EXPERIMENTAL AND CLINICAL INVESTIGATIONS
Establishing informative of 3-phase scintigraphy in the evaluation of blood flow and identify pyo-inflammatory process in patients with neuropathic, ischemic, and mixed forms of diabetic foot. This study includes the results of three-phase scintigraphy of 76 patients with diabetes mellitus and with suspicion of osteomyelitis in diabetic foot. Results were verified with morphological study in 39 patient.
In patients with diabetic foot the depression of the main vessels blood flow and blood flow prevalence the changes intraosseous blood flow. Comparison of scintigraphy and morphological studies confirmed the highly informative three-phase scintigraphy in the evaluation of main and peripheral blood flow. 3-phase scintigraphy revealed a lower specificity (66.7%) in the diagnosis of osteomyelitis in patients with diabetes mellitus at the sensitivity (94.7%) and accuracy (73.7%).
Three-phase scintigraphy is high-performance method in revealing the arterial and peripheral blood flow disorder in patients with diabetes mellitus. The low specificity of the three-phase scintigraphy with high sensitivity indicate the limited possibilities of the method in the identification of pyo-inflammatory process in patients with diabetes mellitus. The observed preservation of blood flow makes it possible to expand the employment of methods of nuclear medicines and apply scintigraphy with labeled leukocytes for indicating purulent infection in patients with complicated course.
34 patients with diabetes mellitus type 1, who have been diagnosed diabetic nephropathy varying degrees of severity were examined. Assessment of renal hemodynamics with the help of ultrasound examination of the renal arteries with the use of the Doppler techniques. Revealed violations of the high-speed indicators at the level of interlobar and arc renal arteries, which as the progression of diabetic nephropathy will be revealed in the blood vessels of the kidney over a large caliber (segmental and stem). Significant difference of the resistance index compared with the control group were not found.
uvenile idiopathic arthritis (JIA) belongs to a heterogeneous group of chronic inflammatory joint diseases in children, which begin under 16, tend to progressive joint disease involving synovium with chondrolysis, destruction of bone structures, and often formation of ankylosis.
To reveal structural changes in knee joints, 25 children with JIA were passed through ultrasonic examination with the use of 7.5—11 (14) MHz linear sensors in superscale mode with energy and color Doppler mapping. Standard laboratory indices, rheumatoid factor (RF), and modified citrullinated vimentin antibodies (MCVA) in blood serum by the ELISA method were determined as well. The JIA activity was assessed using the DAS28 index. In the examination of knee joints in the group with JIA, most characteristic changes were uniform synovium thickening (68% of cases) with proliferation and vascularization (in 50% at proliferation), joint capsule effusion (56% cases) with mean values of (4.16 ± 2.47) mm. Reliable correlation has been revealed between synovium vascularization and MCVA level, erythrocyte sedimentation rate, and DAS28 activity, as well as thickness of joint effusion with MCVA level.
CT and MR patterns of focal perfusion and diffusion disorder are compared in groups of patients with nonhemorrhagic venous and ischemic stroke, as well as in control group with chronic brain ischemia. The rMTT(+ vs. ++), rCBF (± vs. – –), rCBV (+ vs. ±), rDWI (± vs. +), and rADC (+ vs. –) patterns are determined as reliably distinguishable (p < 0.05), which is indicative of congestion in venous stroke focus as a releaser of pathophysiological mechanism of development of secondary ischemia.
In order to assess the possibility of applying the methods of radiation diagnosis of visceral obesity in the metabolic syndrome in clinical practice and compare their results with indicators of carbohydrate and lipid metabolism were examined 78 patients (38 men and 40 women), mean age (45.9 ± 15.5). All patients underwent computed or magnetic resonance imaging according to standard procedure, an ultrasound evaluation of various parameters: the thickness of visceral fat, subcutaneous fat, and their ratio, the thickness of preperitoneal fat in the target level. Based on the application of ROC-analysis identified thresholds for all radiological methods, a comparative analysis of the studied diagnostic models (tomographic methods and the ultrasonic method) compared with the anthropometric measurements (WC/HС). Using these results, the algorithm was ray studies of visceral obesity in patients with metabolic syndrome.
Focal formations of the liver are the result of a large number of benign and malignant processes. Actual an early and accuracy differential diagnostics of pathological processes, as the tactics of the patients depends on the nature formations. Ultrasound plays a key role in the diagnostic algorithm as it is a widely used, does not carry radiation exposure, does not require a lot of time and economic costs. The use of contrast agents can improve the sensitivity, specificity and diagnostic accuracy of ultrasound. Development and introduction in medicine the new domestic contrast agents requires their preliminary studies in an experimental model. However, to date, unambiguous recommendations for creating a model of focal liver damage does not exist.
THE RESULTS OF YOUNG SCIENTISTS’ AND STUDENTS’ INVESTIGATIONS
THE PAGE OF PRACTICAL DOCTOR
The aim was to study the features of CT scan of large intestine in coloproctological patients. 738 patients with colorectal neoplasm and inflammatory bowel diseases were included in the study and underwent abdominal CT scan and CT colonography. Retrograde air opacification of large intestine is indicated in cases of colorectal cancer, water-soluble contrast agent opacification — in diverticular disease, water opacification — in ulcerative colitis.
An efficient modern method for treatment of uterine fibroids is embolization of uterine arteries (EUA). It can be applied at single and multiple uterine fibroids. In most patients, myomatous nodes regress or resolve, bad symptoms reduce or disappear. EUA can also be made in women of reproductive age as an organ-preserving surgery allowing child-bearing in the future.
The presented clinical case demonstrates capabilities of ultrasonography and MR imaging in diagnostics of combined developmental defect of spine (disorganization, wedge-shaped vertebra, scoliosis) and spinal cord (diastematomyelia) in fetus of 21th week of development confirmed by pathomorphological study.
Results of carrying out a technique of a virtual colonoscopy to 15 patients with clinic of an adhesive illness with the instruction on features and comparison among themselves various modes of visualization of the program module of a virtual colonoscopy are described. 5 clinical cases with an illustration of the revealed changes are given.
The combined ray diagnostics has been used to estimating the degree of joint injury at hemophilia and advisability of osteodensitometric monitoring of the level of mineral density of bone tissue before and after endoprosthesis replacement of large joints in hemophilic patients living in Kazakhstan. The study has been carried out at the Chair of Radiology No. 1 of the Medical University of Astana. The results of examination and treatment of 43 patients with hemophilic arthropathia of large joints have been analyzed. The patients were treated in the Polytrauma Department in the period of 2010 to 2011 inthe Republican Scientific Center of Emergency Medical Aid (Astatna), where endoprosthesis replacement of large joints in hemophilic patients have been conducted for the first time among countries of Central Asia and highly efficient methods of early diagnostics (osteodensitometric instrumentation) have been implemented. This has allowed the timely prophylaxis, treatment, and rehabilitation of patients with osteoporosis and hemophilia, as well as prediction of stability of endoprosthesis in postoperative period.
To establish the informativeness of MRI in detecting lesions in patients with intra-articular structures of juvenile idiopathic arthritis was performed MRI and radiography of hands six patients (11 hands) at the age of 10 to 17 years old (the average length of illness (42.0 ± 20.5) months)
A wide range of changes in bone and soft tissue structures, including synovitis, bone erosion, tenosinovitis, bone marrow edema revealed. The advantage of MRI compared with radiography identified erosions in the amount of different localization. The proliferation of established synovitis, compared with the MRI data of clinical and laboratory parameters of inflammatory activity widespread. The data obtained from MRI can be used for diagnosis, prognosis and monitoring response to treatment, including early stage disease.
Peculiarities of clinical progression and X-ray pattern of inflammatory lung changes in patients having five-month to two-year long desomorphine addiction are described based on clinical and X-ray analysis of 187 patients with desomorphine addiction.
FROM SCIENCE TO PRACTICE
The results of check-up of 65 women with sterility in extracorporal fertilization (EF) program are presented. Radiothermometry was used to estimate the influence of ovulation induction on the state of breast. The dependence of changes of breast temperature on the patients’ age, pregnance in EF program, scheme of ovulation induction, number of EF attempts, gonadotrophin dose, amount of oocytes received in the EF program, presence of Ovarian HyperStimulation Syndrome (OHSS) , and level of preovulatory E2 have been analyzed. A tendency to an increase of breast temperature in women in the Assisted Reproductive Treatment (ART) program has been revealed. It correlates with the number of EF attempts, gonadotrophin dose, amount of received oocytes, presence of OHSS, and level of preovulatory estradiol, which may be indicative of increased proliferative activity in this cohort of patients. The method of microwave radiothermometry can be used to estimate and monitor the functional state of breast in women of any age without dose load.
In article are illuminated methodical aspects of the undertaking computer tomography with bolus contrasting in vascular mode, for the reason diagnosticses of the damages pelvic organ and vessel at fracture of the pelvis and in examination for planning untypical surgical access at given groups patient. It is Noted need of the using computer-tomography angiography at damaged with plural nature of the damages, for estimation of the relations vessel with bone fragments and inside the pelvis haematomas.
The study deals with development of a method for prediction of postsurgical dynamics in patients with с multivascular ischemic heart disease and postinfarction left ventricular aneurysm with the aid of linear discriminant analysis technique based on results of MR imaging of heart with contrast enhancement.
Radionuclide renoscintigraphy of 61 patients were investigated before and after coronary angiography for evaluation of the contrast media (CM) nephrotoxicity. Iohexol, iobitridol and iodixanol were used as CM. The parameters of filtration and excretory renal functions were calculated. It is shown that iodinated radiocontrast agents have, in general, moderately negative effect on renal functional parameters.
In order to identify the features of semiotics ultrazvukovoyh uncomplicated and complicated postoperative period after electrosurgical endometrial ablation, evaluate the effectiveness of organ-saving treatment for patients with proliferative processes conducted echographic monitoring of the pelvic organs. The optimal timing of ultrasonography: 3rd day to diagnose hematometra,
7th, 12th day of suppurative complications, 45 day evaluation of the effectiveness of ablation.
A total of 343 polytrauma patients (109 of them with cranio-thoracic trauma) of Omsk city emergency hospital № 1 during 2009—2011 were retrospectively analyzed with regard to supplementary and new findings obtained by digital X-ray and whole body multispiral computer tomographie. The optimum algorithm of diagnostics of patients with a cranio-thoracic trauma is developed.
The article analyses MR examinations of 160 patients with interstitial acute pancreatitis, in absence of MR signs of necrosis of pancreatic parenchyma; the incidence of fluid collections and their outcomes are estimated. Small single fluid collections in the first day after an attack of acute pancreatitis were revealed in 27.5% of cases, multiple and large fluid collections without signs of parenchymal necrosis were revealed in 15.6%. Follow-up MR examinations showed full resolution of peripancreatic fluid collections in 78.7% of cases. Resistant unencapsulated and partially encapsulated collections were found in 7 of 47 patients (14.9%). Local complications requiring surgical intervention developed exclusively in patients with fluid collections and amounted to 1.9% of the whole group of 160 patients, and 6.4% of patients with acute pancreatitis without signs of necrosis of pancreas and peripancreatic fat, but with fluid collections.
The authors came to the conclusion that routine MR examinations of patients with interstitial acute pancreatitis were indicated for patients with fluid collections to estimate the dynamics of changes (resolution of collections or development of complications).
The aim за this study was to estimate capabilities of magnetic-resonance imaging in diagnostics of patients with obstructive jaundice syndrome. Magnetic-resonance imaging was made for 112 patients with biliary hypertension. Malignancy was found in 31 (27.6%) cases случае, mostly in men and mostly cancer of the head of the pancreas. Noncancerous genesis in 74 (66.1%) cases was mostly represented by cholelithiasis and most often in women.
Retrospective analysis of 78 MR images of fetus has shown 30% of coincidence of MR-imaging and ultrasonographic diagnoses, 37% of different diagnoses, and 33% — adjustments of ultrasonographic diagnosis and obtaining of additional information with MR imaging in 63% cases. The results obtained demonstrate clearly that MR imaging should be included in the algorithm of pregnancy follow-up, if some signs are revealed by ultrasonography.
We examined 25 patients with Stage I—II COPD to study diagnostic capabilities of ventilation-perfusion pulmoscintigraphy in relation to the assessment of lung microcirculation and ventilation disorders. Scintigraphic studies were performed by means of the Omega 500 gamma camera (Technicare, USA— Germany). COPD is characterized with the bilateral increase in the apical-basal grade of perfusion and deceleration of the alveolar-capillary permeability. The detected changes of scintigraphic parameters can be used in COPD diagnostics.
ISSN 1819-3684 (Online)