An investigation of in vitro and in vivo reaction of adenocarcinoma cells in conditions of direct contact with composites designed in a base of phospholipid concentrate, cisplatin and nanoparticles (diameter less than 10 nm) of iron capsulated by carbonic coating was the aim of paper. Their antitumor effect has been established to be conditioned by direct cytotoxic relatively elective action on malignant cell and, on the other hand, by stimulation of tumor node fibrosis. Proposed biotechnological approach that used low doses of cytostatic drug (1/10 LD50) and nanoferromagnetic particles (2 mg/kg) may be useful to design magnetocontrollable regimes for regional immuno(bio)therapy of cancer and its metastases.

On long-term introduction to rats in dosage 100 mg/kg polyphenol complexes from heartwood and callus culture of Maackia amurensis Rupr. et Maxim. had a marked influence on the activity of free radical oxidation. Under conditions of induced oxidant stress both polyphenol complexes inhibited prooxidant activity directly affecting the products of free radical oxidation. Inhibiting influence on the production of oxygen active forms that is characteristic for both phytocomplexes is determined by inhibition of mechanisms both enzymatic and non-enzymatic defense.

For detection of cytokine production features in patients with development of chronic tick-borne borreliosis the evaluation of spontaneous, fitohaemagglutinin-stimulated and stimulated with antigen of borrelia cytokine production was conducted in supernatants of three-day blood cells cultures. High risk of development of chronic tick-borne borreliosis associated with intensive spontaneous and antigen-stimulated production of interferon-g and transforming growing factor-β1 in acute disease.

Owing to shortcomings of existing methods of evaluation of oral cavity microflora, reviewed possibilities for this purpose of new noninvasive method — laser optical-acoustic spectroscopy. The results show perspectivities of this method for diagnosis of microflora disorders.

Night lighting and microwave exposure have been influence on structures of stress realization. The endocrine, fotoperiodical and adaptive functions of rodent submandibular salivary glands belonging to hormone produced duct cells. To evaluate their morphofunctional state at guinea-pigs and rats using the methods of light and electron microscopy there have been analyzed striated and granular ducts. It has been revealed that instant and twenty-four-hour strengthening of duct cell stress induced secretory activity was similar. It is concluded that salivary glands take part in circadian expectations to stress.

An investigation for a possible acute toxicity of the complex of water-soluble polysaccharides (WSPS) extracted from calamus root (Acorus calamus L.) has been performed. No toxic effect has been observed on the organisms of experimental animals after a twofold intragastric, subcutaneous, and intravenous introduction of the highest maximum dose of the WSPS being investigated. The results of the experiments did not allow detecting the average fatal dose (LD50) of the WSPS being investigated as no deaths among the experimental animals had been observed. The obtained data lead to the conclusion that the WSPS of calamus root are to be added to Substance Hazard Class IV (low hazard substances) in compliance with State Standard GOST 12.1.007-76.

The aim of this work was to assess the lymphocyte transformating responses to stimulation with antigens or mitogens in chronic opisthorchiasis patients with low and high degrees of infection intensity. The heavily infected patients demonstrated the lowest levels of stimulated lymphocyte transformating response in vitro, and CD8+ or CD16+ counts in peripheral blood.

The reason of increase apoptosis in sincythiotrophoblast is suppression of activity ATP-ase, moving phosphatydilserin on an external membrane sincythiotrophoblast, and increase of quantity annexin V in homogenate placentae.

For evaluation of the maximum values of the hemoglobin compensated by means of the appearing additional cell’s flaw into peripheral blood the method of mathematical modeling has been used.

Tissues of apical granulomas at the exacerbation and remission stages before and after the treatment with the use of transcanal electrogranulotomy (TCEGT) have been studied by the methods of histological and clinical X-ray investigations and nonparametric statistics. The content of polymorphonuclear leukocytes at the exacerbation doubled compared to the remission (p < 0,05). After the treatment at the exacerbation stage (87 teeth) and beyond it (116 teeth), the activation of macrophages and fibroblasts was observed, as well as the appearance of Malassez's epithelial rests. The reconstruction of the bone structure has been found by the X-ray investigation in 97,6% of patients in the period up to 5 years. The treatment of granulomatous periodontitis with TCEGT is possible at any stage.

Physical pretraining of 102 Wistar rats during 30 days altered the reactions of haemostasis system to one-day hypobaric hypoxia. Decreased level of thrombinemia, ameliorated platelete, and plasma hаemostasis, increased anticoagulation, and fibrinolytic activity were observed. These changes were more pronounced in the experimental group of animals having experienced intensive physical training.

Daily monitoring arterial pressure (DMAP) and definition endotehelin 1-21 immunofermentat a method was perfermed in 79 children and teenagers with type 1 diabetes mellitus (DM1) in the age 10—18 years, with duration of disease 2—16 years auskultative a method on the apparate “Shiller BR-102 plus” (Switzerland). Depending on a degree of expressiveness diabetic nephropathy (DN) patients have been distributed on three groups: 1st — normalalbuminuria (n = 31), 2nd — microalbumiuria (n = 32), 3rd — proteinuria (n = 16) and 16 person the control group comparable on a floor and age. At children and teenagers with DM1 according to DMAP, attributes of a labile arterial hypertension (AH), met at 34,1%, stable at 25,5%. Frequency of revealing of stable forms АГ depend on expressiveness DN. The daily rhythm the AP at patients DM1 was characterized by a low degree of night decrease the AP. 47,1% patients 1st groups, 72,7% patients 2nd and 75% patients 3rd had no adequate decrease the AP at night. Communication between the raised level endotehelin 1-21 with development and progressing diabetic nephropathy, and also with indicators diastolic AP is revealed.

Delayed care of pelvic inflammatory disease as a risk factor for impaired fertility.

The review devotes to studying the role of cytokines in development of autoimmune diabetes mellitus, latent autoimmune diabetes in adults included. Therapeutic approaches to prevent the loss of endogenous insulin secretion are discussed. There is review of clinical trials of immunosuppressive agents and modulators of immune tolerance in autoimmune diabetes mellitus.

The historical review of the treatment of the injuries of the main arteries has been carried out by the author from the XVII century to the our time. The prime stages of the formations of the reconstructive surgery of the arteries have been shown.

The article is presented with the results of comparing assessment of clinical efficiency of the magnetic-laser therapy in doublefrequency ranges (150 ang 1 500 Hz) combined with iron therapy (sorbifer 100 mg once a day) in treatment of benign anemia of pregnancy, running above with the chronic gastritis, associated with contamination of gastrointestinal tract by Helicobacter pylori. The results of treatment show that the clinical effect is optimal for noninvasive magnetic-laser impact on blood with 150 Hz frequency. This method allows to raise hemoglobin while maintaining the iron depot in the form of ferritin together with cutting off the infectious process on the gastrointestinal tract mucous.

Children and the teenagers suffering СD of 1 type, despite of spent therapeutic actions, training in «School of a diabetes», not always reach full indemnification СD. The lead complex of psychological inspection of 200 children and teenagers with a diabetes of 1 type in the age of from 5 till 17 years with duration of disease from 1 year till 13 years. The control group has been presented by 150 healthy contempoparies comparable on a floor, to age, a place of residing and not having chronic diseases. As a result of carried out research psychological features of the person which influence adaptation to disease, efficiency of achievement of the harmonious attitude to illness and definitions of therapeutic strategy of treatment at various stages of evolution of disease. In process of progressing a diabetes personal specificity decreases, symptoms ригидности, emotional flatness, apathy accrue.

The generalized information in area of noncardiac complications prevention are introduced based on results of own researches and literature data (prevention of ischemic stroke, gastroduodenal bleeding and infectious complications in cardiovascular surgery): preparing of patient for planning surgical intervention, including finding of stenosing and/or embolodangerous plaques and theirs surgical treatment; diagnosis of gastroduodenal erosions and ulcers, theirs epitelization and etiologic treatment; diagnosis and sanation of infectious focuses; using of surgical methods of cerebral protection (puncture intravasal grafting, intravasal filters) and pharmacologic cerebroprotection (nimodipine, vinpocetine) in operations on the brachiocefal artheries; two-step using of proton pump inhibitors more than three weeks duration in patients in groups of risk of gastroduodenal bleeding; prevention of infectious complications using three antibacterial drugs (cefalosporine of the third generation, rifampicine and fluconasole) mainly in cardiac surgery with on-pump circulation. Using the suggested arrangements, according our research data and results of investigations, fulfilled in other scientific centers, lets fundamentally decrease the frequency of aforenamed complications and increase the surviving of patients after cardiac and vascular surgery.

On the grounds of analysis results of the congenital clubfoot’s treatments 120 children of the first year old the indications and contraindications to correction of the deformation by the soft redressmentory bandage were determinated, the particularities of their using were distinguished. The designed method raises the good results of the conservative treatment of the disease more then on 30% in contrast with the traditional methods. The efficiency correction of the congenital clubfoot by the soft bandage straightly depends on observance particularities of the repair of the deformation by the offered way.

In the paper organization of nonfinancial incentives for pharmacists were analyzed and improvement references in staff management were designed. Through the comparative investigation of pharmaceutical specialists’ encouragements it was found that pharmaceutical enterprises practise some of and not always regular nonfinancial incentives where limited list of encouragements is included. Integration of factor and cluster analyses and further two-dimentional data analysis found no correlation between applied encouragements system and pharmacists needs that resulted in essential job motivation weakening. Nonfinancial methods preference is in lesser financial load that is why their application area much wider than in financial methods. In the event that complex application of pecuniary and non-pecuniary job stimulation methods a synergetic effect producing sizable working efficiency rise has been found.

The role of the alcoholic factor in structure of death rate of the population of Tomsk area is studied. At pathology-anatomic research alcohol in blood was found out in 38,9% of cases. This parameter remains rather stable during of some years while death rate from a poisoning with ethyl spirit last three years has decreased almost on third. The given parameter speaks about essential underestimation of the alcoholic factor in structure of death rate. At carrying out of examinations and researches of corpses of nonviolent death ethyl spirit has been found out in 18,4%. These data draw attention to alchohol-dependent diseases of internal bodies. Other picture comes to light at the analysis of the alcoholic factor in structure of violent death rate. For 2007 at carrying out of examinations and researches of corpses of a violent death ethyl spirit has been found out in 63,2% of cases. The greatest contribution of the alcoholic factor is revealed at such reasons of death, as a poisoning with carbonic oxide (69,7%), action of low temperatures (67,4%), road and transport incidents (48,5%).

Methodic approaches to the prediction of a positive corporate image of pharmaceutical organizations are presented. A technique is developed for the prediction of a risk of loss of the corporate image. The technique includes the algorithm for construction of estimation and prediction tables and rules of their usage.

The position that the agreement on the rendering of paid medical services to people (physical persons) is a public agreement is justified. The public agreement differs in its legal order of performance from the ordinary agreement on the paid rendering of (medical) services. The writing form and handling procedures of this agreement are also different.

Medical economic efficiency of various schemes of rehabilitation of 120 children with chronic gastroduodenitis is studied. The Most economic scheme of rehabilitation of children with chronic gastroduodenitis is the scheme with use of training of children in gastroschool. Sanatorium treatment considerably raises mediko-economic efficiency of rehabilitation actions.

Optimal concentrations of the magnetite and stanum dioxide nanopowders for production of a stable aerosol are determined. The dependence of laser radiation absorption by the aerosol on the nanomaterial concentration in the initial solution is revealed.

The problem of full-featured, high-efficiency replacement of the heart’s pumping ability with an artificial analog is urgent all over the world. The most promising model of an implanted artificial heart is now the model with the elecrohydraulic principle of operation. In the weight and overall dimensions and in the efficiency, this model can compete with the most popular Abiokor model of the artificial heart.

To study psychophysiological characteristics of young schoolchildren in the learning dynamics under the conditions of healthsafe learning process, 104 children of 1st to 4th classes were investigated. It has been found that in most young schoolchildren, the moderate extraversion, medium level of emotional tolerance, moderate general anxiety, and low physiological resistance to stress prevail among psychophysiological characteristics. At the end of the school year, children are characterized by the decreased efficiency, signs of chronic overwork, decreased positive emotions, and decreased adaptability. The most pronounced negative changes are characteristic of 4th -clss children, which is likely connected with the transition to the new stage of learning.

This study presents historical information about pharmacy beginning, formation, development in one of the most severe and remote from the center regions of Russia. There is retrospective mention of pharmacists and chemists contributed to the basis and up-to-date system of medicine supplying of population in boundless territory former Yakutsk Region — Sakha Republic (Yakutia).