The role of vitamin D in immunoadjuvant therapy for tuberculosis depending on the HIV status of patients
https://doi.org/10.20538/1682-0363-2025-3-163-171
Abstract
Search queries were conducted in the PubMed and eLIBRARY.ru databases using keywords, including publications from 2018–2024. A review of the literature on vitamin D deficiency in patients with tuberculosis (TB), human immunodeficiency virus (HIV), and TB/HIV combination is presented, which revealed heterogeneous prevalence. The roles of vitamin D in the body immune response to TB are shown depending on the presence of HIV infection. The data on the therapeutic use of single and prolonged administration of vitamin D at various doses in adjuvant TB therapy are presented. The prospects for the use of vitamin D in the combined treatment of TB patients are outlined depending on the HIV status, especially with multidrug-resistant pathogens requiring study in Russian clinical trials.
Supporting agencies: The authors state that they received no funding for the study
About the Authors
O. V. Filinyuk
Siberian State Medical University
Russian Federation
Competing Interests:
Russian Federation
2 Moskovsky trakt, 634050 Tomsk
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest related to the publication of this article
V. V. Khokhlyuk
Siberian State Medical University
Russian Federation
Competing Interests:
Russian Federation
2 Moskovsky trakt, 634050 Tomsk
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest related to the publication of this article
A. O. Volkovskaya
Siberian State Medical University
Russian Federation
Competing Interests:
Russian Federation
2 Moskovsky trakt, 634050 Tomsk
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest related to the publication of this article
References
1. Стародубов В.И., Цыбикова Э.Б., Котловский М.Ю., Лапшина И.С. Заболеваемость туберкулезом в России в период до и во время пандемии COVID-19. Инфекционные болезни: новости, мнения, обучение. 2023;12(3):18–25. DOI: 10.33029/2305-3496-2023-12-3-18-25.
2. Ставицкая Н.В., Фелькер И.Г., Немкова Е.К. Диагностика лекарственной устойчивости M. tuberculosis в регионах Сибирского федерального округа. Туберкулез и болезни легких. 2024;102(3):48–57. DOI: 10.58838/2075-1230-2024102-3-48-57.
3. Ставицкая Н.В., Немкова Е.К., Ташкова Г.В. Основные показатели противотуберкулезной деятельности в Сибирском и Дальневосточном федеральном округе (статистические материалы). Новосибирск, 2024:158. https://cloud.mail.ru/public/nKcw/UEEQ7GSeo.
4. Mi J., Wu X., Liang J. The advances in adjuvant therapy for tuberculosis with immunoregulatory compounds. Front. Microbiol. 2024;15. DOI: 10.3389/fmicb.2024.1380848.
5. Можокина Г.Н., Самойлова А.Г., Абрамченко А.В., Романова М.И., Васильева И.А. Стратегия «терапии хозяина» при туберкулезе. Значение интерферона-гамма в патогенезе и терапии туберкулезной инфекции. Туберкулез и болезни легких. 2024;102(1):72–81. DOI: 10.58838/2075-12302024-102-1-72-81.
6. Ismailova A., White J.H. Vitamin D, infections and immunity. Rev. Endocr. Metab. Disord. 2022;23:265–277. DOI: 10.1007/s11154-021-09679-5.
7. Bikle D.D. Vitamin D Regulation of Immune Function. Curr. Osteoporos Rep. 2022;20(3):186–193. DOI: 10.1007/s11914022-00732-z.
8. Лавряшина М.Б., Имекина Д.О., Тхоренко Б.А., Ульянова М.В., Мейер А.В., Тарасова О.Л. и др. Сигнальный каскад системы витамина D в макрофагах против Mycobacterium tuberculosis. Инфекция и иммунитет. 2023;13(2):234–242. DOI: 10.15789/2220-7619-VDS-2033.
9. Papagni R., Pellegrino C., Di Gennaro F., Patti G., Ricciardi A., Novara R. et al. Impact of vitamin D in prophylaxis and treatment in tuberculosis patients. Int. J. Mol. Sci. 2022;23(7). DOI: 10.3390/ijms23073860.
10. Junaid K., Rehman A. Impact of vitamin D on infectious disease-tuberculosis-a review. Clinical Nutrition Experimental. 2019;25:1–10. DOI: 10.1016/j.yclnex.2019.02.003.
11. Ayelign B., Workneh M., Molla M.D., Dessie G. Role of vitamin-D supplementation in TB/HIV co-infected patients. Infect. Drug Resist. 2020; 13:111–118. DOI: 10.2147/IDR.S228336.
12. Сoussens A., Timms P.M., Boucher B.J., Boucher B.J., Venton T.R., Ashcroft A.T. et al. 1alpha,25-dihydroxyvitamin D3 inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infection. Immunology. 2009;127(4):539–548. DOI: 10.1111/j.1365-2567.
13. Aibana O., Huang C.-C., Aboud S., Arnedo-Pena A., Becerra M.C., Bellido-Blasco J.B. et al. Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis. PLoS Med. 2019;16(9):1002907. DOI: 10.1371/journal.pmed.1002907.
14. Zhou Y., Wu Q., Wang F., Chen S., Zhang Y., Wang W. et al. Association of variant vitamin statuses and tuberculosis development: a systematic review and meta-analysis. Ann. Med. 2024;56(1). DOI: 10.1080/07853890.2024.2396566.kafle.
15. Kafle S., Basnet A.K., Karki K., Thapa Magar M., Shrestha S., Yadav R.S. Association of Vitamin D Deficiency with Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis. Cureus. 2021;13(9):e17883. DOI: 10.7759/cureus.17883.
16. Mamadapur V.K., Nagaraju S., Prabhu M.M. Comparative study of vitamin D levels in newly diagnosed tuberculosis and a normal population. Medicina. 2024;60(5):685. DOI: 10.3390/medicina60050685.
17. Chesdachai S., Zughaier S.M., Hao L., Kempker R.R., Blumberg H.M., Ziegler T.R. et al. The effects of first-line anti-tuberculosis drugs on the actions of vitamin D in human macrophages. J. Clin. Transl. Endocrinol. 2016;6:23–29. DOI: 10.1016/j.jcte.2016.08.005.
18. Allavena C., Delpierre C., Cuzin L., Rey D., Viget N., Bernard J. et al. High frequency of vitamin D deficiency in HIV-infected patients: effects of HIV-related factors and antiretroviral drugs. Journal of Antimicrobial Chemotherapy. 2012;67(9):2222–2230. DOI: 10.1093/jac/dks176.
19. McCartney C.R., McDonnell M.E., Corrigan M.D., Lash R.W. Vitamin D Insufficiency and Epistemic Humility: An Endocrine Society Guideline Communication. J. Clin. Endocrinol. Metab. 2024;109(8):1948–1954. DOI: 10.1210/clinem/dgae322.
20. Панова Л.В., Авербах М.М., Овсянкина Е.С., Захарова И.Н., Карасев А.В., Хохлова Ю.Ю. и др. Статус витамина D и уровень β1и β2-дефензинов у детей и подростков с различными формами туберкулеза органов дыхания. Медицинский совет. 2024;18(1):90–96. DOI: 10.21518/ms2024-006.
21. Яровая Ю.А., Лозовская М.Э., Крылова С.А., Гурина О.П., Блинов А.Е., Шибакова Н.Д. Обеспеченность витамином D детей с латентной туберкулезной инфекцией и пациентов с туберкулезом. Медицинский совет. 2024;(19):214–222. DOI: 10.21518/ms2024-393.
22. Zafar S., Siddiqui Z., Agrawal N., Madhurmay Singh M. A Comparative Analysis of Vitamin D Status among Tuberculosis Patients and Healthy Household Contacts: A Case–Control Study from Central India. Apollo Medicine. 2024;21(4):308–313. DOI: 10.1177/09760016241245580.
23. Eletreby R., Elsharkawy A., Mohamed R., Hamed M., Kamal Ibrahim E., Fouad R. Prevalence of vitamin D deficiency and the effect of vitamin D3 supplementation on response to anti-tuberculosis therapy in patients with extrapulmonary tuberculosis. BMC Infect. Dis. 2024;24(1):681. DOI: 10.1186/s12879-024-09367-0.
24. Acen E.L., Biraro I.A., Bbuye M., Kateete D.P., Joloba M.L., Worodria W. Hypovitaminosis D among newly diagnosed pulmonary TB patients and their household contacts in Uganda. Sci. Rep. 2022;12(1):5296. DOI: 10.1038/s41598-022-09375-7.
25. Jaimni V., Shasty B.A., Madhyastha S.P., Shetty G.V., Acharya R.V., Bekur R. et al. Association of vitamin D deficiency and newly diagnosed pulmonary tuberculosis. Pulm. Med. 2021; 2021:5285841. DOI: 10.1155/2021/5285841.
26. Maceda E.B., Gonçalves C.C.M., Andrews J.R., Andrews J.R., Ko A.I., Yeckel C.W. et al. Serum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners. Sci. Rep. 2018;8(1):997. DOI: 10.1038/s41598-018-19589-3.
27. Nielsen N.O., Skifte T., Andersson M., Wohlfahrt J., Soborg B., Koch A. et al. Both high and low serum vitamin D concentrations are associated with tuberculosis: a case – control study in Greenland. British Journal of Nutrition. 2010;104(10):1487–1491. DOI: 10.1017/S0007114510002333.
28. Rathored J., Sharma S.K., Chauhan A., Singh B., Banavaliker J.N., Sreenivas V. et al. Low serum vitamin D in North Indian multi-drug-resistant pulmonary tuberculosis patients: the role of diet and sunlight. Ann. Med. 2023;55(2):2291554. DOI: 10.1080/07853890.2023.2291554.
29. Wang Y., Huang X., Wu Y., Li A., Tian Y., Ren M. et al. Risk of Vitamin D Deficiency Among HIV-Infected Individuals: A Systematic Review and Meta-Analysis. Front. Nutr. 2021;8: 722032. DOI: 10.3389/fnut.2021.722032.
30. Xie K., Zhang Y., Zhang M., Wu H., Zheng L., Ji J. et al. Association of vitamin D with HIV infected individuals, TB infected individuals, and HIV-TB co-infected individuals: a systematic review and meta-analysis. Front. Public Health. 2024;12:1344024. DOI: 10.3389/fpubh.2024.1344024.
31. Salahuddin N., Ali F., Hasan Z., Rao N., Aqeel M., Mahmood F. Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis. BMC Infect. Dis. 2013;13:22. DOI: 10.1186/1471-2334-13-22.
32. Martineau A.R., Timms P.M., Bothamley G.H., Hanifa Y., Islam K., Claxton A.P. et al. High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet. 2011;377(9761):242–250. DOI: 10.1016/S0140-6736(10)61889-2.
33. Tamara L., Kartasasmita C.B., Alam A., Gurnida D.A. Effects of Vitamin D supplementation on resolution of fever and cough in children with pulmonary tuberculosis: A randomized double-blind controlled trial in Indonesia. J. Glob. Health. 2022;12:04015. DOI: 10.7189/jogh.12.04015.
34. Wen Y., Li L., Deng Z. Calcitriol supplementation accelerates the recovery of patients with tuberculosis who have vitamin D deficiency: a randomized, single-blind, controlled clinicaltrial. BMC Infect. Dis. 2022;22(1):436. DOI: 10.1186/s12879-022-07427-x.
35. Hassanein E.G., Mohamed E.E., Baess A.I., El-Sayed E.T., Yossef A.M. The role of supplementary vitamin D in treatment course of pulmonary tuberculosis. Egypt. J. Chest. Dis. Tuberculosis. 2016;65(3):629–635. DOI: 10.1016/j.ejcdt.2016.03.004.
36. Kota S.K., Jammula S., Tripathy P.R., Panda S., Modi K.D. Effect of vitamin D supplementation in type 2 diabetes patients with pulmonary tuberculosis. Diabetes metabolic syndrome. Clin. Res. Reviews. 2011;5(2):85–89. DOI: 10.1016/j.dsx.2012.02.021.
37. Eletreby R., Elsharkawy A., Mohamed R. Prevalence of vitamin D deficiency and the effect of vitamin D3 supplementation on response to anti-tuberculosis therapy in patients with extrapulmonary tuberculosis. BMC Infect. Dis. 2024;681. DOI: 10.1186/s12879-024-09367-0.
38. Sudfeld C.R., Mugusi F., Muhihi A., Aboud S., Nagu T.J., Ulenga N. et al. Efficacy of vitamin D (3) supplementation for the prevention of pulmonary tuberculosis and mortality in HIV: a randomised, double-blind, placebo-controlled trial. The lancet HIV. 2020;7(7):463–471. DOI: 10.1016/S2352-3018(20)30108-9
39. Cai L., Wang G., Zhang P., Hu X., Zhang H., Wang F. et al. The progress of the prevention and treatment of vitamin D to tuberculosis. Front. Nutr. 2022;9:873890. DOI: 10.3389/fnut.2022.873890.
40. Sun Q., Li S., Gao M., Pang Y. Therapeutic strategies for tuberculosis: progress and lessons learned. Biomedical and Environmental Sciences. 2024;37(11):1310–1323. DOI: 10.3967/bes2024.168
Review
For citations:
Filinyuk O.V., Khokhlyuk V.V., Volkovskaya A.O. The role of vitamin D in immunoadjuvant therapy for tuberculosis depending on the HIV status of patients. Bulletin of Siberian Medicine. 2025;24(3):163-171. https://doi.org/10.20538/1682-0363-2025-3-163-171
Views:
309
JATS XML
Email this article 