Substance for investigation serve patient with locally-associated epilepsy (LAE), taking antiepileptic drugs — 151 men. From them — 73 patients with drug-resistant forms of the disease and 78 patients with control epileptic seizure. Spend monitoring indicators of EEG during sleep and wakefulness cycle. In the group of patients with drug-resistant forms LAE significantly detected more frequently epileptiform activity and increase index α-rhythm during sleep in comparison with period wakefulness.

On the original experimental model of autoimmune oophoritis the stages of formation and extent of destruction to structural elements of the ovary were studied, using histological and histochemical methods, the content antiovarian antibodies in the serum of experimental animals by enzyme immunoassay was determined. Autoimmune oophoritis is the step-wise character, with a gradual increase in the pathological process, which is manifested in the growth of mononuclear infiltration, restructuring steroid-producing structures, destruction of oocytes.

The aim of the investigation was studying vicasole’s effect on experimental oxalate nephrolithiasis.

Experimental nephrolithiasis was being modeled by using of 1% ethylenglycole’s solution as a drink for rats during 6 weeks. First group was control. In the second group since the third week was being administrated vicasole in dose 500 mkg/kg. Was being detected parameters of kidney’s function, markers enzymes activity and free oxygen’s radicals activity, was carried out morphological researches.

It was concluded that vicasole’s therapy reduce experimental oxalate nephrolithiasis

A peculiarity of the congenital syphilis of recent years is an increase of the number of cases of latent forms of the disease, marked with osteopathy. With the help of an examination of 50 children with early congenital syphilis, the following ultrasonic signs of a musculoskeletal system lesion were revealed: osteochondritis 90%, osteosclerosis 80%, and periostitis 30%.

The comparison of the nature of a musculoskeletal system lesion with serological data of the specific process activity showed that complex manifestations of lesions with periostitis being a component were of the greatest clinical significance.

The effect of nanosecond pulses of X-ray (pulse repetition rate of 8—22 pulses per second, dose 0,3—1,8 mR per pulse) on the functional activity of isolated mitochondria of mice liver. The effects of changing the rate of oxygen consumption by mitochondria in different metabolic states of Chance and the degree of coupling of oxidation and phosphorylation were investigated. That effect depends on the parameters of exposure.

The data of the comparative analysis of separate parameters of cell and humoral chains of immune response in patients suffering from pulmonary tuberculosis accompanied by eosinophilia has been presented in the article.

With involving contemporary immunological methods of research, it has been stated that tuberculosis infection in combination with eosinophilic blood reaction is accompanied by marked cytokine imbalance, characterized by increase in the concentration of IL-5 (mediator with anti-inflammatory activity) in blood serum against the background of low serum level of the key anti-tuberculosis cytokine — IFN-γ.

The research of unsaturated and saturated of fatty acids (UFAand SFA) in the erythrocytes in men and women with chronic ischemic heart disease was done by the method of a gas-liquid chromatography-mass spectrometry before and after simvastatin intake. Increase in the ratio of ω3 / ω6 FA at the expence of reducing of the rate of ω6 UFAwas revealed  in men after treatment for 2 months which is the condition for the changing of type of synthesized eicosanoids. The decrease in the total content of ω6 and ω9 UFAled to the fall in the amount of the UFAin both sexes, despite of the heightened rate of amount of ω7 UFAin women. The treatment led to the increasing of saturated FA amount (SFA) and it led to the decrease of unsaturation index FA on the back of the reduction of nonsaturated fatty acids level (NFA). The results confirm the presence of lipid-lowering effect of Simvastatin, but there is a need for therapy, taking into account of the normalization of the exchange FA in patients with chronic coronary ischemic heart disease.

This study investigates the contractile activity of smooth muscle segments of guinea pig pulmonary artery by the method of mechanografy and morphological picture of lungs, airways and blood vessels of the pulmonary circulation under the influence of nanosized magnetite. It is shown that chronic inhalation intake of magnetite nanoparticles has a cytotoxic effect, leading to inflammatory changes in the airways, lung parenchyma and pulmonary vessels, as well as a change in contractile activity of the pulmonary artery by the action of neurotransmitters and mediators of exercising their functions under physiological conditions or produced during the inflammatory the process.

We have examined 36 liquidators (participants in emergency clean-up after the Chernobylnuclear accident) many years after the external γ-irradiation (on average (143.0 ± 14.0) mGy for (3.3 ± 0.8) months) and 13 workers of a typical research nuclear reactor, who were subject to chronic external γ-irradiation (on average (78.40 ± 12.21) mGy for (13.1 ± 2.2) years). The level of metabolites of lipid peroxidation (conjugated diene and triene conjugates of lipid hydroperoxides, TBA-reactive products) and the activity of catalase, superoxide dismutase, 5'-nucleotidase in blood serum were determined; changes in vessels of microcirculatory bloodstream (MCB) in skin-muscle bioptate were analyzed. Under the action of small doses of ionizing radiation, the oxidative disbalance and changes in activity of 5'-nucleotidase in blood serum сaccompanying the systematic inflammatory alteration of MCB vessels were found.

Latent inhibition phenomenon indexes the ability to ignore irrelevant stimuli. Disturbance of latent inhibition is registered in different psychiatric populations with pathology in the emotional and cognitive spheres. In our experiments latent inhibition was measured in a conditioned passive avoidance reaction in rats that previously received 0 or 20 conditioned stimuli exposures followed by foot shock. Latent inhibition was disrupted in high-anxiety rats and pathologically enhanced in low-anxiety rats. The effects of an agonist (muscimol) and an antagonist (biсuсulline) of GABA_A receptors on the learning and latent inhibition in these rats were studied. In high-anxiety rats, muscimol (1 mg/kg) had no effect on learning but enhanced latent inhibition. Biсuсulline (1 mg/kg) enhanced both acquisition of the reflex and latent inhibition in low-anxiety rats. The present results show direct involvement of GABA_A-receptors in process of attentional inhibition to irrelevant information.

This article presents the results of experimental research of nanostructured track membranes implantation as drainage for refractory glaucoma surgery. For nanostructuring of the membrane surface was applied a treatment by air plasma. Tissues reaction of rabbit’s eyes to drainage implantation was studied in the experiment in vivo. The histological research data demonstrate that the reaction of the inflammatory cells to drainage was minimal. After antiglaucomatous operation filtering blebs were split and plane and in all the cases resulted in a stable hypotensive effect.

Problem of diagnosis and treatment of patients with necrotizing pancreatitis is an urgent. So it is interesting to study the effectiveness of a multicomponent antihypoxant and antioxidant cytoflavin to reduce violations of the detoxifying properties of the liver in experimental pancreatitis and reduce the severity of pancreatic endotoxemia. Pancreatic modeled by introducing into the pancreas of autobile in a dose of 0,15 ml/kg. Cytoflavin was injected into animals of a comparison group in a dose 0,21 ml/kg in
5 minutes after the model of pancreatic necrosis. We determined the activity of enzymes: alanine transaminase, amylase, and gamma glutamyltransferase, the content of direct bilirubin, glucose, and urea. After modeling of pancreatic necrosis in two days, there are signs of acute liver failure, as evidenced by the differences in the studied parameters of blood and hepatic portal vein: increased alanine transaminase and gamma glutamyltransferase, the change in concentration of metabolic products, such as direct bilirubin and urea. In addition, decreased glucose levels. Introduction of cytoflavin approached the control values the basic biochemical parameters of liver function: decreased hyperenzymemia, exchange function of the liver was restored, which is probably due to antihypoxic, membrane and antioxidant effects of the drug.

Subjects of the study were 100 chronic abdominal pain syndrome inpatients assigned to subgroups of different level of significance of psychological factors for the development of pain syndrome, different self-assessed pain level (utilizing visual analog scale), and different type of attitude towards disease (by the Bekhterev Institute Personality Inventory). Character and psychodynamic specialties were assessed in the aforementioned subgroups following to assignment. Proved by clinical and psychometric methods diagnosis of somatoform pain disorder was used as an indicator of high importance of psychological determinants. Differences between subgroups were assessed by the kit of questionnaires (Beck Depression Inventory, Spielberger Anxiety Scales, Wasserman Social Frustration Inventory, TAS, MCMI-III) and projective tests (Luscher and Szondi tests). Interference between psychosomatic and demographic characteristics within the sample, and accuracy of assigning subjects to subgroups were discussed. Interpretation of the acquired data with implications for psychotherapists was offered.

Original method of nonneoplastic tracheoesophageal fistula disjunction using compression construction with shape memory has been developed. The experimental study was performed on mongrels with preliminarily made tracheoesophageal fistula. The technique consists of fistula covering with pedicle fat flap and following clipping by the construction. In all cases tracheoesophageal fistula was eliminated simply and reliably. Macro- and microscopic investigation of intervention area revealed, that continuity of typical epithelium of trachea and esophagus was regenerated by the 14 day after operation.

It is shown that the process of establishing the equilibrium concentration of ions is exponential. But very small value of exponent leads to the fact that the ion concentration practically does not change at all reasonable times the values of diffusion, the possible changes as it lies within the experimental error of measurement.

The variant anatomy of saphenous veins of forearm in the zones of venous flap rising remains unstudied yet, as well as the influence of the valve apparatus of saphenous veins on the arterial perfusion of venous flaps. The paper studies the variant anatomy of saphenous veins of the upper third of the volar surface of forearm. Two versions of saphenous veins are revealed: major (axial) and retiform. It is found experimentally that the valve apparatus of saphenous veins does not influence considerably the arterial perfusion of venous flaps of forearm.

The results of investigation of the corrected medicinal form on the base of common tansy flowers in this article are represented. The optimal base — syrup of sugar and corrective (composition «orange») was chosen. Some physical-chemical data (capacity, chemical compound, refraction data) are shown.

The review discusses problem of organization and storage of associated information for biological collection. Basic principles of database structure development are presented. Databases for biological collections and biobanks in Russiaand other countries are reviewed. Structure of database of Biobank of Institute of Medical Genetics SB RAMS is described.

The paper is devoted to the problem of medical errors in diagnosing. With the Siberian clinical school taken as an example, the theory of formation of clinical experience from the gradual accumulation of experience by the school founders to the active formation of clinical thinking through the use of the theory of diagnosing is presented.

The absence of reliably functioning small-diameter vascular grafts for coronary artery bypass graft surgery remains one of the most important issues of cardiovascular surgery. Tissue-engineered grafts have to be characterized by highly hemocompatible, biomechanical and biocompatible properties, be quickly biodegradable and have non-toxic degradation products. This article presents polyhydroxyalkanoate and policaprolactone main characteristics and evaluates their potential use as polymers for producing vascular grafts. Biocompatibility, good physical and mechanical properties of these polymers and their better performance in copolymer scaffolds were demonstrated.

To improve the results of treatment of patients with cholelithiasis and its complications, the comparative analysis of the frequency, causes, and character of biliary dust damages at traditional cholecystectomy and laparoscopic cholecystectomy and the results of reconstructive and restorative operations has been carried out. Among 6013 operated patients, duct traumas were observed in 0.6% at traditional cholecystectomy and in 0.7% at laparoscopic cholecystectomy. Based on the analysis of 56 repeated operations, the optimal tactics of treatment depending on the level and character of duct damages was determined. Prophylactics consists, first of all, in the early and adequate surgical treatment of patients with cholelithiasis.

In 17-year cohort p1rospective study, the dynamics of arterial hypertension (AH) and arterial pressure (AP) levels has been examined as functions of the boy mass. The cohort included 630 men and 916 women aged from 20 to 59. The overweight was diagnosed at the Body Mass Index index no lower than 25 kg/m².

In the primary research, the AH prevalence rate was 35,7% among overweighted people and 12,5% (р < 0,001) among people with normal weight. In the 17-year observation, the increase of the body mass up to overweight was accompanied by an increase in the AH rate and AP levels, while the decrease of the body mass down to the normal one was accompanied by a decrease of these indices (except only for men aged from 40 to 59). Among overweighted people revealed at the I and II stages of the study, the systolic ((155,71 ± 28,59) mmHg) and diastolic ((93,68 ± 13,77) mm Hg) AH was higher than that in people, who became overweighted the observation: (137,08 ± 23,02) and (86,73 ± 12,19) mm Hg, respectively (р < 0,001).

The information on the largest gastroenterology resort of Germany Bud Kissingen is presented. The main medical factor of a resort is external and especially internal application of mineral waters. With medical objective Bud Kissingen uses seven sources. The information on history of opening, structure of water of sources, the basic places of interest, medical means of a resort is given.

The aim was to study the efficiency of group chronophysiotherapy of patients with motor defects of gall bladder living in the West-Siberian region.

The analysis of the obtained results indicates that the combined physiotherapy of patients with  gall-bladder dyskinesias with the use of the group chronobiological approach favors the improvement of the functional status of the biliary excretion system with normalization of indices of the contractile function of gall bladder and the increase of organism adaptability without their stress.

In our study 45 patients with different focal liver lesions (110 nodules) were examined using high field MR-system (1,5 T). During this investigation quantitative MRI analysis of dynamic enhancement of various hepatic lesions and parenchymatous organs of abdomen were performed. It was shown that quantitative evaluation of enhanced MRI improves understanding of vascular transformation processes in pathologic hepatic focuses and in liver itself that is important for differential diagnoses of these diseases.

Complex clinical-biological investigation has been conducted in 25 patients with exogenous organic disorders and 30 mentally and physically healthy persons. Influence of the metabolic cerebroprotector cortexin on indices of oxidative stress in dynamic of the pharmacotherapy has been investigated. It has been shown that cortexin increases clinical efficacy of complex therapy of patients and exerts positive influence on indices of homeostatic systems. Action of cortexin on indices of the oxidative stress is characterised by normalisation of the processes of peroxide oxidation of lipids in erythrocytes and in serum

This paper presents the results obtained by the investigation of morphological condition of a gastric mucosa and serum concentration of pepsinogen-I, pepsinogen-II, and gastrin-17, as well as H. pylori IgG antibodies using «Gastropanel» test system when examining patients suffering from a duodenal ulcer combined with bronchial asthma. It was reveled that the level of serum concentration is in close relation to gastritis activity and Helicjbacter pylori bacterization in the gastric mucosa, thus expanding the «Gastropanel» test system application for diagnosing not only atrophic gastritis, but also for helicobacter gastritis without evidence of atrophy.

The results of 112 transpositions of blood receiving complexes tissue foot applied in the treatment of chronic posttraumatic osteomyelitis of the bones of the foot and the distal third of the shin. Positive results were obtained in 86,6% of patients with recovery to work in 81,5% of the patients. The authors argue that the proposed blood receiving complexes tissue foot in the treatment of chronic posttraumatic osteomyelitis of the bones of the foot and the distal third of the shin allow to depart from the practice of multistage operations, reduce the time of hospital treatment. The algorithm for help in the treatment of chronic posttraumatic osteomyelitis of the bones of the foot and the distal third of the shin.

We have shown that the classical panretinal laser coagulation is a rather traumatic procedure, damaging all layers of the
retina, leadingbto a narrowing of visual fields and decrease the electrical activityof the retina that can impair quality of life. Using sparing laser coagulation is a highly effective metod of prolonged of visual function.

One of the marked tendencies in the last time is the development of medical networks. The experience of Doctor Bormental network of medical centers dealing with overweight therapy indicates that now this structure is optimal; it most efficiently combines the high-quality medical care for patients and the economic efficiency of medical business.

The state of health, vegetative homeostasis and parameters of local immunity 104 first-graders at the age of 6—8 years in adaptation to training in educational institutions of the general type and with the raised academic load is studied. It is shown that the current of adaptable process of the first-graders trained in educational institutions of new type is interfaced to growth of a chronic pathology, infringement of a vegetative homeostasis and a condition of local immunity of mucous membranes (maintenance increase sekretori immunoglobulin A, activity decrease kaspazy-3 asaliva), testifying to decrease in nonspecific resistance of an organism of children.

The role of the professional factor in subjective satisfaction of the basic vital needs (by Mazhnikova N.V. et al., 2001) and frequency of an arterial hypertensia at 791 workers of the enterprises and establishments was studied. It is shown that conditions of labor activity cause distinctions as the general, and separate types of satisfaction of requirements that associates with various level of frequency of an arterial hypertensia.

Chair of Pathologic Physiology with Clinical Pathophysiology Course of the OmskStateMedicalAcademyhas celebrated its 90^th anniversary with the latest achievements in the pathogenesis of postresuscitation disease. Experimental resuscitation model exploited by the staff of the Chair is allowed to extend knowledge in respect to the nature of hemodynamic disorders, endogenous toxemias, functional and metabolic aspects of hypoxia and reoxygenation in terminal and critical states including other significant problems of the pathology. The Chair of Pathologic Physiology is going on with the scientific inquiries in close collaboration with the Clinical Chair of the Academy and Research Units of Russia.

Provided scientific biography of the founder of the Museum of human anatomy and the first Professor of normal Anatomy of the ImperialTomskUniversity N. Maliyev.

A 120-years history of the Dermatovenerology Chair of SibirianStateMedicalUniversityis presented. The contribution of the scientists into the theory and practice in dermatovenerology and traning of specialists is described. The advances of the last 10 years are shown.

The creative biography of Professor V.I. Perveyev, prominent Russian scientist, head of Traumatology, Orthopedy and Field Surgery Chair of Siberian State Medical University is presented. The main trends of scientific and public activity are concerned.