Several autoimmune diseases with chronic clinical course are characterized by detection of DNA autoantibodies in patients’ serum, while there are no such IgGs in healthy donors’ blood or in patients with acute clinical course with no evidence of chronization. Tick-borne encephalitis has not been considered this way. Several strict criteria have been applied to show that the DNase activity is an intrinsic property of IgGs from the sera of TBE patients but not from healthy donors. The relative activity of IgGs has been shown to vary extensively from patient to patient, but most of the preparations (91%) had detectable levels of the DNase activity. Polyclonal DNase IgGs were not active in the presence of EDTA or after a dialysis against EDTA, but could be activated by several externally added metal ions, with the level of activity decreasing in the order Mn2+ + Ca2+ ≥ Mn2+ + Mg2+ ≥ Mn2+ ≥ ≥ Mg2+ + Ca2+ ≥ Ca2+ ≥ Mg2+ > Ca2+, while K+ , Na+ , Ni2+, Zn2+, and Cu2+ did not stimulate DNA hydrolysis. Affinity chromatography on DNA-cellulose separated the DNase IgGs into many subfractions with various affinities for DNA and very different levels of the relative activity. Possible reasons for catalytic diversity of polyclonal human Abzs are discussed.

We investigated the effectiveness of Copaxone in patients with relapsing-remitting multiple sclerosis for 3 and 5 years. Significant improvement found the decrease of the frequency of clinical exacerbations and delay the accumulation of physical disability during treatment period.

53 patients with traumatic brachial plexopathy were exsamined during the clinical and elektroneuromyographycal study. It was determined that the structure of traumatic brachial plexopathy had 5 types of injury: upper Erbs palsy (С5—С6) (28,3%), lower Klumpcs palsy (С8—Th1) (15,1%), whole palsy (С5—Th1) (18,9%) and 2 groups of combined plexopathies with paralyses of flexible muscles of upper arm and fingers (С5—С7) (16,9%) and paralyses of extensible muscles of forearm and hand (С6—С8) (20,8%). 3 variants of disturbanses of nerve fibres were found during the experiment. They were axonal variant for whole palsy, Erbs palsy and injury of motor fibres for Klumpcs palsy. Combined type of injury was characterized for whole palsy, extensible paralyses (С6—С8) and injury of sensory fibres for Klumpcs palsy. Demyelinizationary type of injury was characterized for combined flexible paralyses (С5—С7).

Determination the tactics of the treatment and rehabilitation of the patients with myofascial face pain syndrome (MFFPS). The complex of clinical and radiologic diagnostic methods to 83 patients with myofascial face pain syndrome and mandible movement disorder have performed. Patient examination have made it possible for to define succession and efforts, to reduce pain syndrome intensity, to normalize mandible movements. MFFPS treatment requires the participation of stomatologist, neurologist, roentgenologist, psychologist, therapeutist.

Early carbohydrate disturbances (ECD) influence cerebral stroke development and course. Prevalence and co-morbidity of different carbohydrate metabolism types were studied in 107 cerebral stroke patients. It was determined that different disturbances developed in 70% of cerebral stroke patients. Even ECD negatively affected cerebral stroke course.

We evaluated clinical and laboratory findings in 86 patients of 4—16 years old. Data showed that in all forms of tick-borne infections S100 concentration increased. In meningeal forms of tick-borne infections the S100 level was highest in cases of prolonged progression. The results let conclude that increasing of S100 concentration in all clinical forms of tick-borne infections reflexes the severity of CNS disturbances and their correlation with clinical manifestations.

The initial vegetative tonus and vegetative reactivity were studied in patients with neuroreflectory syncopal states (NSS) during passive orthostatic testing in the orthostatic and clinical phases. The variability of the heart rhythm was estimated on the Neiron-spektr device. During the orthostatic testing, the insufficient activity of the sympathetic part of the nervous system in NSS patients was observed compared to the control group. During the clinostatic testing, the indices of NSS patients approached the normal values.

To assess peculiarities of cerebral blood flow in patients with hypoplasia of vertebral artery, 100 patients were examined. Patients after acute ischemic stroke, chronic ischemic diseases, and a group of healthy patients were separated. In patients with acute ischemic stroke, a reliable decrease was found in the degree of blood flow increment in the posterior cerebral artery at rhythmic photostimulation, as well as in the total volume blood flow in the vertebral-basilar basin.

Parkinson’s disease (PD) is a progressing neurodegenerative disorder is exhibits clinically by bradykinesia, tremor, rigidity, and postural instability. Cognitive impairment were observed in 88,8% patients: mild cognitive impairment in 36,1% and dementia — in 63,9% patients.

Hypopituitarism is often developed in the result of operative treatment of tumours in chiasmal-cellular area. One of frequent indications of hypophysis’ deficit is decreasing of product of thyroid-stimulating hormone (TSH) that leads to deficit of thyroid hormones. Most patients, who had been operated in terms of tumours of chiasmal-cellular area, have normal volume and structure of thyroid gland in the background of decreased level of free thyroxine and absence of increasing of level of TSH on the principle of feedback, it indicates to the secondary character of destruction of thyroid gland. Patients operated in terms of craniopharyngioma and somatoprolactinoma more often have secondary hypothyroidism. A high per cent of fibrotic changes of tissue of thyroid gland in patients operated in terms of prolactinoma is explain by autoimmune thyroiditis in anamnesis.

The study explored the life quality of 94 multiple sclerosis patients in comparison to healthy respondents and in dependence to different parameters of the disease with the use of SF-36 questionnaire. The study has discovered a decline of all the factors of life quality and their dependence on disablement intensity, clinical course and duration of the disease. Immunomodulatory therapy contributed to the improvement of life quality factors.

Examination of recovery dynamics of cognitive impairments in patients with ischemic stroke and with or without alcoholic encephalopathy was conducted. It was shown that in patients with ischemic stroke and alcoholic encephalopathy dementia prevails, and positive dynamics is extremely rare.

The incidence of epilepsy and epileptic syndromes (number of new cases per year in a given population) in children and teenagers of Tomsk Region was 44.10 per 100 000 people, being higher in children (49.60) as compared to teenagers (27.39). The prevalence (number of active cases per unit population) was 3.53 per 1 000 people and differs among regions (from 0.74 to 10.95). Most of patients suffered from symptomatic (45.58%) focal epilepsies with predominantly temporal lobe epilepsies (42.04%). The most common etiologic factors of symptomatic focal epilepsies were hypoxic-ischemic perinatal encephalopathies and developmental brain disorders (15.9%). 24.26% patients were switched to politherapy, and others — to monotherapy. Valproates were most often used drug. Remission was achieved in 49.43%.

56 patients with temporal epilepsy (TE) at the age of (30.5 ± 10.0) years under the duration of the disease — (17.5 ± 10.7) years are examined. The examination included the anamnesis, somatic and neurological statuses, ultrasonic medical examination of brain vessels, the magneto-resonance tomography (MRI) of brain. Headaches (HA) among 80.4% patients with TE is revealed and its dependence from different factors is studied. The absence of gender differences, the dependence from the type TE, frequency of attacks and the duration of the disease among patients TE with HA are noticed, however the burdened neurological and obstetrical anamnesis, the presence HA among relatives, changes on data MRI of the brain, pathology of vertebral-basilar basin, the reduction and asymmetry of the index of the vessel resistance are observed. This amends the algorithm of the examination and treatment of patients with temporal epilepsy.

Morphofunctional characteristics were examined in old and middle-age women with ischemic stroke. The severity of the disease has been shown to be explained by the age-dependent deficiency of estrogen as one of risk factors.

2 groups on 35 patients from 32 till 52 years which have transferred an easy fighting craniocerebral trauma. It is spent electroencephalographic (EEG) research, the computer analysis with definition of indexes of the basic rhythms, the vegetative status under the program of variability of a rhythm of heart is studied, functional classes (FC) on D.I. Zhemajtite are defined. At all patients changed types EEG prevailed. It is noted low FC at patients with I, II, V types ЭЭГ. Correlation of type EEG with level FC is revealed: at patients with V type EEG prevailed IV and V, with I and II types EEG — higher (II, III) FC. The high index of an alpha rhythm correlates with high II FC, and a beta rhythm with III FC. Decrease in adaptable mechanisms of vegetative regulation defines necessity of medicament correction.

In the experiment on rabbits were presents, that experimental arterial hypertension didn’t led to functional failure of lymphatic drainage of brain. On the background of beta-blocker obzidan use failure liquor outflow from brain took place.

Spiral CT angiography was used for identify position the top of the loop of the superior cerebellar artery (SCA) in 23 patients classical trigeminal neuralgia (TN). The author describes the defining point, expressed as the position of the loop of the SCA in relation to the root of the trigeminal nerve (RTN) projection. In all 23 observed cases of patients with classical TN the apex of the loop of SCA was located lower of the RTN projection, which confirmed pathogenic role of neurovascular conflict in TN.

The article examines the pathogenesis and clinical features of multisystem atrophy. We present clinical and diagnostic criteria of the disease. The clinical signs of multisystem atrophy patients treated at the Neurological clinic Siberian State Medical University (Tomsk). The clinical case was examined.

The research problem wasstudying of influence of a complex physicaland balneal therapies on endokrinno-metabolic processes and immune system of an organismof participants of confrontations with different forms of chronic diseases for the purpose of working out of adequate schemes of regenerativetreatment. 173 police officers, at the age from 22 till 45 years old which were taking part in military operations in the Chechen republicare surveyed. At receiptin a hospital for patients diagnosed following forms of chronic diseases: a chronic prostatitis, chronic холецистити neurologicdisplays of an osteochondrosis. Schemes of stageby-stage rehabilitation have been developed for correction of the revealed infringementswith appointment of base complexes at the first stage of regenerative treatment. On the basis of studying of dynamics of indicators of the endokrinno-metabolic status and a condition of immune system of an organism of participants of confrontations with various forms of chronic diseases the substantiation of the new approach to correction of the poststressful frustration, consisting in stage-by-stage rehabilitation with appointment at the first stage корригирующего a base complex is presented. The carried outcomparative analysis of efficiency of medical actionsspecifies in expediency of application двухэтапного a rehabilitation course (taking into accountconcrete nosological form) for correction of poststressful frustration at participants of operations.

Comparison of episodic and chronic forms of primary headaches to reveal the possible factors leading to the disease chronicity has been performed. Some of the comorbidities were considered to be the conditions resulting in a more severe course of migraine and headaches of tension. Significant prevalence of clinical manifestations of immune system impairment in patients with chronic cephalgia was noted. It was suggested that the above impairment might be one of the factors accounting for the transformation of course of primary headaches.

Specific defeat of vessels of a brain at a syphilis can be one of the stroke reasons. The results of retrospective analysis of 53 case records of patients early manifest by forms neurosyphilis are resulted in article. The first group included the patients who were not receiving specific therapy concerning a syphilis, the patients treated earlier concerning a syphilitic infection have been included in another. From the given groups patients with cerebrovascular forms of neurosyphilis (only 24) have been allocated. The diagnosis has been verified on the basis of the clinical data, results clinic — laboratory and serologikal researches of whey of blood and liquor, the data of a magnito-resonant tomography, dopplerography researches of a brain blood-groove, compression, hypercapnia tests. Features of a clinical current cerebrovascular forms early neurosyphilis with stroke a current are revealed.

A comparative analysis of neurological manifestations in patients with acute ixodic tick-borne borreliosis (ITB) and patients with ITB associated with chronic opisthorchiasis has been carried out. It has been found that at ITB in the acute phase, nearly all parts of the nervous system are involved in the pathological process. Diseases of central parts of the nervous system were found in 86.7% patients with the monoinfection and in 96.7% patients with ITB associated with chronic opisthorchiasis, diseases of the vegetative part were found in 75.0 and 83.3% patients, and peripheral failures were found in 18.3 and 48.3% patients, respectively. In the structure of neurological pathology of the acute stage of ITB with chronic opisthorchiasis, the prevalence of the combined disease of different parts of the nervous system (93.3%), the more frequent occurrence (96.7%) and higher intensity of headaches (more than 4 points by the visual analog scale), vertigo (76.7%), cognitive failures (35.0%), signs of the vegetative disfunction syndrome (95.0%), and peripheral neuropathy (48.3%) were diagnosed.

The efficiency of treatment of herpetic stomatitis by autonomous porous titanium nickelide applicators with the use of liquid nitrogen was assessed. In 43 patients, the Hossley-Bergman pain index and erosion epithelization terms after the cryo treatment compared to traditional methods were taken into account. The developed treatment method is characterized by the simplicity, low cost, absence of contraindication and side effects.

The goal of the present study was to determine significant diagnostic signs of radiculopathy in the late stage of Lyme disease (LD) and in spondylosis. The pain in patients with radiculopathy and LD was often localized in the place of tick-bite (in 25.5%). The insidious onset of the disease was more typical in LD (in 84.3%), in patients with spondylosis and radiculopathy remissions and exacerbations were typical (62.2%). Inflammatory syndrome, polysystemic changes were typical for LD. In LD the effect of NAIDs was rather poor, the patients improved after treatment with antibiotics.

The study investigates the intravital high-field proton magnetic resonance spectroscopy and superimposed magnetic scanning of brain metabolism in 60 patients showing the association between demyelination activity and the inflammatory or degenerative stage of MS. It also educes Flicker noise phenomenon as a new indicator of a pathologic process progression. The data on the tissue respiration decrease, of the neurotransmitter hypometabolism, energy, and enzyme brain systems were collected to use as the therapy prediction and monitoring of MS.

Influence of the previous antihypertensive therapy on the course of cerebral stroke was analyzed in 188 hypertensive patients. Stroke course features and treatment outcome were analyzed in patients receiving regular antihypertensive therapy before stroke and in those not treated or treated irregularly. Direct influence of previous antihypertensive therapy on the rate of hemorrhagic stroke development, its course severity, and subsequent functional recovery was revealed.

Identification of influence of cardiac pathology on the course of ischemic stroke in patients with different types of constitution, can play an important role in the tactics of treatment and prognosis. The assessment of neurological status in the acute period of stroke depending of the type of cardiac pathology and constitutional features, evaluation of hemostasis was performed. A positive correlation between the existed cardiac pathology with some anthropometric somatotype parameters and their influence on adverse outcome of stroke was revealed.

The Relapsing-Remitting Multiple Sclerosis (MS) patients research has revealed that the matrix metalloproteinase-2 level in cerebrospinal fluid which is higher then 30 ng/ml during the relapse and/or remission period increases repeated relapse risk during 2 years term by 2.8 times. The rapid MS progressing is associated with the high level of adhesion molecule (sPECAM) in cerebrospinal fluid.

In the given work had been lead the analysis of epidemiological data TBE for 1999—2009 on Tomsk area. The information on quantity imparted against tick-borne encephalitis, about results of research of pincers and blood at the persons who have addressed on points prevention of tick-borne encephalitis and about quantity of the diseased tick-borne encephalitis is presented. Analysis of a complex of preventive actions is spent. The reasons of formation of the long maintenance of a virus tick-borne encephalitis in blood are shown.

The state of the nervous-receptor apparatus of teeth without opposing teeth was studied with the aid of electroodontometry. Patients were divided into three groups depending on clinical manifestations of teeth without opposing teeth. In each group, electroodontometry of the teeth was carried out. The results obtained are indicative of morphological changes in the nervous-receptor apparatus of teeth without opposing teeth and without the mastication load.

Differential diagnosis of the multiple focal lesions and expansive process of brain was conducted in 78 patient in early stage of the disease when it was mono symptom clinic. Only MRI helped to make the proper decision.