extract-containing ointments reduced exudation, microcirculatory disorders, and inflammatory infiltration.

Conclusion. The results suggested the beneficial effect of the Ganoderma applanatum and Fomitopsis pinicola extracts on the wound-healing process and demonstrated their potential for skin regeneration.

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