The purpose of this study is to understand the relationships in the mother-placenta-child system in case of hematogenous thrombophilia and thrombotic state of readiness in pregnant women.

Materials and methods. The research group consisted of 454 patients, was divided into two subgroups: the 1st subgroup included 225 women (pregnant and, subsequently, obstetric patients) and the 2nd subgroup included their 229 infants who were in the perinatal center of State Novosibirsk Regional Clinical Hospital. At 3–5 days of life 75 newborns from the 2nd sub-group underwent hemostatic system assessment. 42 healthy newborns from somatically healthy mothers (without thrombophilia) were included in the control group. The assessment of their hemostatic system was carried out to determine the performance of reference values.

Results. The relationships between the health condition of newborns and hemostatic system disorders in mothers with thrombotic state of readiness, hematogenous thrombophilia, and morphohistological changes in the placenta were studied. The researchers analyzed labour and delivery records, pathomorphological examination of a placenta, neonatal records, and assessed the hemostatic system. A number of complications were detected during a gestational process and an early neonatal period. The correlation analysis has established a relationship in the mother – placenta – child system in a number of factors affecting children’s health outcomes. To correct above mentioned abnormalities preventive measures can be taken. They allow to avert the development of perinatal complications in case of hematogenous thrombophilia and (or) thrombotic readiness.

The purpose of this study is to estimate Ex vivo physicochemical and biological features of three-dimensional (3D) biodegradable matrices “polylactic acid/calcium phosphates” (hereafter 3D composites) designed with the help of additive technologies (3D printing) as potential materials for bone tissue regeneration.

Materials and methods. Experimental samples (disks 1,2–1,6 mm thick, and 11 mm or 8 mm in diameter) of composite biodegradable 3D matrices (hereafter 3D composites) have been produced from initial mixture of 95 mas% polylactic acid (PLA) and 5 mas% hydroxyapatite (HAP). Computer-aided design method, Blender software and fused filament fabrication (FFF; fiber diameter 1,75 mm) with 3D printing were used in sample production. 100 mas% PLA disks served as control. One of the sample surfaces was textured with 0,3–0,5 mm wide grooves. Physicochemical properties of 11 mm disks (geometry, mass, morphology, roughness, electrostatic voltage, surface wettability, and element composition) were studied. Biological trials included the evaluation of 24-hour cytotoxicity of 8 mm samples in culture of mononuclear leukocytes of a healthy volunteer or human Jurkat T cell leukemia-derived cell line (hereafter Jurkat T cells). Moreover, osteogenic potential of 11 mm disks was determined in 21-day culture of human adipose-derived multipotent mesenchymal stem cells (AMMSCs) be means of osteocalcin secretion and intercellular matrix mineralization visualized by alizarin red S staining.

Results. The features of PLA-HAP 3D composites generated by 3D printing correspond to physicochemical parameters which are crucial for bone tissue recovery. In case of small amount of calcium and phosphorus they facilitated ex vivo mineralization of extracellular matrix formed in AMMSCs culture. The number of died (by necrosis, mainly) leukemic Jurkat T cells but not mononuclear leukocytes of a health volunteer increased to 9–10% in 24-hour in vitro contact with PLA-HAP 3D composites unlike PLA samples alone.

Conclusion. Polar reaction of tumor and normal cells to PLA-HAP samples in case of increasing amount of calcium phosphates in 3D-composite may be valuable for the development of new materials used for osteosynthesis of fractures and endoprosthesis in patients with hematological malignancies.

The purpose of this paper is to compare the results of immunological tests (tests with recombinant allergen TB in standard dilution (RAT) and the Mantoux tuberculin test) in children at risk of developing tuberculosis in Tomsk Region.

Materials and methods. A retrospective analysis of 1204 outpatient medical records of children and adolescents at the age from 1 to 16 was performed.

Results. When two tests are carried out at the same time (skin test with RAT (Diaskin-test) and Mantoux tuberculin test), the proportion of positive reactions to tuberculin was 92,4%, including 6,6% of hyperergic reactions, while there were 6,0% of positive reactions to RAT, including 3,2% of hyperergic reactions. The biggest number of positive reactions to RAT was recorded among children with severe and hyperergic tuberculin sensitivity (28,7%) and children from tuberculosis prevalence areas (17,5%). The lowest number of positive reactions to RAT was recorded among children with conversion of tubercular tests and children with latent TB infection (LTBI) – 2,8% and 1,5% respectively.

Conclusions. The results of skin tests with RAT as compared to the tests with tuberculin are different. When there is a conversion of tubercular test the positive reaction to Diaskintest was detected only in a few cases (2,8% of cases) as compared to prevailing (in 96,4% of cases) positive reaction to tuberculin; in children with severe and hyperergic results the tuberculin reaction to RAT was the same in every third child (28,7%); in children with increasing sensitivity to tuberculin the immunological response during Diaskintest was detected in 4,7% of cases.

More often local forms of tuberculosis were detected among children with hyperergic reactions to skin tests with RAT (12 of 38 children, 31,6%), χ2 = 306,3; p <0,001, and when there is an overlap of hyperergic results of two immunological tests (6 of 15 children, 40,0%) χ2 = 303,5; p <0,001

The purpose of this paper is to improve the accuracy of X-ray diagnostics of circular-shaped growth (CSG) by developing computed tomographic semiotics of qualitative characteristics of its surface and the state of the surrounding bronchi using target 3D-reconstruction.

Material and methods. 560 patients at the age of 3–89 years were examined. Target 3D reconstruction was carried out with the use of 3D Fly Through program (Toshiba Medical Systems, Japan) which removed the tissue surrounding CSG at a distance of 5–10 mm from the outer boundaries.

CSG was inscribed into a cube. In case of the primary central and peripheral lung cancer a number of patients with severe rough surface of CSG prevailed over a number of patients with slightly rough surface was detected. In case of infiltrative tuberculosis, pneumonia, echinococcus, retention cysts the prevalence of a number of patients with slightly rough surface of CSG over a number of patients with rough surface was identified. In case of single cancer metastases, single and multiple tuberculomas the prevalence of a number of patients with non-uniform smooth surface of CSG over a number of patients with uniform smooth surface was identified. In case of multiple cancer metastasis, focal tuberculosis, cysticercosis the prevalence of a number of patients with a uniform smooth surface of CSG over a number of patients with uneven smooth surface was identified. In case of benign tumors, eosinophilic infiltrate, gamartohondroma, aspergilloma, chronic abscess, intrapulmonary hematoma there was not difference between the number of patients with a uniform smooth surface of CSG and a number of patients with uneven smooth surface. In case of primary lung cancer metastasis, single and multiple tuberkulomas, echinococcus, cysticercosis there was a prevalence of the number of patients with expressed deformed bronchi surrounding CSL over a number of patients with moderately deformed bronchi. In case of infiltrative and focal tuberculosis there was prevalence of a number of patients with moderately deformed bronchi surrounding CSL over a number of patients with expressed deformed bronchi.

Results. In case of pneumonia, benign tumors, retention cysts, gamartohondroma, aspergilloma, chronic abscesses, and intrapulmonary hematomas there was no difference between the number of patients with expressed deformed bronchi surrounding CSL, and a number of patients with moderately deformed bronchi. Patients with single and multiple metastases, eosinophilic infiltration, bronchi surrounding CSL were not changed. It is necessary to develop a software that allows quantitatively characterize the surface of CSL and the degree of deformation of the surrounding bronchi.

Aims. Alzheimer’s disease is a multifactorial neurodegenerative disease characterized by the presence of amyloid beta peptide containing plaques, and neurofibrillary tangles. Beta-amyloid is a major risk factor and it plays a central role in the onset and progression of Alzheimer’s disease. However, question of the influence of beta-amyloid on neurogenesis in the hippocampus in the adult brain is still open. The purpose of this paper is to study cognitive functions and their association with proliferation, survival and migration of newly-formed cells in normal adult rat brain and in the experimental Alzheimer’s disease.

Materials and methods. Rats (Wistar, males, 7 months) were used. Experimental group (Alzheimer’s disease model with the intrahippocampal administration of beta-amyloid 1-42 (5 µl) bilaterally in the CA1 area) and a control group (sham-operated animals with the intrahippocampal administration of Phosphate buffered salin (5 µl) bilaterally in the CA1) have been tested. The study was conducted from February to July. Neurobehavioral test (Morris water maze) was used to assess working memory and memory consolidation. The study of cell migration was performed by introducing bromodeoxyuridine (50 mg/kg). Expression of neurogenesis markers in the subgranular zone of the dentate gyrus of the hippocampus was studied has been studied with indirect immunohistochemistry for free-floating sections followed by the confocal microscopy.

Results. Modelling of Alzheimer’s disease leads to impaired cognitive function and memory in animals. We found that these events were associated with the suppression of proliferative (р = 0,043) and migratory activity of brain cells (р = 0,031), but not survival of cells (p = 0,985) compared to the control group.Training in Morris water maze of animals with experimental Alzheimer’s disease promotes migration of progenitor cells along the rostral migration way (р = 0,011) compared with the group without training. However, the number of neuroblasts (р = 0,809) and proliferation of neuronal progenitor cells (p = 0,083) were not significantly affected compared with the group without training.

Conclusions. Decreased level of brain cells proliferation, alterations in their migration and development of cognitive dysfunction have been found in the rat model of Alzheimer’s disease, thus suggesting impairment of neurogenesis induced by amyloid. Possible involvement of local insulin resistance into the development of neurogenesis alterations is discussed.

The purpose of this paper is to study the most common non-motor symptoms of the Parkinson’s disease (PD): olfactory dysfunction, constipation and associated with them variety of fecal microorganisms in patients with Parkinson’s disease.

Materials and methods. We studied olfactory function in 51 patients with PD using Sniffin Sticks Test and taxonomic composition of fecal microbiota.

Results. Olfactory dysfunctions (hyposmia, anosmia) were found in most patients that participated in study as well as differences in alpha-variety of gut microbiota among groups with different olfactory characteristics.

Conclusion. Our findings suggest that the composition of gut microbiota must be associated with etiology and pathogenesis of PD.

The purpose of the study is to assess the possibility of applying the integrated module as the basis of a celltissue equivalent for treatment of wounds of skin and soft tissues. In the frame of the set task the following problems were being solved: research of the spatial structure and architectonics of the surface of the developed base collagen-containing materials and their biocompatibility with cell cultures.

Materials and methods. The study of a material which is a two-layer complex film, consisting of collagen and polysaccharide components was carried out. The collagen was separated from the dermis and was then impregnated with particulate demineralized bone matrix (DCM) according to the original methodology. For the purposes of the study the dehydrated material was created in the form of a film. Electron microscopic examination of surfaces was performed on scanning electron microscope JEOL JSM-IT300LV in high vacuum and at low values of probe current (< 0,1 nА). Studies to assess the viability of the cells cultivated on films of collagen material (tested for cytotoxicity and the adhesive capacity) were performed in vitro using strains of diploid human fibroblasts 4–6 passage. The culture condition was visually assessed using an inverted Leica microscope DM IL (Carl Zeiss, Austria), equipped with a computerizes program of control of culture growth (Leica IM 1000).

Results. The data obtained in the study of the surface structure of the developed complex module showed that it seems to be promising as a basic component of the cellular-tissue system with its large number of structural formations for fixation of the cells and a well-organized barrier layer capable of vapor - permeability. Experiments in vitro confirmed the absence of toxicity of the material being studied in relation to the culture of dermal human fibroblasts, suggesting the possibility of creation on its basis of cell-tissue complex and further experimental studies in vivo.

Conclusion. Thus it was experimentally confirmed that the physical characteristics of the developed integrated module satisfy the requirements for the materials for cultivation of cells. The absence of cytotoxicity on the model of a culture of dermal human fibroblasts allows to make a conclusion about a possibility of its use as the basis of cell-tissue equivalent. Preliminary results indicate the advisability of further experiments in vivo aimed at improving complex collagen-containing materials, the development of different ways of their application and clinical evaluation of the effectiveness in the treatment of wounds of various genesis.

The purpose of this paper is to identify genetic factors connected with personal features using the panel of 12 polymorphic markers associated with the risk of developing dementia in patients with Alzheimer’s disease, schizophrenia and alcoholism.

Materials and methods. The correlation among quantitative traits of personality, temperament and character determined with Cattell’s (the Sixteen personality factor questionnaire (16PF)), Leonhard-Schmieschek’s, Spielberger-Khanin’s, and Eysenck’s (IQ) tests were analyzed with polymorphic variants of 12 genes involved in the development of severe mental disorders such as alcoholism, schizophrenia and Alzheimer’s disease. DNA samples of 150 students were genotyped using PCR-RPLF method. The data were processed by nonparametric statistical methods.

Results. Interallelic nonrandom associations in paired combinations of GABRA2-PICALM, PICALMADCY3, CLU-CBX7 and CLU-ADCY3 polymorphisms were detected. This may indicate the adaptive selection influencing the maintenance of behavioral homeostasis in population. A number of statistically significant associations of genetic variation were found: CLU with perfectionism(Q3) of 16PF and the exaltation of the Leonhard’s tests, PICALM with tension (Q4) of 16PF and the imbalance of Leonhard’s tests, DISC1 with vigilance(L) of 16PF, and exaltation, cyclothymia of Leonhard’s tests, ZNF804A with imbalance by Leonhard’s test, SLC6A4 with reasoning(B) of 16PF test, ADCY3 with self-reliance(Q2) and extraversion(F2) of 16PF test, MIR9-2 emotional stability(C), liveliness(F), social boldness(H), extraversion(F2) of 16PF, and dysthymia, hyperthymia of Leonhard’s tests, with the personal anxiety of Spielberger-Khanin’s test, CBX7 with vigilance(L), warmth(A) of 16PF test, SLC6A3 with IQ.

Conclusion. These findings support the idea of overlapping genetic component in common mental and neurological disorders and variability of human cognitive and personality traits.

Purpose: this study morphological changes the exorbital lacrimal glands at experimental impact on an organ of vision of high-intensity light.

Material and methods. White not purebred rats males (n = 40) were subjected to continuous influence of light intensity by 3500 lx within 1, 7, 14 and 30 days, the control group (n = 10) contained in conditions of natural lighting (20 lx). Exorbital lacrimal glands fixed in formalin, embedded in paraffin wax, stained hematoxylin-eosine. By means of an oculary insert of Avtandilov counted specific volumes of output channels, an epithelium, stroma and vessels of exorbital lacrimal glands, defined an epitelio/stroma ratio. The analysis of data was carried out by methods of descriptive statistics with calculation of a median (Ме) and interquartile range (Q1 –Q3). For an assessment of distinctions used nonparametric criterion of Mann – Whitney.

Results. In 1 days in response to high-intensity light influence there is a reflex strengthening of synthetic function of exorbital lacrimal glands. For the 7th days the first signs of violation of functioning with development of hydropic dystrophy in the lacrimacytes appear. By 14th days fibrous changes develop, in a glandular parenchyma harderization sites appear. For the 30th days the nuclear pycnosis of separate lacrimacit, accumulation of a lipofuscin in cytoplasm is observed.

Conclusion. The obtained data allow to estimate in dynamics compensatory and adaptive reactions of lacrimal gland in response to high-intensity light influence from the moment of the beginning of their development before emergence of the first signs of a decompensation.

The purpose of this work is to study the influence of extracellular ATP (adenosine-3-phosphate), which is an activator of purinergic receptors, on contractive activity of rat aortic ring segments precontracted by α1-adrenoreceptors activation with phenylephrine and evaluate the impact of potassium channels of plasma membrane on mechanisms of ATP activity.

Material and methods. Contractive activity of vascular smooth muscle cells was studied using the method of Organ Bath Myography applied to the thoracic aorta segments in male Wistar rats both with intact and removed endothelium. ATP (1–1000 mM) produced a dose-dependent relaxing effect on intact and endothelium-denuded segments precontracted with phenilephrine. To assess the impact of potassium channels on mechanisms of ATP activity we used tetraethylammonium (10 mM), a nonselective potassium-channel blocker, glibenclamide (10 mM), the blocker of ATP-sensitive potassium channels and 4-aminopiridine, a blocker of voltage-gated potassium channels.

Conclusion. Our study has shown that the impact of ATP on segments with intact endothelium depends on the ATP-sensitive potassium channels whereas the impact of ATP on endothelium-denuded aortic segments depends on both ATP-sensitive and voltage-gated potassium channels. 

Currently the role of microbiota in diseases pathogenesis, its therapeutic and diagnostic potential are of the utmost interest for scientists and medical doctors. Parkinson’s disease is neurodegenerative disorder for which microbiota’s dysbiosis was previously shown.

The main goal of the study is to compare the colon microbiota composition in case of Parkinson’s disease and other neurological pathologies, including idiopathic familial dystonia, essential tremor, multiple sclerosis, multiple system atrophy in order to determine the intestinal flora landscape specific to Parkinson’s disease.

Material and methods. One hundred twenty-six patients, 93 with Parkinson’s disease and 33 with other neurological pathology were examined. For all patients, physical examination and fecal samples collection were performed. Microbiota taxonomic composition was analyzed by sequencing of bacterial 16S rRNA genes followed by bioinformatic and statistical analysis.

As a result of the study, significant differences between groups in microbiota composition were found. Gut microbiota of patients with Parkinson’s disease was characterized by increase of Desulfovibrio piger, Lactobacillus mucosae, Yokenella regensburgei, Alistipes indistinctus, Oscillospira capillosus, Clostridium bolteae, Soleaferrea massiliensis, Butyricimonas virosa, Dorea massiliensis, Victivallis vadensis abundances. Patients with other neurological diseases had increased levels of bacteria belonging to Blautia, Intestinibacter, Coprococcus genera and Anoxystipes fissicatena, Fusobacterium periodonticum, Gemmiger formicilis, Papillibacter cinnamivorans, Roseburia faecis, Lachnoclostridium indolis, Clostridium populeti, Clostridium tertium, Roseburia intestinalis, Eubacterium desmolans, Eubacterium cylindroides, Clostridium clariflavum, Eubacterium eligens, Coprococcus eutactus, Intestinibacter bartlettii species in their gut microbiota.

Consequently, gut microbiota in case of Parkinson’s disease was different from the microbiota of patients with other neurological diseases, including neuroinflammatory and neurodegenerative disorders, in terms of taxonomic diversity and composition. 

Purpose. To study the functional state of the diaphragm in patients with chronic obstructive pulmonary disease (COPD) complicated by chronic hypoxemia.

Materials and methods. The study included 90 patients with COPD III–IV stages, group D (GOLD, 2015): 45 patients with chronic hypoxemia and 45 normoxemic patients. The following parameters were analyzed: spirometric level, oxygen saturation and arterial blood oxygen, breathlessness (by the Modified British Medical Research Council Questionnaire), rate of COPD exacerbations. Ultrasound examination of the diaphragm was conducted.

Investigations were carried out twice: at baseline and after 12 months of observation. All patients with chronic hypoxemia were prescribed long-term oxygen therapy (LTOT).

Results. The study of functional indicators in COPD patients revealed that the presence of hypoxemia was characterized, as compared with normoxemic patients, not only by more severe breathlessness and airflow limitation, but the alteration of diaphragmatic function. LTOT appointment in hypoxemic patients was accompanied in a year by changes in the functional state of the diaphragm (increase in relaxation rate of the diaphragm during quiet breathing) and a reduction in the number of COPD exacerbations.

Conclusion. The shift in diaphragm function could mediate the positive impact of LTOT on COPD prognosis, including the number of COPD exacerbations in patients with hypoxemia. 

Parkinson’s disease (PD) is a neurodegenerative disorder with a complex pathogenesis. Today more and more studies are focusing on microbiota-gut-brain axis searching the causes of neurodegenerative and neuroinflammatory processes.

The aim of our study is to determine the relationship between the composition of gut microbiota and clinical manifestations of PD.

Materials and methods. We examined 89 patients with a PD diagnosis. Clinical assessment was performed including medical history collection, rating disease stage using Hoehn and Yahr scale. Motor and nonmotor symptoms as well as possible complication were examined using the Unified Parkinson’s Disease Rating Scale. In addition, patients were asked to fill in Parkinson’s Well-Being Map and defecation diary that included Bristol scale. DNA isolation was performed in accordance with the method described. Preparation of libraries and amplicon sequencing of marker variable region V3–V4 of bacterial 16S rRNA genes was performed with MiSeq device (Illumina, USA) according to manufacturer’s standard protocol. Filtering readings by quality and their taxonomic classification were carried out using QIIME version 1.9.0 software. The assessment of statistical differences in abundance of taxonomic units among the groups of patients was performed using IBM SPSS Statistics 23.1 software.

As a result, we have identified significant differences in the abundance of seven genera among the groups of patients with different forms of the disease. We identified about 40 genera constituting 54.8% of the intestinal microbiota, that had a correlation with the clinical manifestations of the disease. These microorganisms might be involved in the pathogenesis of PD and, thus, require more clinical research in the light of emerging new methods of altering microbiotic composition by correcting dysbiosis to improve disease management and outcome. 

The purpose of this paper is to perform the pilot review of the official medical statistics on reported Opisthorchis felineus (O. felineus) infection and liver and intrahepatic bile duct cancer in Russian Federation, covering the period 2011–2013.

Materials and methods. Statistical data collected from 81 regions of Russia, reflecting the incidence of opisthorchiasis over a period from the 1st of January 2011 to the 31st of December 2013 was analyzed. The analysis of official health statistics of malignant hepatic lesions and intrahepatic bile duct was conducted in 82 regions of Russia over the same period. The data was obtained from the annual reports of the Russian center of information technologies and epidemiological studies in the field of oncology.

Results. The average annual incidence of O. felineus was 24,7 ± 9,0 cases per 100,000 population. The highest incidence was observed in Khanty-Mansiysk Autonomous Okrug, Yamalo-Nenets Autonomous Okrug, Tyumen Oblast, Tomsk Oblast, Omsk Oblast and Novosibirsk Oblast. We did not observe any significant change in O. felineus infection rates within last 20 years. However, we found that infection incidence had increased in some geographical units of Western Siberia. The incidence of liver and intrahepatic bile duct cancers was 4,8 ± 0,2 cases per 100,000 population; the highest rate was reported in Far East regions, Siberia and Volgograd Oblast. This study documents the importance of opisthorchiasis in certain endemic areas and presents the best available data on associations between O. felineus infection and liver/intrahepatic bile duct cancers in endemic areas of Russian Federation.

The purpose of this study is to evaluate the ability of systemic glucocorticosteroids administered during the exacerbation of the disease to have a modifying effect on the qualitative and quantitative composition of the oropharyngeal microbiota.

Material and methods. The study included 88 patients with COPD and 50 patients with stable asthma. The patients have had a history of observation for twelve months or more; they are characterized by the absence of exacerbations and systemic antibiotic therapy for four weeks or more prior to inclusion in the study. Also, all patients participating in the study were taken samples of oropharyngeal microbiota for isolating bacterial DNA and sequencing 16S rRNA gene sequences followed by the analysis of the taxonomic composition of the microbiota. Generalized linear model implemented in the R programming language version 3.1.0, glm2 package was used to identify the relationship between taxonomic composition of metagenomes and metadata.

Results. The study suggests that the use of systemic glucocorticosteroids administered during the exacerbation of asthma and COPD modifies the composition of the respiratory microbiome in the period of stability increasing the oropharyngeal representation of non-pathogenic bacteria such as Bacteroidetes (including members of the genus Prevotella) and reducing bacterial contamination of oropharyngeal swabs by proteobacteria especially Streptococcus, and Haemophilus, which includes pathogens.

The article provides an overview of scientific research to explain the mechanisms of inefficient implementation of antigen-specific immune response in patients with tuberculosis infection depending on the clinical form (infiltrative and disseminated pulmonary tuberculosis) and the course (drug-sensitive and drug-resistant pulmonary tuberculosis) of the disease. The mechanisms of immune imbalance in patients with pulmonary tuberculosis are associated with abnormal co-stimulation of a signal required for the activation of T-lymphocytes and immunosuppressive influence of regulatory T-cells both when they interact with dendritic cells at the inductive stage of the immune response, and in the process of differentiation and proliferation of effector cells with formation of suppressive mode of immune-regulation.

Cowden syndrome is a rare genetic disorder caused by the abnormal development of all three germ layers. Taking into consideration the mesodermal origin of mesenchymal tissue that gives rise to the vascular system, the pathology of cerebral blood vessels can occur in conjunction with this disease and cause the development of cerebrovascular disease in such patients.

A subdestructive cooling of osteonecrosis of femoral head in children with Perthes disease (II) followed by activation of reparative processes in bone tissue was performed. It ensured the functional recovery of supporting limb capacity, reduced rehabilitation period by 23%, and improved the quality of patients’ life. Simultaneous biostimulating operation of tunneling and cryotherapy in management of necrotized femoral head is operation of choice for children with Perthes disease.

The article presents the analysis of the creative heritage of the outstanding physician, teacher, scientist, Academician of the USSR Academy of Medical Sciences D.D. Yablokov in connection with the 120th anniversary of his birth.