To ascertain the severity of opium-induced liver injury for chronic viral hepatitis C (HCV) patients with detection of morphological characters of hepatocyte impact by opiates.

Needle biopsy of liver and the light microscopy of biopsy material were made both for isolated HCV and HCV+opiomania patients.

Liver injury (hepatitis activity, fibrosis stage) for HCV patients against the background of opiomania does not differ from the case of isolated HCV. Use of alcohol by opium addicts even in very small doses (10—15 g per day) cause the development of significantly more severe liver injury. Fibrosis of central vein was found significantly more often for HCV against the background of opiomania.

Fibrosis of central vein is a differential-diagnostic criterion of being opiates as an etiological factor of liver injury. Opiates as an isolated toxic factor does not cause severe liver injury for HCV patients unlike the use of alcohol even in small doses.

The results of 77 M. tuberculosis clinical isolates genetic typing, allocated from patients with extensive destructive infiltrative and disseminated pulmonary tuberculosis are presented in the article. It is established that among genetically non-uniform Mycobacterium tuberculosis strains, circulating in Tomsk and the Tomsk Region, and causing acute progressive destructive pulmonary tuberculosis, 19% show multi drag resistance. Beijing family strains make 27% from the general population, have a high clusterization index (74%), level of their multi drag resistance in 3 times exceeds that at «not Beijing» strains for which the share of clustering strains makes 11%.

Mandibular defect experimental endografting has been performed with the use of composite TiNi-based materials. An ability to create the artificial alive biological models was proved to act high-efficiently in the mandible perpetually. When designing the reconstructive mandibular models made of TiNi-based material for longlife usage it’s to be complied thoroughly the methodology and technology of individual approach. Experimental research results are recommended for investigation and application when creating anthropological mandibular models in the wide clinical practice.

The aim was to investigate the electroencephalography indexes dynamic caused by neurofeedback in athletes. The main results are that the neurobiofeedback cumulative effect on the electroencephalographic indexes in the high qualified athletes with the dominance of metabolic modulation of heart rate variability is carried out. The conclusions are that the interlobar reciprocal actions reorganization in a brain and the general changing of quantitative electroencephalogram indexes of all standard diapasons of frequency are revealed both in the locus of biofeedback control and overall brain convex surface.

The aim of the investigation was studying sodium pyrophosphate’s effect on experimental oxalate nephrolithiasis.

Experimental nephrolithiasis modeling by using of 1% ethylenglycole’s solution as a drink for rats during 6 weeks. First group was control. In the second group since the third week was being administrated sodium pyrophosphate in dose 2 g/kg. Was detecting parameters of kidney’s function, markers enzymes activity, was carried out morphological researches.

It was concluded that sodium pyrophosphate’s therapy reduce experimental oxalate nephrolithiasis.

In the experiment in vivo the mechanisms of the development of inflammatory regenerative processes with corneal ulcer against the background of the instillations of blood autologous mononuclear leukocyte and traditional pharmacotherapy are studied. It is determined that against the background of the use of blood autologous mononuclear leukocyte the duration and the intensity of inflammation reduce and the clearance of ulcer defect from necrotic mass accelerates. The instillations of blood autologous mononuclear leukocyte against the background of traditional pharmacotherapy of experimental corneal ulcer stimulate fast change of cell phases in the inflammation center and activate the process of regeneration of damaged cornea structures.

The purpose of this investigation is to the estimate influence of composition dihydroquercertin and lipoic acid on lymphatic flow, capillary filtration and blood viscosity in comparison with effects of individual components. Lymphokinetic activity of dihydroquercertin was detected. Capillary-protective effect, but in less degree lymphokinetic and hemorheologic ones of composition are higher than the effect of its separate components.

Aim of the study was to investigate the levels of individual subpopulations of T-regulatory (T-reg) cells in patients with different phenotypes of chronic obstructive pulmonary disease (COPD) with moderate bronchial asthma and healthy volunteers. COPD was associated with increased level of natural (CD4+CD25high) T-cells, while emphysematous phenotype of disease was associated with the highest pool of natural CD4+CD25high. Bronchial asthma was associated with low levels of inducible (CD4+ FoxP3+ ) T-reg.

The concentrations of matrix metalloproteinases (MMP-2, -3, -9) and their tissue inhibitors (TIMP-1, -2) were studied in blood serum of 193 patients with squamous cell head and neck carcinoma (SCHNC) and in 38 healthy donors using immunoenzymatic assay. The decreased MMP-3 and TIMP-1, -2 levels were found in patients with oral cavity tumors as compared to patients with laryngeal cancer. The serum MMP-9 and TIMP-1 levels were significantly higher in head and neck cancer patients than in healthy subjects. High TIMP-1 and MMP-9 levels in blood serum of patients with SCHNC should be greatly attended for detection of their predictive and prognostic significances.

Experts of the RPU «Microgene», developed the new domestic medication for prevention of rubella — The rubella vaccine cultural live, on the basis of the vaccine strain RA 27/3. After the safety of vaccine had been proved on laboratory animals, the clinical trial had been activated on volunteers.

The first phase of trial had been carried out on the women at the age of 18—25.

After introduction of medications (vaccine or production strain of vaccine) the volunteers had been observed during 42 days. Blood and urine sampling had been executed till vaccination and 28 days later after introduction of medications.

Results of trial presented safety, low reactogenicity and evident immunologic properties of medications. It permitted to start the next phase of the clinical trial on the basis of children’s volunteers.

The aim of this study was to evaluate the impact of TNFα and their receptor in autoimmune diabetes. It was found the most pronounced inhibition of production of soluble forms of the receptor for TNFα in the background of an increased number of lymphocytes bearing membrane-associated receptors for TNFα in patients with manifested variant of diabetes type 1, compared to patients with latent autoimmune diabetes of adults.

In experiments on rats with Walker-256 carcinosarcoma the ability of water-soluble polysaccharides from Tussilago farfara and Acorus calamus influence on efficiency antineoplastic therapy and hepatotoxicity investigated. Polysaccharides reduce a level of liver enzymes in blood serum of rats at cyclophosphamide damaged liver, as well as increase the antimetastatic effect of cytostatics. Water-soluble polysaccharides from Acorus calamus restore most efficiently biochemical disturbances at cyclophosphamide intoxication.

Investigation of the indices, characterizing a functional condition of the hemostasis in patients with peritonitis, to takes more reliable trend forecasting a development of the multiorgans insufficiency syndrome and unfavorable outcome of the disease, tran research of hemodynamic and autointoxication states.

At present argon enhanced coagulation is widely used to handle the gallbladder in laparoscopic cholecystectomy, which may lead to worsening intraabdominal hypertension, increasing the risk of postoperative complications. When analyzing the results of surgical treatment of patients operated concerning cholelithiasis with use of various techniques, it was found that the argon enhanced coagulation provides a reliable hemo-and cholestasis, reduces the duration of the operation, although it may increase the risk of adverse effects.

Contact conductometry reflects changes in the functional state of the hemostatic system and provides the highly reliable information about the functional interaction of all chains of the hemocoagulation cascade as a whole.

The aim of comparative research was the estimation of alarm and depression dynamics at patients with stable chronic obstructive pulmonary disease under influence of tiotropium treatment on HADS questionnaire. Are surveyed 30 patients who were not receiving supporting therapy and 27 patients, using a fluticasone/salmeterol combination. After 3 months of tiotropium treatment the level of alarm and depression decreased in both groups.

It is proved in the article to decide studying of bases of theory of diagnostic on pediatric faculty, that allow problem development and formation clinical thinking irrespective of quantity of hours of internal diseases released for teaching.

In the review questions of pathogenesis of acute upper urinary tract`s obstruction are considered. The critical analysis of existing theories of upper urinary tract`s motor activity carried out. The basis mechanisms of pathogenesis — disturbs of urodynamic and pathological renovascular changes are described.

On a thyroid disease conservative correction background, preoperative period is accompanied by the upcoming surgery risk and its optimal level assessment, as well as assessment of specific complications development possibilities. Typically, the thyreopathies pathogenesis is accompanied by the thyroid gland functional activity disorder, which provides variety and, in some cases, the clinical picture similarity. Also, due to metabolic processes endocrine regulation fail in the whole organism, it causes disorders development in various organs and systems. Each thyreopathy is characterized by the relevant homeostasis indicators and clinical finding, in the development of which, the role of thyroid gland hormone production variant (hypothyroidism, hyperthyroidism, euthyroidism) and the deviation intensity level are not significant only as a pathological process marker, but also determine the compensation of an adaptive disorder tactics in pre- and postoperative period.

Keratodermias can be isolated or can be a part of syndromes typical for other dermatological deceases. Investigation of clinical effectiveness of Kartalin liniment in complex therapy of palmar-plantar keratodermias was held with a group of 26 patients with different clinical variants of the deceases. Besides local treatment, the patients got systematic therapy corresponding to the standards of medical treatment for each nogological form.

For estimation of clinical effectiveness of the suggested complex of general and local arrangements there was done a calculation of the number of days spent in hospital white curing keratodermias. This showing made up 23 days in the examined group and positive clinical dynamics in the control group has been noticeable sense 33,7 day.

It is on record that the curved and hooked acromion types result in the lesion in the rotator cuff tendons. Research aim: to increase the informational content of ultrasound investigation of a glenohumeral joint using ultrasonic analysis of acromial morphology. To research is based on the comparison of radiographic findings of the acromion with the length of coraco-acromial ligament. Altogether 112 patients aged from 21 to 80 which complained the shoulder pain were examined. Among them there were 76 (67,9%) women and 36 (32,1%) men.

The length of the coracoacromial ligament was defined for each type of acromion process.

Conclusion: we found ultrasound equivalent (the length of coracoacromial ligament) for each type of acromion, which allows to reduce radiation exposure of the patients while their examination.

Study objective is clinical use of a stent of flat over-elastic element with the effect of elastic recovery — nikelid-titanium of TH-10 make in case of occlusive diseases of main arteries. Hybrid approach has been used, that is femoropopliteal shunting with stenting of deep artery of thigh with the construction of nikelid-titanium ТН-10. In pre-surgical and post-surgical periods malleolarbrachial index Charcot's syndrome, life quality of the sick Charcot's were studied. The used methods improves blood supply of a limb by 31 percent according to the clinical parameters, in comparison with the control set. In recent and distant post-surgical periods there was no complications found.

Inspection of 89 patients on a hemodialysis for the purpose of studying of feature hemostasiogram's indicators depending on level гомоцистеина is spent. At patients on a hemodialysis activation of intravascular curling of the blood, the most expressed at patients with hyperhomocysteinemia is revealed. Interrelation existence between concentration of homocysteine and hemostasiogram's indicators noted.

At treatment of patients with multidrug-resistant tuberculosis of lungs on scheme of the program DOTS-PLUS was noted development that or other side reaction on the part of organs and systems. We studied temper, frequency of the development of side effect upon upshot of the treatment beside by 101 patients in process of stationary course of the treatment.

The aim and task of the study were to improve the method of wave-current sinusoscopy and to develop the algorithm of compex treatment of acute odontogenic maxillary sinusitis with concomitant pathology of intranasal structures abnormalities. 106 patients with acute and chronic odontogenic maxillary sinusitis were examined. The improved method of wave-current sinusoscopy allows with high level of significance to diagnose in the maxillary sinus not only exudates and side-wall hyperplasia, but artificial bodies — according to the value of wave-current sinusoscopy equal to (247 ± 74) Hz. Including this method to the treatmentdiagnostic algorithm helps to improve treatment of the patients with odontogenic maxillar sinusitis.

The results of cryosurgical treatment of 339 patients with various focal liver diseases are presented. The experience of using cryosurgical equipment designed and manufactured in the Tomsk Hepatological Center in the surgery of focal liver diseases is analyzed. The application of inventive instruments in the liver resection leads to a decrease in the intraoperative blood loss down to 30- 40% and favors the reduction of backsets, because the cryodestruction of liver stump after resection leads to the destruction of rest parts of parasitic tissue in the surgical zone. The use of cryosurgical techniques lowers the number of deaths down to 4.42%.

We studied 57 patients with acute myocardial infarction (AMI) aged 20 to 63 years. Initially (day 25 from disease onset), Fibroblast growth factor (FGF), osteoprotegerin, vascular endothelial growth factor (VEGF-A), von Willebrand factor (vWF) were determined in patients’ blood by immunoenzyme method; hemostasis system was examined. The control group consisted of 15 healthy volunteers aged 19 to 50 years. The patients were divided into two groups: the major group was receiving Trombovazim in dosage 800 mg per day during 1 month together with the standard therapy of AMI, and the control group, which was receiving no Trombovazim. Control study of the dynamics of FGF, osteoprotegerin, VEGF-A, vWF, and hemostasis hemostasis parameters was performed after 1 month of treatment with Trombovazim. The inclusion of Trombovazim into the complex therapy of AMI was found to result in a decrease in FGF, osteoprotegerin, and VEGF-A levels due to the endothelial protection effect and apoptosis control.

The parameters of vascular-platelet and coagulation hemostasis components had no significant changes.

In the clinical practice, an increase in the efficiency of combined treatment of employable patients with biliary system diseases working under adverse conditions and having chronic stress and neurosis is very urgent. The use of drug-free treatment including antistress measures is justified. Tentative results are indicative of the positive effect of this approach on the functionnal state of biliary system organs with reduction of neurosis and state anxiety and with increase in the index of psychological weightness.

Using methods of factorial analysis the values of the main components (MC) defining a condition of various links of immune system in patients with urgent surgical pathology are calculated. MC interrelations with clinical characteristics describe qualitative structure of the factors influencing the organization of immune system indicators. Results of research can be used for forecasting of diseases current and a choice of effective tactics of treatment.

The aim of the research was to determine how chronic obstructive lung disease clinical signs with lung ventilation function disturbance to various degrees correspond to respiration biomechanics and high resolution computed tomography indices. It was revealed that respiration biomechanics indices are changed at the early stages of chronic obstructive lung disease formation.

A statistical study of indicators of primary and chronic morbidity, mortality, clinical examinations, emergency care, the level of hospitalization of patients with asthma in the Tomsk Region for the years 1998—2008 was performed. This study used data of 843 thousand inhabitants of the Tomsk Region in the age of 18 years.

During 1998—2008 in the Tomsk Region has made significant progress in the conduct of asthmatic patients, which is reflected in the cost of health care and higher quality care this patient.

In article the historical foreshortening of formation of school pathophisiological in Siberia is presented. The contribution to its development of one of leaders Siberian pathophisiological professors Pavel Petrovich Avrorov from the date of which birth in 2010 140 years were executed is considered. Its short review scientific, educational, medical and public work is given. The short estimation is given its basic proceedings.

Viktor Ivanovich Tikhonov (to the 70 th birthday).