The modern methods of monitoring of therapeutic and prophylactic application of antiaggregants, anticoagulants and thrombolytic agents have been examined. Their application allows to optimize the drug doses and prescription terms.

Here is presented the history of formation of the Tomsk microbiologists scientific school, biographies of the school organizers, teachers and researchers heading the microbiology chair in different periods of its existing. The ample archival materials have been used in the article.

There has been conducted a study of morphofunctional ovary changes at monopolar coagulation using histological, histochemical and ultra-microscopic techniques, and there have been evaluated hemorheologic factors and state of lipid peroxidation system (LPS) in postsurgical period. It has been proved that electrocoagulation stimulates the follicle growth for a short time but damages the generative and endocrine ovary apparatus and causes evident hemodynamic changes in perifocal zone. At the same time the raise of blood viscosity and erythrocyte aggregation and LPS activation are occurring. Possessing hemorheologic and antioxidant properties ascovertin produces a protective effect on generative ovary apparatus and microcirculation in it. 48 women after laparoscopic operations on ovaries with the use of electrocoagulation have been examined prospectively. The women of the basic group took the diquertin and ascorbic acid complex prior to and after the surgery in addition to the basic therapy. There has been made an evaluation of LPS factors prior to and after the surgery, computed kymopertubation results and hormonic state in a 1 month after the surgery, frequency of pregnancy beginning. Prescription of diquertin and ascorbic acid complex under the developed procedure is pathogenetically reasonable, it allows to increase the quality of treatment after laparoscopic operations on ovaries and encourages the preservation of reproductive function of a female organism.

Investigations of the mRNA expression of apoptosis intracellular regulators, bcl-2 and bcl-xL antagonists and bax, bcl-xL agonists of cellular destruction as well as mRNA expression of IL-5 were carried out. As a result of investigation of potential role of IL-5 in the regulation of programmable bcl-2-dependent destruction we found the increase of vitality and mRNA expression stimulation of bcl-2 peripheral blood eosinophils in patients with bronchial asthma (BA). It was found that fresh-isolated peripheral blood eosinophils in all investigated groups expressed bax and bcl-xL mRNA, bcl-xS had the less activity. In peripheric blood eosinophils of healthy donors the bcl-2 expression was not found, however, the increase of mRNA expression by IL-5 was shown in group of patients with bronchial asthma and, possibly connected with this, the appearance of bcl-2 activity. Thus, the decrease of apoptotic activity in peripheral blood eosinophils in patients with bronchial asthma may lead to the increase of eosinophil portion that is subjected to necrotic destruction and this may significantly contribute into bronchial asthma pathogenesis.

In the article there were discussed clinical and philosophical problems of general diagnostics theory — a fundamental discipline in clinical sciences study and doctor’s thinking. As a basic knowledge there were discussed the works of the biggest domestic physicians and philosophers whose world outlook positions have been united by dialectic problem of medicine study and, despite the test of time, have kept their actuality. Investigations of Tomsk scientists, the leading specialists in methodology and strategy of clinical diagnosis ascertainment, were underlined.

In the article the main point of conclusions by analogy as a kind of logical reasoning and their cognitive value are analyzed. The place of these conclusions in doctor’s thinking is examined. And a criticism of wrong evaluation of conclusions in the diagnosis theory is given.

130 criminal and civil cases had been maintained against physicians in Tomsk region within 1996—2002. There were pitfalls in diagnoses and wrong medical aid in 59 (45,4%) cases. Across diagnostic pitfalls, such as incomplete examination of patients, incomplete registration of laboratory results etc., there were methodological errors. It is known that diagnosis process proceeds in hypothesis form at all stages. While obtaining the history a physician is guided by suppositions arising during inquiring a patient. These suppositions are later verified in the process of an objective examination of the patient. Therefore the most frequent reasons of medical errors are the final diagnosis on the basis of the history and physicians’ inability to use the diagnostic suppositions while diagnosing at all stages. The majority of pitfalls has been made in diagnoses of appendicitis, stomach and duodenum perforated ulcer.

Ascertainment of disease symptoms is an extremely important stage in diagnostics process. Errors committed at this investigation stage may contribute in wrong interpretation of disease and inadequate treatment.

Current trends of social consciousness and of professional development of psychology in integrative human knowledge are analyzed in this article. Clinical psychology is considered as the field of psychological knowledge having important humanitarian and practical significance in joint development with clinical specialties in medical university.

The problem of peritonitis remains actual for practical medicine as the lethality and complications in this pathology are on a high level. General purulent peritonitis is the most dangerous one. This article covers the results of treatment of 52 patients with total peritonitis using our method. It causes the decrease of lethality up to 25%.

The goal of the investigation was to define whether conservative disinvagination would be safe and effective for long children’s intussusception.
368 children of 1 month to 13 years old age with intussusception have been treated in Novokuznetsk’ pediatric surgery clinic for a period from 1976 up to 2001. The number of boys was 248 (67,4%) and girls — 120 (32,6%) respectively. Patients of the age up to 1 year old were 185 (50,3%), older than 1 year — 183 (49,7%). 214 patients (58,2%) were hospitalized during the first
12 hours from the disease began, 71 patients (19,3%) — during 12—24 hours, 48 patients (13%) — during 24—48 hours, 35 patients (9,5%) — after 48 hours.
In our clinic the method of conservative intussusception therapy is considered to be the priority and its application, if there are no any abdominal cavity complications (peritonitis), does not depend on introducing form, patients’ age, time period of hospitalization following the disease or recurrence beginning. The bloodless therapy has been found to be effective: the 1th stage — 93,2%, the 2nd stage — 93%, the 3d stage — 86,4% and the 4th stage — 91,7%.
Thus, our facts earnestly prove both the potential of bloodless intussusception treatment method for children at late hospitalization (after 24 hours) and its safety and high efficiency (88,3%).

The goal of the present investigation is the study and assessment of taxation efficiency for pharmaceutical enterprises dealing with medicine retail.

As economic conditions have changed the system of medical aid management requires the development and realization of new methodological-organizing principles. At present stomatologic clinics are working in conditions of severe competition. This dictates the necessity to arrange their work more efficiently and to forecast the development of these or that situations. Modern stomatologic clinic or private dentist’s office should be considered as a unified complex that requires the efficient management and supervision. There is required a constant analysis of efficiency and a timely revealing of neglects and defects. It is also critical to analyze an activity of a clinic in various situations and to forecast the main activities for future.

The aim of this investigation is to assess variants of Epstein—Barr viral infection course in infectious mononucleosis nidus. There have been examined 5 groups of preschool institutions, in each there was found 1 case of typical infectious mononucleosis caused by Epstein—Barr virus. Total number of children under observation was 67: 5 children with typical (clinical) infectious mononucleosis and 62 children being in contact under the disease. Analyses of life history, clinical examination, peripheral blood examination, serologic marker spectrum of EBV- and HIV-infections and factors of immune system cellular component have been made during investigation. It was found that 1 child in a contact group was absolutely healthy, 53 children were virus carriers and 8 children had atypical infectious mononucleosis. Upon the investigation results the formation of infectious mononucleosis nidus has been proved and their peculiarities have been found.

In modern abdominal surgery purulent septic complications are the main reason of lethality in postoperative period. At the same time the problem of surgical suture reliability of large intestine remains very actual. Different methods of study of anastomosis physical containment (such as pneumo-, hydro-pressure, study of intestinal wall rupture force) are used for evaluation of the quality of formed anastomoses.
In literary review there is a comparative description of different methods of anastomosis mechanical solidity determination; the self-descriptiveness of these methods, their advantages and disadvantages are analyzed; questions of study of large intestine anastomosis elasticity are discussed.

Digital analysis potential of lumbar vertebra computed tomograms as a method of osteoporosis diagnostics has been investigated. Specific software designed for mineral weight and bone structure assessments has been developed. This software has been approved during the investigation of 10 lumbar vertebra anatomic preparations and 20 patients with chronic renal failure treated by hemodyalisis.
Result comparison of computed tomogram digital analysis, mineral structure investigation and histomorphometry of lumbar vertebra anatomic preparations showed that the developed method allowed to perform a reliable analysis of trabecular bone structure and indirect assessment of mineral density.

The aim is the study of EHF-therapy (extremely high frequency therapy) potential for the correction of microcirculatory injuries of patients with chronic generalized periodontitis in postsurgery period: in blood rheological properties and hemostasis system, change of oral fluid ability to coagulation. 42 patients have been examined and treated, including a complex periodontium examination: parodontal recess depth, stomatorrhagia at probing and gum capillary resistance. There have been determined a blood viscosity, erythrocyte aggregation, erythrocyte membrane deformability with rotation viscometer ABR-2; as well as activated partial thromboplastin time, prothrombin time, activity with coagulometer «Sola-Cey 2120» (Byelorussia) using reagents of «Tyekhnologiya-standart» company (Barnaul, Russia). An apparatus «Yavj-1» with wave-length of 5,6 mm with the exposure to biologically active face points (cv-26, cv-27, st-7, st-8) has been used for EHF-therapy.
There has been demonstrated that patients with chronic generalized periodontitis had blood rheological and coagulation properties disturbed, that accompanied with the increase of blood viscosity, erythrocyte aggregation, tissue prothrombinase activity and the decrease of blood antithrombin and anticoagulant activity.
Patients oral fluid components intensify the disturbances in blood rheological properties due to erythrocyte aggregation increase, and at the same time increase the blood coagulation potential. EHF-therapy recovers the blood rheological properties (its viscosity) more effectively, erythrocyte ability to aggregation and hemostasis system factors in comparison with the traditional treatment.

The aim of the study is the evaluation of the significance of various risk factors for congenital fetus pathology (congenital defect – CD) and the development of risk numeric scale. 424 pregnant women with fetus CD and 520 pregnant women with fetus without congenital defects have been examined. Artificial neural nets have been used for investigation how various factors effect on pregnancy termination. It has been found that the important factors for congenital fetus defect risk are: age younger 18 years of an pregnant women, age older 35 years, noncarring of pregnancy in anamnesis, complicated clinical course of the first pregnancy trimester, CD cases in a family, ultrasonic markers of chromosome pathology in the first pregnancy trimester. Changes in maternal serum AFP, hCG and uE3 levels and blood flow disorders are important to forming high risk group. A numeric scale for CD risk has been developed on the basis of neuronic net analysis.

In this article there is presented the information about the first Siberian Bacteriological Institute, it history, role and traditions. Names and biographies of the creators of this medical institution are given.

In the article it is presented the biography of the outstanding Russian scientist-clinician, physician, professor of Siberian State Medical University, head of therapeutics chair of the faculty of raising the level of skill and postdiploma training, honoured doctor of Russia E.I. Beloborodova.