Fifty five Khakas people with Helicobacter pylori-associated ulcer disease and chronic gastritis were examined in order to estimate the production of IL-2, IL-4, and IL-10 interleukins in patients with chronic Helicobacter pylori persistence. The subpopulation composition of lymphocytes of peripheral blood was determined by the method of flow-through cytofluorometry. Apoptosis was estimated by the method of optical microscopy. The IL-2, IL-4, IL-10 production in supernatants was determined by the solidphase immunoenzymometric method. Changes revealed in the blood of patients infected with Helicobacter pylori were characterized by the increased amount and subpopulation disbalance of lymphocytes, apoptosis modification, and depletion of lymphocyte functional activity.

Aim of the study was the determination of the personal and situational anxiety, neurotizm and life satisfaction levels. Study’s materials were 146 patients with vibration disease. All patients underwent the neuropsychologic analysis. Increased anxiety level as the stable personality characteristic was registered in all subgroups of the main group. Described above changes speak for the practicability of the active detection of the affective qualm sphere’s disorders in this cohort of patients with subsequent medicated and non-medicated correction.

Original surgical treatment for tracheobronchomalacia using external stabilization of movable segment with titanium nikelide implant has been developed. The experimental study was performed on 10 mongrels. Tracheomalacia was created by submucosal resection of tracheal cartilages. Efficacy of the method was tested using clinical, radiological, endoscopic and morphological examination. It is ascertained, that the technique permits to eliminate redundant mobility of tracheal segment simply and reliably.

The morphological structure of the chorion villi in I trimester of pregnancy is studied at ureaplasmas and mycoplasmas infections. Established signs of the accelerated maturing of the villi, strengthened proliferation of trophoblast, increased of stromal and vascular components of chorion have been revealed.

Research objective was to compare effects of transplantation of cells and their nucleus on model alimentary dislipoproteinemia. Experiment is executed on the rabbits containing on an atherogenous diet. In blood serum of animals studied changes of a lipide exchange, in a liver — level of stresses-proteins, morphological changes and the maintenance of markers of an apoptosis and a proliferation. Also estimated the area of atherogenous plaques and a thickness of intima of an aorta. It is shown that unlike cellular transplantation, introduction of nucleus led to more expressed therapeutic effect and inhibition of expansion of leading links of an atherogenesis.

The development of a combined approach to the treatment of patients with gall-bladder dysfunctions in combination with chronic opisthorhosis with allowance for all aspects of the pathological process remains an urgent problem of clinical medicine. The addition of tonic procedures to the treatment increases the adaptation capability of an organism. Symptomatic factors (pulsed travelling magnetic field) favors normalization of the functional state of the biliary excretion system. The anthelminthic therapy (ecorsol herbal drug) results in specific antiparasitic effect. In combination, the used methods provide for the high effect of performed medical and prevented measures favoring not only the reduction of pathological process, but also the prevention of its progress, which is great practical importance.

We evaluated the frequency distribution of polymorphic variants in DNA repair genes XRCC1 280, XRCC1 194, XRCC1 399 and XPD 751 gastric cancer patients and healthy controls, leading to new fundamental knowledge and molecular genetic markers of gastric cancer. Statistically significant differences were identified in the two groups for the three excision repair gene XRCC1 280, XRCC1 399 and XPD 751, relative risks were calculated of gastric cancer in carriers of the minor variants of these genes.

Investigation of influence of gases nitric oxide and hydrogen sulfide on apoptotic cell death of Jurlat cells and mononuclear leucocytes of healthy donors was conducted. It was shown that 100 mmol sodium nitroprussidi increased the apoptosis of T lymphoblast leukemia cells after 15’ incubation. 10 and 100 mmol donor of hydrogen sulfide caused apoptotic death of Jurkat cells after 15’ incubation. 15’ exposure of nitric oxide and hydrogen sulfide donors did not lead to the changes of cell death of mononuclear leucocytes. Gaseous transmitters NO and H2S increased necrosis of Jurkat cells and mononuclear leucocytes after 24 h incubation with the appropriate gase’s donor.

In the analysis of known ways to prevent adhesions, by which the proposed alternative effects on the formation of adhesions in the abdominal cavity. We analyze the effect of antioxidant complex formation of adhesions in the experiment.

Aim of the research — to define the tiotropium bromide influence on bronchial neutrophiles and macrophages morphofunctional properties at stable of chronic obstructive pulmonary disease (COPD). The tiotropium using for 3 months has allowed to improve essentially qualitative characteristics of key effectors cells. The revealed changes were observed in all groups of patients irrespective of a previous mode of COPD treatment.

Morfoquantitative and ultrastructural analysis of the specific volumes of blood and lymph vessels in the periodontal first molars and premolars with different surfaces (medial, distal, buccal, and palatal) and at different levels of the roots are studied. It was noted that at physiological pressure on the molars and premolars, the specific volume of the investigated values are different. Throughout the root of the observed two zones of compression and expansion of periodontal. Depending on these areas of blood and lymphatic vessels was significantly different.

Results of the complex research of apoptosis realization of lymphocytes at acute tick-born encephalitis and during long antigenemia condition has been presented in this article. The acceleration of apoptosis, tumor necrosis factor I presentation and the decrease in mitochondrial transmembrane potential of lymphocytes were determined at tick-born encephalitis. Uncovered changes are more appeared at acute neuroinfection.

Despite of the obvious progress in posttraumatic larynx and trachea stenosis’s treatment during the last time surgical therapy of the laryngotracheostoma is still urgent issue. A tracheostoma’s plastic closure is fundamental and terminal method in treatment such diseases, this findings are confirmed by the literature review. To conduct such a treatment nowadays best methods and transplant materials are looked for.

Mental and behavioral personality disorders provoked by substance use — alcohol and drug addictions — are similar in genesis and social consequences and this dictates necessity of gnoseological understanding of terminological apparatus of this phenomenon. Understanding of use of narcotics as a common criterion of gnoseology may testify that namely community comes forward as criterion of summarized data about considered addictions and capacity of knowledge allows considering drug and alcohol abuse as equivalent ones according to their social significance and pathogenetic patterns.

Magnetic resonance imaging (MRI) is primarily used in medical imaging to visualize the structure and function of the body and essential tool for diagnostics of broad range of pathologies. But still in a growing number of cases there are indications to use contrast agent to delineate areas of interest and for more precise diagnosis definition. In a review the properties and clinical applications of most popular paramagnetic contrast agents based on Gd(III), Fe(II) и Mn(II) are discussed. It is also focused on discussion of modern experimental targeted contrast agents (conjugates of antibodies, nanoparticles and dendrimers) and advances of their application for early diagnostics of most common pathologies: cardiovascular, cancer and Alzheimer diseases.

Allergy to cow's milk is characterized by early onset and high prevalence in pediatric population. The review presents current data on the molecular structure, physicochemical and allergenic properties of the cow's milk proteins. The patterns of the natural history of cow's milk allergy are described. The aspects of the development of tolerance to the proteins of this product are performed.

Fault in T-lymphocytes homeostasis leads to different diseases with poor or vise versa strong immune response. So it seems to be interesting to research molecules of T-cell cooperation to develop new more effective therapeutic methods. Important factor modulating T-cell activity is galectin-1 which takes part in multiply process of cell biology — regulation of cell maturation, migration, signal transduction, functional ability and apoptosis.

126 patients with histological diagnosis of Hodgkin and non-Hodgkin lymphoma were examined using combined positronemission and computed tomography with radiotracer 18F-deoxyglucose. For staging Ann Arbor classification (1971) with Costwolds modification (1989) was used. The combined positron-emission and computed tomography pattern of Hodgkin and non-Hodgkin lymphoma was established. Morphofunctional characteristics of lymphoma were determined in cases of lymph node, spleen, liver, kidneys, bones and lung lesion. Using combined positron-emission and computed tomography it can provide more accuracy in staging of Hodgkin and non-Hodgkin lymphoma.

The effects of pulse periodic microwaves (10 GHz, duration of pulse 100 ns, pulse repetition frequency 4—19 pps, peak power density 40—1 520 W/cm2 ) on the reparative regeneration of full-thickness skin wounds on mice was investigated. This effect depends on the pulse repetition frequency and peak power density.

Obesity associated with the enhanced risk of cardiovascular disorders plays a key role in the evolvement and progression of type 2 diabetes mellitus (DM2). Incretin mimetics are the sole class of hypoglycemic agents that not only effectively correct hyperglycemia but also reduce body weight. Exenatide (Byetta, Eli Lilly, USA) is the first drug of this class approved for the use as monotherapy. This paper presents data of clinical studies and owns data on the effectiveness of the drug Byetta in achieving metabolic control and weight correction in patients with type 2 diabetes.

There were 46 children with chronic otitis media with effusion (OME) under the supervision. After carried out virologic research by immune-enzyme analysis, polymerase chain reaction, metod-immunofluorescence-antitel, prevalence Epstein-Barr virus infection — 41 person (89,1 %), a smaller part children with respiratory syncytial virus — 18 children (39,1 %) and adenovirus infections — 15 children (32,6 %) — are noted. All patients were undergone surgical treatment — middle ear bypass surgery, after the surgery the thirst group patients received antiviral drug while the second group patients received standard treatment. Inclusion antiviral drug into the OME treatment algorithm decreases terms of patient¢s treatment.

In the article problems of system engineering of telemedical consultations are considered, the analysis of world approaches to their construction is carried out. The group of authors represents the developed system of asynchronous telemedical consultations, its architecture and advantages before existing analogues.

Complex kliniko-tool, laboratory, psychovegetative investigation of 139 various aetiologies sick by a cirrhosis (virus, alcoholic, mixed) is carried and severity levels on Childs-Pugh. The comparison group has been presented by 104 sick chronic hepatitises virus, alcoholic and mixed aetiologies. The control group included 30 healthy the person comparable floor and age. At sick of a cirrhosis, also as at sick of a chronic hepatitis, emotionally-labile, neurotic lines and high personal uneasiness prevailed. The tendency to sympathicotonia depended on weight of defeat of a liver. Prevalence of a tone and reactance of sympathetic department of vegetative nervous system is a compensatory strengthening of adaptive mechanisms.

Ultrasound examination is the integral component of diagnostic imaging and it is widely used method for medical visualization in Russian clinical medicine. Modern diagnostic imaging inseparably linked with use of contrast agents. Currently, the use of echo-contrast agents is a compulsory condition for patient's examination with constant improvement and development of new echo-contrast agents. In Russia these agents are not widely used due to insufficient duration contrast procedure and high cost of examination. However, during the last years there are factors promoting the development and introduction of echo-contrast agents into the national market.

In 17-year nested prospective study, the natural dynamics of hypertriglyceridemia (HTG) (development of new cases, regress), cardiovascular mortality and other mortality of patients with HTG have been examined. The nest included 630 men and 916 women from 20 to 59 years old. The HTG incident in the nest was 8.24 cases per 1000 people*years of observation. Among people 20—29 years old, new HTG cases were observed more often in men, while in the age interval of 30—59 years, new cases were more often observed in women. For the period of observation, the HTG occurrence increased 1.6 times in men and 2.1 times in women. HTG is characterized by the low course stability, and the regress level is independent of sex. Among men and women, Among men and women with HTG, brain stroke and cardiovascular mortality is higher than that among people with the normal triglyceride (TG) level. The TG level did not affect the total men mortality.

The total nonelastic work of respiration (TNWR) was studied in 18 healthy people and 11 patients with the chronic obstructive pulmonary disease with the aid of simultaneous recording of transpulmonary pressure and volume. It was found that under the conditions of identical pulmonary minute volume at air flow interruption by valve, TNWR becomes larger compared to that at quiet deep breathing. The additional resistance was called acophased and was considered as a manifestation of independent mechanical pulmonary activity.

The creative biography of Professor M.S. Yusubov, prominent scientist, head of Chemistry Chair of Siberian State Medical University is presented, his main trends of scientific and public activity are concerned.

Feliks Ivanovich Yershov (to 80th birthday).