The study evaluated the rheological parameters of blood: blood viscosity, plasma viscosity, hematocrit, red blood cell aggregation and deformability. The severity of the patients was assessed by clinical scales:Glasgowcoma scale, the scale NIHSS, Barthel index. The study found that in the acute phase of ischemic stroke increased blood viscosity by increasing red blood cell aggregation and reduced erythrocyte deformability. The increase in the viscosity of the blood in acute ischemic stroke is accompanied by increased severity of neurological disorders.

The study involved 280 patients aged 10 to 70 years old with a valid diagnosis of multiple sclerosis according to the McDonald criteria. There  are 6 (2.1%) patients had the first manifestation of disease overthe age of 45, 18 (6.4%) – 20 years earlier. In 7 (2.5%) of patients diagnosed with malignant progressof the MS, in 30 (10.7%) – soft progress.

The acoustic deckman and somatosensorny caused potentials at 65 patients with the complicated trauma of cervical department of a backbone are investigated. It is established that the complicated trauma of cervical department of a backbone leads to functional violations at level of cervical segments of a spinal cord and deckman structures of a brain. Existence of functional changes is influenced by weight of damage of a spinal cord and degree of instability of vertebras.

We investigated the predictors of increased seizures’ frequency among women with various forms of idiopathic generalized epilepsies (IGE) in the gestational and postgravid period. We observed 41 patients with Idiopathic generalized epilepsy (IGE) before, during and after pregnancy. During the period of observation EEG was recorded in the states of relaxed and active awakeness and sleeping. Patients, who have stopped to take anticonvulsants before pregnancy, have had increased frequency of seizures, more than1 ina year, with interictal epileptiform discharges in a state of relaxed and active awakeness. Increased seizures after pregnancy was observed in patients with interictal epileptiform discharges during sleep. The results can be used during the preparation of pregravid women with IGE. 

Objective: a comparative analysis of risk factors for stroke in patients with stroke, depending on sex, analysis of the frequency of occurrence of risk factors in patients and healthy people Tuvan nationality. Materials and methods. A case-control study of major risk factors for ischemic stroke (hypertension, family history, cardiac pathology, diabetes, etc.) in the two groups. Results. The first place is in the frequency of hypertension, family history and then, at the last-myocardial infarction. Conclusions. Among the population of Tuva has been a clear upward trend in ischemic stroke associated primarily with a high prevalence of hypertension, inadequacy of its treatment, as well as alcohol abuse. 

Clinical electrophysiological and immunological studies of 88 cancer patients showed that in breast cancer and small lung cancer takes place symmetric, distal, sensory-motor, axonal-demyelinating polyneuropathy. Autoimmune nature of the disease confirmed onconeural antigens detected in the serum of more than half of the study participants. 

Are defined frequency of mild cognitive impairment (MCI) at patients of advanced and senile age with chronic ischemia of a brain (HIGM) in comparison with frequency of existence of a depression, an education level and the place of residence and their interrelation. 100 patients with HIGM 2 age групп: 1 – advanced age (from 60 to 74 years – 48 people), 2 – senile age (from 75 to 89 years – 52 persons) are surveyed. In research didn't join: patients with Alzheimer's disease and other forms of a dementias. Diagnostics of UKN it was carried out by means of a short scale of an assessment of the mental status (MMSE). For an assessment of existence of a depression – Bek's scale. For objective justification of conclusions from results of the carried-out research the statistical analysis of primary information was used. 

The results of the study outcomes of tick-borne encephalitis in adults in the Tomsk Region. Patients conducted a comprehensive clinical and laboratory examination. Revealed the prevalence of autonomic disorders in individuals who have had at different periods of tick-borne encephalitis, which is regarded as the effects of tick-borne infection. Residual effects of tick-borne encephalitis occurs mainly in the form of light paresis after suffering a focal forms. Among the chronic (progredient) forms of tick-borne encephalitis often formed hyperkinetic options. Most of the study revealed the presence of precipitating factors that could have an influence on the outcome. Fundamental diffe rences in all-clinical and immunological analyses at patients with various outcomes of tick-borne encephalitis it wasn't noted. KEY WORDS: tick-borne encephalitis, Tomsk Region, the outcomes.

As a result of survey of 190 children with paroksyzmal conditions, there were revealed 14, whom antiepileptik therapy was prescribed after fist seizure. It was defined that such therapeutic tactics may be justified in patients with organik damage of the brain, focal neurological symptomatik in case of spontaneous emergence of the first seizure. 

At patients with carotid endarterectomy the relative assessment of total intravenous anaesthesia with use propofol, penetrating blockage of a cervical plexus and inhalation sevofluran is made. Markers of cerebral damage, a state of the highest mental functions were investigated. It is shown that for each kind of anaesthesia are characteristic specific level neuronal damages that affects on a state of the highest mental functions, number and character of postoperative complications. In therapy of neurologic complications and preventive maintenance cognitive distresses clinical efficacy ceracson is shown. 

137 (274 eyes) relapsing-remitting multiple sclerosis patients have been given detailed neuroophthalmologic examination. 58 of these patients (74 eyes) had a previous history of optic neuritis. As a result, the most informative methods of examination have been identified. These include the estimation of the frequency characteristics of the vision (vizokontrastoperimetriya, low-contrast tests Sloan), standard static automated perimetry, pattern visual evoked potentials, and optical coherence tomography which is used to measure macular volumes and retinal nerve fiber layer thickness. The above – mentioned methods make it possible to reveal the involvement of the optic analyzer in the inflammatory and neurodegenerative process at the pre-clinical stage. The obtained results allow us to recommend inclusion of the methods in the standard algorithm for the examination of patients with probable multiple sclerosis. 

Acute disorders of cerebral circulation remain serious medical and social problem associated with high disability and mortality rates. Since 2011 Tomsk oblast is a participating member of the medical campaign aimed at improved medical services to the vascular patients. The preliminary implementation data analysis for 2012 revealed improvement of most of the indices of medical support to patients suffering from acute cerebral circulation; increased number of the in-patient cases (Regional Vascular Center and primary vascular department), decreased lethality rates from strokes, specifically hemorrhagic cases. Strict observance of the Regulations on Medical Assistance for stroke patients and the using of modern methods of therapy allowed to decrease hospital mortality in the Primary Vascular Departments and early mortality in the Regional Vascular Center. The active implementation of neurorehabilitation approaches resulted in the increased number of patients who do not require third parties’ assistance. Analysis of the work of the departments helped to identifying current problems and perspectives of further development of special medical care for stroke patients.

To date, there is no consolidated opinion regarding the terminology and classification of bruxism. The following terms are used for determination of unconscious strong compression teeth: “effect Karolyi”, “stridor dentium”, occlusal neurosis, odonterizm, “bruksomaniya”, “parafunctional activity of masticatory muscles”. Because of the disease nature the polyethiologic symptom group is develops that complicates the disease representation. The authors are recommend the usage “bruxism” term in everyday practice and as the most well-established and popular in the medical practice. The primary point of our study was identification of the pathognomonic parameters on electroencephalogram in patients with bruxism. As result of the study it was identified that the border type of EEG was registered statistically higher in pa-tients with parafunctional activity of masticatory muscles than in control group. The results are consistent with global trends, in respect that neuroscientists are systematize bruxism to “parasomnias”, (according to ICD 10) which are characterized by minor changes in the basic rhythm which were identical to findings that we revealed in the study group.

The review summarizes current data on the role of insulin in the regulation of t glucose metabolism in the central nervous system at physiologic and pathologic conditions. For many years, the brain has been considered as an insulin-independent organ which utilizes glucose without insulin activity. However, it is become clear now that insulin not only regulates glucose transport and metabolism, but also has modulatory efftects in impact on excitability, proliferation and differentiation of brain progenitor cells, synaptic plasticity and memory formation, secretion of neurotransmitters, apoptosis. We have critically reviewed literature information and our own data on the role of insulin and insulin resistance in neuron-glia metabolic coupling, regulation of NAD+ metabolism and action of NAdependent enzymes, neurogenesis, brain development in (patho)physiological conditions. The paper clarifies interrelations between alterations in glucose homeostasis, development of insulin resistance and development of neurodegeneration (Alzheimer's disease and Parkinson's disease), autism, stroke, and depression. We discuss the application of novel molecular markers of insulin resistance (adipokines, α-hydroxybutyrate, BDNF, insulin-regulated aminopeptidase, provasopressin) and molecular targets for diagnostics and treatment of brain disorders associated with insulin resistance.

Examination of 70 patients with different options of a course of multiple sclerosis is conducted. Reliable decrease in thickness of a layer of a neuroepithelium and macular volume of a retina at patients with various options of a course of the multiple sclerosis, more expressed is noted at primary progressing and secondary progressing current options, and the patients who have transferred an optical neuritis. The functional violations at the level of an optic nerve according to the visual caused potentials – increase in a latence and decrease in amplitude of the P100 component are revealed. Possibility of application of methods of an optical coherent tomography and the visual caused potentials for diagnostics and monitoring of pathological process is shown at multiple sclerosis.

Violation of visual functions and oculomotor frustration develop at 90% of patients with MS. More than a half of patients are transferred by the numerous recurrence of an optical neuritis which is coming to an end with a partial atrophy of optic nerve. For well-timed purpose of pathogenetic treatment differential diagnostics with other diseases, being accompanied an atrophy of an optic nerve, in particular with Leber's disease. 

Schilder’s leukoencephalitis was described by American neurologist and psychiatrist P.F. Schilder (1886– 1940). At present the pathology is regarded as acute diffuse form of multiple sclerosis, and it is characterized by demyelination of the brain. Clinical manifestations of pathological process varied. The disease is a rare, usually in children and adolescents. In patients older than 40 years of death can occur in a period of 6 months to 3 years from the onset of the first symptoms. Considering the rarity of the disease, we present a clinical case with autopsy data from our practice. 

The history of the development of the Tomsk Scientific School Neurologists and the past and current events in the Department of Neurology and Neurosurgery of Siberian State Medical University are described. The Department of Neurology was established in 1881–1882. At a different times the department was headed by many great Russian physicians such as Michail G. Kurlov, Leonid I. Omorokov, Nikolay V. Schubin, Nikolay I. Komandenko. In addition to the academic work the department leads research in many fields of neurology, including movement disorders, cerebrovascular diseases, demyelinating and paroxysmal diseases.