The main stages of the development of the Postgraduate Formation in Siberian State Medical University are presented. In 2009 was performed 30 years since day of the opening of the Faculty of the Improvement Specialists. Were analysed main totals to activity of the faculty, its formation and development, perspective directions in training high-quality personnel for practical public health.

At patients chronic obstructive pulmonary disease (COPD) average degree of gravity and heavy stages decrease absorption functions of a thin gut is established concerning fats, protein, carbohydrates, progressing with weight of disease, a degree of degenerate-dystrophic changes of a mucous membrane of a thin gut with its infringement regeneration potentialities. The received data are interpreted in a context of interrelation of function, structure of a mucous thin gut and a clinical component. Direct correlation communications between deficiency of weight of a body of patients COPD and decrease absorption functions of a thin gut in the attitude are established albuminum (r = 0,71), fats (r = 0,55), carbohydrates (r = 0,48).

In article results of research of a chemical structure of humic acids of low-moor woody-grassy type of peat of Tomsk Region are resulted by methods of the elemental analysis and infra-red spectroscopy. In this work results of toxicological research of humic acids also are described: acute toxicity, pathomorphology and flow properties of blood. It is shown, that humic acids of low-moor woody-grassy type of peat represent connection with a high share aliphatic fragments submitted long connected by circuits, have a small degree benzenoid, contain active oxygen and itrogen-containing functional groups (carboxylic, hydroxyl, amides, amino groups). It is established, that humic acids at intragastric introduction are nontoxic substances. At intraperitoneal introduction of lethal dozes, the destruction of animals comes from acute intimate insufficiency, thus the cause of acute infringement hemodynamics can be negative influence of humic acids on flow properties of blood.

The research is devoted to study clinico-laboratory implications and indicators of coagulating system of blood at patiens with liver cirrhosis associated with virus hepatitises B, C and D. The group of 100 patients were analyzed. At patients combined the lesion of a liver viruses HCV and HBV met identical frequency with a HBV-infection (34%). The hepatocellular carcinoma is taped in 8% of cases. At 50 patients with a cirrhosis in subcompansation stage researches of coagulating system of blood have been carried out. According to the developed coagulogram consumption coagulopathy development became perceptible.

The absorption function of small intestine has been studied at chronic inflammatory intestine diseases anв assessed depending on the severity of the main process. In groups of patients with ulcerative colitis, Crohn’s disease, and irritable bowel syndrome, as well as in healthy persons, diurnal fat loss with feces was determined by the van de Kamer method, and the D-xylose tolerance test was performed. The disorder of nutrient absorption in patients with chronic inflammatory intestinal diseases is directly proportional to the severity of the main disease.

The aim of the investigation was to study the functional-morphological state of kidney in patients with rheumatoid arthritis (RА). Examination was performed on 75 patients with RA and 25 healthy subjects. In addition to complete clinical and instrumental examination accepted in specialised clinic, biopsy of kidney was conducted. At 62 patients changes in an urinary deposit are taped. According to 25 nephrobiopsies in 12 cases took place mesangioproliferative variant of a chronic glomerulonephritis, the amyloidosis was detected at 5 patients, in 8 cases - vascular changes, the weak and moderate phenomena of a productive vasculitis of arterioles, the capillaries, accompanied by a focal perivascular sclerosis. Nephroprotective effect of basic therapy of RА was found.

We have studied the calcium consumption by nursing mothers and children from risk groups on decreased mineral bone density in different age periods under conditions of Tomsk. The calcium content in breast milk in the first six month of lactation was determined by the method of instrumental neutron-activation analysis. It has been found that the calcium consumption by the most nursing mothers corresponded to physiological norms. In the lactation dynamics, the calcium content in the breast milk decreased at the third month and increased at the sixth month of lactation. The average calcium consumption was (834,3 ± 132,3) mg in children aged of 1—3 and (959,0 ± 99,5) mg/day in children of 4—6 years old. Among schoolchildren, the average calcium consumption was (860,3 ± 98,2) mg/day in the age of 7—10 and (777,9 ± 59,3) mg/day in eth age of 11—18. It is 1,2—1,6 times lower than the recommended norm. In teenagers, the calcium deficit in food is more often compared to preschool children.

Proteolytic systems of tissue and blood plasma take part in the processes of adaptation and protection of an organism, as well as in development of pathological reactions. We have studied the activity of kallikrein, kallikreinogen, angiotensine transforming enzyme, α1-protease inhibitor, and α2-macroglobulin in healthy children in different age periods, in newborns with hypoxic-ischemic encephalopathy, in children with infectious-inflammatory diseases of the urinary system, obesity, and metabolic syndrome.

The activity of the kallikrein-kinin system was increased in all the groups against the background of the decreased inhibitory activity of blood plasma of different intensity, which can be used for the prediction of the course of diseases.

We studied the quality of life of 115 patients with different genital prolapse degree before operative treatment in age of 35—71 years. Questionnaires Short Form 36 Health Quality Survey for research of neuter were used. We ascertained that quality of life made worse in all extents of prolapse and that quality of life lower with age.

100 pregnancy women at 13—30 weeks gestations were examined to study significance of connective tissue dysplasia in the development of cervical incompetence. Data of objective examination, anamnesis, physical examination. The role of connective tissue dysplasia was firmed by presence its markers, loss of weight, diseases with connective tissue dysplasia.

Medical-genetic study of the population of 5 rural districts of Buryatia Republic has been performed. The number of investigative population was 114,6 thousands people. The 23, 9 and 8 nosological forms of autosomal dominant, autosomal recessive and Xlinked diseases were revealed, respectively. The hereditary pathology spectrum and the features of prevalence in the studied population were described.

The aim of the investigation was to study the prevalence, clinical and prognostic values of polymorphism of genes II, V factors of blood coagulation and methylenetetrahydrofolate reductase in patients with chronic kidney disease. Examination was performed on 90 patients with diabetic nephropathy (DN) and 180 patients with chronic glomerulonephritis (CG). In addition to complete clinical and instrumental examination accepted in specialised clinic, with the help of polymerase chain reaction diagnostics of polymorphism of the referred above genes (samples of genomic DNA were obtained from peripheral blood leukocytes) was conducted. It was found that the protrombogenic mutations under investigation which are detected in patients with DN and CG more often than in healthy subjects are associated with development of hypercoagulation syndrome and higher risk of renal failure.

In this article the analisis of homeostatic status in 590 patients with puberty uterine bleeding has being presented. We found the following systemic changes in studies of erythron, hormonal status, immunity and tonus vegetative nervous system.

The one step study was aimed at assessing of GINA knowledge in primary care doctors. The results demonstrated that the primary care doctors most often use GINA (2006) as source of information. But some systematic problems were revealed. Among them there is shortage of primary care doctors knowledge about modern asthma treatment approaches and low level of diagnostic equipment in primary care.

The experience in teaching of doctors to using computer in course of medical and biological cybernetics at the faculty of professional skill SSMU is summarized. Characteristic properties of adult students are considered. The necessity of a special approach to teaching is proved. The method of composition and teaching of educational material takes into account a heterogeneity of groups and allows the students to get the needed skills.

Preparatory works on Design of electronic documents management system for SSMU Center of Postgraduate Education (CPE) were conducted. Workflow which accompany educational process of CPE students using tabular and graphic methods of information representation were described.

In the educational program of the Chair of Tuberculosis and Pulmonology of Siberian State Medical University (Tomsk), there is a special consideration towards tuberculosis alarm, the ways of TB detection, diagnostics and differential diagnostics of pulmonary and extra-pulmonary TB. Moreover, there is an educational promotion of deontology and medical ethics questions to students and listeners of the Advance Training Faculty and the Post-graduate Professional Education Course. They also participate in review conferences related to causes and ways of prevention medical malpractice cases.

The purpose of research was development of methods complex consecutive physiobalneotherapy a chronic prostatitis at participants of local conflicts. 83 participants of confrontations in the age of 23—37, with the verified diagnosis of a chronic abacterial prostatitis with an accompanying syndrome of vegetative dysfunction of a various orientation and a degree of expressiveness are surveyed and treated. Schemes of stage-by-stage rehabilitation have been developed for correction of poststressful infringements with purpose of base complexes at the first stage of regenerative treatment with addition at the second stage (with 7—10 days of treatment) local procedures. The lead comparative analysis of efficiency of medical actions specifies expediency of application consecutive rate of medical rehabilitation of participants of confrontations with the diagnosis of a chronic prostatitis.

Possibility of using administrative drug utilization database for pharmacoepidemiological monitoring is studied. The expediency of application ATC/DDD methodology for estimation tendencies in drug utilization in the system of preferential medicinal support is proved. It was determined more intensive use of combined asthma drug by patients of Tomsk, and oral corticosteroids and short-acting b2-agonists by patients from Tomsk region (without Tomsk).

The aim of the investigation was to study of features of сhronic kidney disease in patients with chronic opisthorchiasis (CO), psoriasis (Ps) and their combination. Examination was performed on 360 patients with CO, 100 patients with Ps, 50 patients with Ps combinated CO and 30 healthy subjects. In addition to complete clinical and instrumental examination accepted in specialised clinic, biopsy of kidney was conducted. The interrelation of intensity of sclerous processes in kidneys and renoprival syndrome with duration of CO and activity of Ps was found. Dehelmintization with biltricid promoted improvement of functional state of kidneys.

Open clinical comparative assessment of therapy effectiveness of depressive spectrum disorders was carried out. We compared patients who began treatment in special psychiatric department and those who underwent different consultations, investigations and took medication in primary care before hospitalization. This investigation showed high effectiveness of therapy, reduction of depressive symptoms, improving of psychological state and increasing level of social adaptation in patients who didn’t contact with primary care settings.

The article is based on long-term observation of 27 patients with West syndrome, age of onset, etiology of symptomatic forms, neurological status, efficiency of hormone therapy and antiepileptic drugs.

The purpose of research was studying vegetative reactance, a hormonal background, an exchange of cholesterol, a bioradical homeostasis and psychoemotional status at participants of confrontations and an opportunity of not medicamentous correction of their infringements. 109 employees of the power departments which are repeatedly taken part operations are surveyed and treated. Сomplex purpose of radonic baths and mm-wave therapy renders more expressed positive influence on fractions of cholesterol of blood, and purpose of pearl baths and galvanizing of area of a collar — on a hormonal background, a condition of a bioradical homeostasis)that can form the basis of the differentiated approach to regenerative treatment has been revealed.

The paper presents the results of clinical tests of the comparative estimation of tolerance, effectiveness and clinic-laboratory indices of chronic HBV and HCV patients Laifferon and Reaferon-ES treatment within a year (12 month). Less collateral effect caused by laifferon is stated. The results of effectiveness of Laifferon and Reaferon-ES treatment of the chronic HBV and HCV patients did not differ in compared groups.

In development of new treatment technologies, the reliability of results obtained should be beyond any doubts. The study of conjugacy of the obtained therapeutic effect with peculiarities of the combined treatment of patients with chronic cholecystitis in combination with chronic opistorhcosis and the revealing of predictors of the ultimate result are of great practical significance. The analysis of conjugacy tables and results of logistic regression, which allows one to determine prognostically significant signs (predictors) guaranteeing some or other result, favors the selection of the optimal treatment strategy for this category of patients.

The complexity of measures on detoxication of an organism is caused by the critical state of a patient against the background of multiple organ failure, disordered hemodynamics, pronounced changes of hemostasis, protein-energy deficiency, waterelectrolytic and acid-base disbalance. A new method is proposed for the treatment and control of the detoxication process. The positive effect of this method is caused by the syndrome-by-syndrome character of the therapy and the multilevel direction of the action. The proposed method involves all the interested organs and systems of an organism into the detoxication process.

Objective differential diagnosis inflammatory tuboovarian complex in patients hospitalized following emergency visit were investigated. We examined and operated 123 patients with acute abdomen symptom hospitalized at the inpatient gynecology department Regional Clinical Hospital following emergency visit.

A modern representations and opportunities of cellular technologies in cardiology and cardio surgery are summarized in article. Results of the clinical researches concerning an opportunity of participation stem cells in regeneration of a myocardium are summarized and analyzed. Results of own clinical researches devoted to studying of bearableness, safety and efficiency of different ways of delivery autologous mononuclear bone marrow cells to the damaged myocardium in patient with acute myocardial infarction are submitted.

The chronobiological approach was used to improve indices of functional activity of the biliary excretion system and enhance the general efficiency of treatment at chronic cholecystitis in combination with chronic opistorhcosis. For this purpose, transverse galvanization of the eigatric area was carried out against the background of general health-improving procedures and the YРА therapy by the background resonance radiator after intake of herbal remedy (hepatosol). The treatment was carried out with allowance for the individual phase of the rhythm of activity of the biliary excretion system or with the use of a group approach with procedures prescribed in the rising (from 10:00 to 11:00) or declining (from 13:00 to 14.00) phase of the rhythm. The results obtained indicated that the chronophysiotherapy in patients chronic cholecystitis in combination with chronic opistorhcosis increase the efficiency of treatment, while the accessibility of this approach confirms its practical significance.

In article to discuss diagnostic value of blood aggregate regulation system (BARS) and complexity of diagnostics, particularly, in critical state.Advantages and disadvantages of instrumental diagnostics technique were analyzed: thromboelastographia and lowfrequency piezoelectric hemocoagulographia of whole blood. Estimates new next-generation instrumental method of research - lowfrequency contact conductometry. This method permits to evaluate role blood plasma, cells hemostasis factors and wall of vessels in critical state BARS dysfunction.

Health of youth, is substantially defined by social factors, a way of life, an ecological situation, volume and quality of rendered medical aid. Ten years' dynamics (1999—2008) parameters of health trained youth of Tomsk and Tomsk Region characterized: growth of prevalence endocrinological pathologies on 20,9%, primary desease — on 46,8%. All this causes at a regional level to study structures endocrinological illnesses in view of influence of anthropogenous factors for realization of monitoring endocrinological health of youth.

789 industrial enterprise’s workers, having dangerous special conditions of work, were investigated by a questionnaire, containing 24 questions and statements about psychopathological symptoms. It was determined, that the risk factors of appearance of the psychopathological symptoms are a female sex, an age more than 40 years, a loss of spouse. The investigated factors of production (character, work experience, operating schedule, education) didn’t influenced on a frequency of appearance of the psychopathological symptoms.