Considering the necessity to study the problems of propaedeutics of clinical medicine, besides the well-know syndromes by which the clinical diagnosis is formed, there are nosological syndromes of tiredness in which the changes of inner and outer environment are taken into account:

1) non-liminal outer ecology,

2) endoecological syndrom of tiredness,

3) coagulopathy,

4) syndrom of custom.

Diagnostics of these syndromes makes it possible to form a new clinical diagnosis taking into account the changes of inner and outer environment which lead to genetic default and endoecology phenomenon.

In this lecture there is the information about historical steps of fundamental researches of pathogenesis of atherosclerosis, about biochemical, immunological and genetic abnormalities. Significance of x-ray, radionuclide methods in diagnosis of vascular affection is shown. The achievements of nowadays in the methods of treatment and prophylaxis of atherosclerosis are presented. Author’s own original synthetical classification of atherosclerosis is suggested.

The materials focused on formation and development of pathological physiology department at one of the oldest medical institutes in West Siberia are available in the article. The main trends of scientific research and the results of bringing elaborations into public health practice are described. The authors report base and clinical pathological physiology teaching peculiarities and enumerate text-books published by members of the department staff. The paper is a brief review of former members of the department staff who have placed at the head of scientific research institutes, pathological physiology departments in different cities of Russia afterwards.

Mechanographical method helped to investigate retractive reactions of unstriped muscle оf auriferous ways at bronchial asthma in the experiment that guinea-pigs had. Sensitization of guinea-pigs by ovalbumin leads to the development of hypersensibility to inhalation of this protein with external characteristics of abnormality of bronchial patency. This process is followed by decomposition of epithelium of bronchi, development of immune inflammation in bronchial wall and hypertrophy of muscle layer. In sensibilized beings there was observed the development of hype reactivity of unstriped muscles of auriferous ways on histamine. It appears in histamine of liminal concentration and increasing of maximal amplitude of contraction. Reactions on choline ergine and β2-adrenergine effect didn't change.

The aim of the work is to study the condition of the local immunity of stomach when there is bronchial asthma and the role of affection of some its factors in the formation of gastro duodenal pathology in this category of patients. 302 patients, both male and female were examined in the age of 18—60 with exogenous and mixed bronchial asthma. Gastro duodenal zone of all patients and local immunity of stomach in 65 patients were examined. The condition of the local immunity of the stomach was evaluated according to the content of secretory antibody A (sIgA), antibody G (IgG), circling immune complexes, activity of lysozyme in stomachic secretion. 68 patients (22,5%) have erosive affections of gastro duodenal zone. It is revealed that pathology of gastro duodenal zone is developed with the local deficit sIgA and rise of the content IgG in stomachic secretion. Dose-dependent effect of the long term peroral therapy by the systematic glucocorticosteroids at bronchial asthma on the pathology of gastro duodenal zone and local immunity of the stomach is revealed. Lowering the content of IgG and circling immune complexes in stomachic secretion and immune complex reactions in mucous membrane of the stomach, physiological doses lower the frequency of erosive affections of gastro duodenal zone. Treatment by supraphysiological doses of systematic glucocorticosteroids brings on disruption of specific protection section in mucous membrane of the stomach. It leads to the rise of erosive affections of gastro duodenal zone in this category of patients. Revealed affections of the local humoral immunity of the stomach in the patients have general characteristics and one-directed character of changes with the local immunity of respiratory tract when there is bronchial asthma. It gives the opportunity to suppose the participation of immune system of mucous membrane when having bronchial asthma.

The principals of creation and activity of Coordinational council of the young scientists in Siberian State Medical University are presented. The organizational structure and the main activities of Coordinational council of the young scientists in SSMU are shown.

There are presented in the article the main ideas of professor I.N. Osipov, that are stated in his monographs, dedicated to the issues of diagnosis. It was described the further development of this ideas in the work of Child Diseases’ Department of the SSMU.

A diagnosis, as a type of getting knowledge (alongside with science and education) goes from consequences to a reason (from symptoms to nosological unit), this determines it’s hypothetical character. There is a choice amongst variants, exposed by method of differential diagnosis, which is been realized on the ground of logical operations of moving out hypothesises and constructing analogies. Though a diagnosis don’t carries a new knowledge, it presents a creative process, which is been understood as carring out the essential human sorces in their full realization (the basic creative law).

The Authors do the attempt to understand and explain, what image a physician in complex clinical situation puts the diagnosis of disease, which it does not know. Such possible if physician speculates on clinical picture. It is offerred differentiate the notions «knowledges» and «cogitations of physician».

The cogitations of physician exceed the volume of concrete its knowledges (including reference literature) due to presentation and imagination, which allow to build the diagnostic hypothesises and goal-directed to lead searching for new  for itself knowledges in process of checking the hypothesises. The development of ability to speculate on clinical picture provide the knowledges:

1. General and private semiology.

2. Characteristics an symptoms, syndromes, diagnosis.

3. The main laws of logic, философии and the general pathology.

Allegorizes and is motivated the judgement that study of theory of diagnostics promotes the development of ability to speculate the clinical thinking on clinical picture and active shaping.

192 consecutive patients with chronic pancreatitis against the background of chronic opisthorchious invasion were observed from 1970 to 2000 years in the Tomsk region hepatological center (female — 117 (60,9%), male — 75 (39,1%)). 166 (86,5%) patients were treated therapeutically (anti-fermentative, analgesic, anti-spasmodic drugs drugs, and substitution fermentative therapy). 26 of them (13,5%) were incapable of improvement. Preoperative diagnostic is based on detection specific peculiarities of chronic opisthorchiоs pancreatitis on the background of opisthorchiоs invasion. Original classification of the chronic opistorchious pancreatitis was suggested. Specific developed surgical tactic allows distinguishing the best radicalism of operations, to warn appearance of specific complications.

The aim of the study was to estimate the influence of rehabilitation measures on physical growth and cognitive functions in preschool children.

We examined 224 children from 4 to 7 years old and in 197 (88%) of them revealed high level of health deviations. The most frequent were cervical insufficiency and bearing abnormality, of general and delicate motions, speech abnormalities. All children underwent cognitive functions checkup. In this connection we tilled the complex of rehabilitation measures for the children with physical growth and cognitive functions abnormalities. The efficacy of rehabilitation measures was estimated 3 years later.

The clinical observation of 12-year-old patient with sarcoidosis is described. This disease is extremely rare in children. Initially pneumonia was diagnosed in a boy, then the necessity of conducting of differential diagnostics between sarcoidosis and tuberculosis was appeared. The final diagnosis-sarcoidosis of lungs was diagnosed on the basis of comprehensive clinical and laboratory examination taking into account focus-infiltrative changes in lungs, intoxication, involvement of T-immunity system and also revealing of granulomas by morphological study of biopsy material, having distinctive characteristics typical for sarcoidosis.

To determine the role of exogenic and endogenic factors in chronic obstructive pulmonary disease (COPD) forming 100 patients (50 patients are control group) were examined by means of clinical and genealogical researches, including family tree composition with analisis of 3—4 generations, genotyping on the most wide-spread α1-proteinase inhibitor (α1-PI) gene alleles (M, S, Z), definition of the α1-PI level in the serum. The role of exogenic factors (smoking, pollutants) have been confirmed in COPD forming, while primery α1-PI deficiency have been revealed only in 6% COPD patients. Therefore, further investigations of other genetic alleles in COPD patients are necessary.

Oxygen concentration before and after oxygenation and relaxation time were determined by the method of cathodic voltammetry in infusion solutions, such as physiologic solution — 0.9% NaCl, Ringer-Locc’s solution, glucose — 10%, poliglucin, haemodes, oxigenated by 5 athm. pressure.

There were given the recommendations for practical usage of oxigenated infusical solutions.The most optimal solutions for the oxygenotherapy are physiologic solution and poliglucin. 12 patients with bronchial asthma were treated with these solutions successfully.

The qualitative and quantitative aspects of microbiological diagnosis of tuberculosis from 1996 to 2001 in Altay region are presented. In the process of realization of regional complex program «Fighting with tuberculosis» the positive dynamics of microscopy. The improvement of material technical basis of laboratory service, modern equipment, staff training helped in this process.

For more effectiveness of pelvic inflamatory desease treatment there were observed 61 patients with different forms of this patology and saggested a new complex method of treatment, including the usage of magnetolazer therapy after endoscopical organokeeping operations in early after operation period. The dynamics of proinflamation citokins change content (interleikin-1 beta and alfa tumor necrosis factor) in blood serum of patients with pelvic inflamatory desease confirmed the effectiveness of magnetolazer therapy. Resalts of the invesnigation proved that saggested complex method of treatment for patients with pelvic inflamatory desease allows to make organokeeping operations for reproductive women and to improve results of treatment.

The history of development of medical service and preparation of medical staff in the territory of Tomsk region is presented. The first hospitals of Tomsk are listed, the names of their establishers are underlined.

In the article there are introduced the history of forensic medicinе department, the names of its grounders, the key events of the scientific life of the department, the prospects of its development are introduced.

In the present work the information about roentgens of skull bones at women of fertile period with polycystosis of ovaries and hypoactivity of thyroid gland is presented. It is revealed that more frequently met rontgenologic factors at patients with this pathology are small turkish saddle, narrowing of entrance in turkish saddle, endocraniosos and craniostenosis.

Application of marketing approaches in the Scientific Medical Library of the SSMU. The use of additional financial assets for library development. Informational and promotional activities. Library work on the formation and perfection of the image.

In the article the creative biography of great Russian scientist, professor of Siberian State Medical University, director of scientific research institute of gastroenterology G.K. Zherlov.