The article is dedicated to the 120th anniversary of the foundation day of the Department of General Pathology (Pathophysiology) of the Imperial Tomsk University - Tomsk Medical Institute - Siberian State Medical University and scientists whose scientific and pedagogical activity as well as career paths are connected with the Department and Tomsk Cathedral Scientific School of Pathophysiologists, one of the oldest schools in Russia and the first one in the Asian part of Russia. Main directions of school's scientific and research work of the past years are described in the article as well as its present day achievements in science. Special attention is paid to the activity of the head directors and the best representatives of the Tomsk Pathophysiological School such as P.M. Albitsky, A.V. Reprev, D.I. Timofeevsky, P.P. Avrorov, A.D. Timofeevsky, L.F. Larionov, D.I. Goldberg, E.D. Goldberg, V.S. Lavrova, who made a significant contribution to the development of the Russian medical science and medical education. The data on the leading scientific school of the Russian Federation under the leadership of the RAMS Academician V.V. Novitsky is presented in the article.

The aim of this study was to reveal the features of association polymorphisms of interleukin-1 IL-1 and the antagonist of receptor for interleukin-1 IL-1Ra gene polymorphism in Mongoloids and Caucasoid from Khakassia with HP-associated gastroduodenal pathology (chronic gastritis and gastric ulcer). It was revealed that among Khakasses the most widespread genotypes among Khakasses are СС IL-1β and R4R4 IL-1Ra. The association of СС +3953 and R2R3 genotypes with GU risk in Caucasoids was found.

Interferon system plays a key role in the antiviral response. Based on data from the literature, the most dangerous for the development of infectious diseases is the combination of risk alleles of several genes. This study focuses on the analysis of the combined effect of single nucleotide polymorphisms of interferon system genes OAS1, OAS3, PKR, IFNA17 and IFNG in the predisposition to chronic viral hepatitis C. It has been shown that the accounting of several risk genes improves the prediction of development of this disease.

The complex immunologic estimation of inflammatory reactions in bronchial contents at 30 patients with various phenotypes of a serious bronchial asthma is spent. It is established that the population structure of lymphocytes and cytokines a profile of the induced phlegm reflects expression and character of inflammatory disturbances in respiratory tracts that will allow to use the given non-invasive method for revealing of molecular markers of serious forms of a bronchial asthma. At the serious terapevticheskirefractory form of a bronchial asthma «brittle» a phenotype in respiratory tracts total СD4+ -, СD19+ -cell and concentration interleukina-4 against depression interleukina-10 is enlarged. At the serious form of a bronchial asthma of a phenotype «the chronic asthma with the fixed bronchial obstruction» in a bronchial secret prevails CD8+ -lymphocytes, concentration interleukina-8, the transforming growth factor-β increases.

The results of joints's magnetic resonance imaging of 10 patients with severe form of hemophilic artropathy are discussing in this article. The purpose of research was to study the state of soft tissue and bone intraarticulare's structures in present group of patients. The form of bones, condition of an articulate cartilage, the joint’s tendons and ligaments, synovium, presence of an intraarticulate exudate, presence and extent of adjournment haemosiderin, and also signal characteristics of a marrow were estimated.

There was carried out a research of the development of oxidative stress, the condition of glutathione dependant system of antioxidant protection in adipocytes of epididymal adipose tissue of rats when injecting alloxan. The development of oxidative stress in adipocytes was characterized by the increase of lipids hydroperoxide concentration, products reacting with thiobarbituric acid, and the increase of carbonylderived protein. Redox-condition in adipocytes was considerably changing that was specified by the decrease of the content of the reduced form of glutathione and tendency to the increase of glutathione disulfide content, decrease of ratio between reduced and oxidized forms of threepeptide. Damage of protein molecule at oxidative stress may lead to the abnormality of transduction of insulinic signal and appearance of insulin resistance in adipose tissue.

After unitary and repeated intravenous application magnetite is shown their distribution in organism of a rat by method of magnetic resonance imaging. Accumulation of particles in a liver and a spleen of animals is shown. We studied intracellular activity main enzymes of hepatocyte and nephrocyte rats in various periods after intravenous application of nanoparticles magnetite by histochemical method. Intravenous application of magnetite is accompanied change of energetic and plastic metabolism of studied cells.

The flow cytometry analysis of human peripheral blood monocytes separated by a two step density gradient centrifugation is reported. The expression of mRNA level of adenosine receptor (AdoR) subtypes (A1, A2A, A2B and A3) and interleukin 6 (IL-6), interleukin 8 (IL-8) and vascular endothelial growth factor (VEGF) in monocytes were determined using real-time PCR. We found considerable variation across individuals in mRNA expression levels of paracrine factors after the stimulation of adenosine receptors. Our findings suggests the role of adenosinergic system accounted for interindividual differences in monocyte activation.

Method of postresection pericardial defect closure using fabric implant on basis of nanostructural nikelide titanium fiber has been developed and tested on ten mongrels. Morphology of reclaim generated after pericardial reconstruction using fabric implant was studied. A new generated tissue has been shown to extend through implant and form single tissue reclaim, which keeps anatomico-physiological restoration of pericardial defect.

A calculation and ultrastructural analysis of cellular elements in the periodontal ligament premolars with different surfaces (medial, distal, buccal and palatal) and at different levels of the roots. It is shown that the biomechanical load on the morphology of the premolars periodontal changes throughout the root, depending on the location of zones of compression and tension. Content of cells in the periodontium depends on the surface and the level of the tooth root.

The electret voltage indices of artificial surfaces are dependent on coatings formation technology and may be regulated by means of change in their physical-chemical parameters. Chemical modification of radio frequency magnetron calcium phosphate coatings (RFMCPC) by means of silicious incorporation led to an augmentation of pieces’ electrostatic potential. A complication of RFMCPC relief that was fixed by roughness index Ra is accompanied by increase in electret voltage index of artificial surface and its statistical deviation. Bone marrow cells suspension in model biological electrolyte populated RFMCPC dimples. In this manner it modulated the amplitude and leveled out the differences of surface electrostatic potential.

«Renal» blood supply sources of adrenals in the norm are studied in the work as well as blood supply peculiarities of unilateral adrenal and kidney in renal artery stenosis are revealed. It is concluded that including the study of adrenal arteries into angiographic algorithm in case of renal artery stenosis is of necessity.

In experimental type 2 diabetes mellitus, caused in rats with streptozotocine intraperitoneal injection, the nettle and galega water extracts decrease, burdock extract increases the postprandial triglycerides level, nettle extract decrease the summary blood content of very low density and low density lipoproteins. The dandelion extract doesn’t change the disturbed blood glucose and lipid content.

An attempt is undertaken to show the specific character of general methodological principles of hypothesis validity in clinical diagnostics.

In this review we discuss the mechanisms of human immune response modification by helminth in bronchial asthma. Helminth invasion causes increase of level to regulatory T-cells and to suppression of an allergic inflammation in bronchial asthma. Antihelminth therapy leads to decrease of level Treg cells. Deficiency or dysfunction of Treg cells can be a cause of allergic diseases.

The оptimum realization to respiratory function depends on varied sensory feedbacks from ensemble of the sources of the body. Pulmonary sensory receptors are the initiating sites for lung reflexes. The information arriving from lungs and airways information is one of the most important feedbacks that provide the adaptation of the respiratory centre for producing of the pattern optimal in terms of work and force of breathing. In article the review of currently existing data about morphology and functional characteristics of sensitive pulmonary structures is presented: slowly adapting stretch receptors, rapidly adapting receptors, C-fiber receptors and neuroepithelial bodies.

We studied pulmonary hemodynamics and right ventricular diastolic function in 300 healthy children and 392 children with chronic bronchopulmonary pathology in an isometric exercise. Using echocardiography were determined systolic, diastolic, mean, pulmonary artery pressure, total pulmonary resistance, diastolic function of the right ventricle. Defined normal values of reactivity of pulmonary hemodynamics and diastolic function of the right ventricle in an isometric load. In patients with chronic bronchopulmonary pathology set higher increase of systolic, diastolic, mean, pulmonary artery pressure, decrease diastolic reserve the right ventricle compared to the control. The worst violations of pulmonary hemodynamics and diastolic function of the right ventricle during isometric load observed in patients with chronic Infectious-inflammatory and interstitial lung disease.

The purpose of the current research is to investigate the diagnostic value of ultrasonography of the pediatric gastroesophageal reflux disease. There were 29 children examined with clinical and endoscopic signs of gastroesophageal reflux in each of three age categories: less than 1 year, 1—6 years, and 7—14 years. The examination of abdominal esophagus, stomach and duodenum was conducted with the ultrasound scanner Ultrasonik. The abdominal esophagus was measured from its entrance into the diaphragm to the base of gastric folds. We also measured the diameter of esophagus, the width of lumen, thikness and structure of wall, and the His's angle. The most freqent symptoms of gastroesophageal reflux were the enlargement in diameter of esophagus and the thikening of abdominal esophagus wall, which were observed in 75,9% and 82,8% of cases correspondingly. It was noted that the enlargement of abdominal esophagus lumen happens on an empty stomach and after exercising in water in 44,8% of cases. 37,9% of children with gastroesophageal reflux have His's angle of 90 degrees. Gastroesophageal reflux was registered in 27,6% of cases. If children ranging in older age have enlargement in diameter of esophagus and the thikening of abdominal esophagus wall, it is the evidence of the incompetence of cardia and reflux esophagitis. Neonates with the syndrome of posseting are observed to have insignificant extention of abdominal part of esophagus (equal to 6—7 mm), it may be regarded as morphofunctional immaturity of lower esophagus sphincter.

The cardiointervalography method was used to study adaptation possibilities of students with vascular heart diseases and diseases of musculoskeletal system going to exercise therapy. The physical training organization with use exercise therapy favors the adaptation and functional reserve improvement, and the effect is more in 1st year study students with vascular heart diseases.

Management of otitis media with effusion is a challenging problem in view of its high prevalence and frequent complications in the form of stable hearing loss. High frequency of secondary immunodeficiencies in ENT diseases dictates the necessity of immunocorrection in combined treatment. Dinamic pure tone audiometry, tympanometry and subjective response demonstrated higher treatment efficiency in the «Gepon» groups.

The surgery results analysis of 615 patients with various thyroid disorders was carried out. The percentage of postoperative hypoparathyroidism amounted 1,14%. In order to prevent postoperative hypoparathyroidism in the course of experiment, the method of endovascular autotransplantation of accidentally removed or deprived of supply parathyroid glands was developed.

There are studied frequency of abscesses of a liver at chronic opistorchosis; the reasons of cases; features of clinic, diagnostics, treatment. Laboratory, morphological, instrumental and clinical methods were applied. From 1 170 patients operated concerning complications chronic opistorchosis, liver abscesses are taped at 31 (2,6%) with a long and massive invasion. In 90,5% of cases they were cholangiogenes. The clinic was charactericed by a septic condition. At ultrasonography it is taped two types of the image: corresponding stages of infiltration and a parenchyma destruction. Surgical tactics is individual: at 6 patients — transcutaneum drainage, at 12 — drainage by Melnicov, at 13 — a liver resection. Necessarily external drainage of biliar ducts. 4 persons were died. Features: 1) abscesses in most cases are plural; 2) good effect from concervative treatment at the kept passage of bile; 3) propensity to relapse.

During examining endoscopic sphincterotomy difficulties to be discovered that the small papilla of Vater cause technological problems of identification common bile duct orice. The best way to overcame that difficulties is performing of of hepar bile ductes punction with endoscopic common bile duct orice identification.

For the determining of the role of clinical data and integral laboratory indices in the valuation of endogenic intoxication (EI) in chronic hepatitis B (HHB) 100 patients and 20 healthy adults were examined. The present symptoms of the disease and the facts about the character and communication of somatic diseases were studied and the effective concentration of albumin (ECA) and the reserve of albumin binding (RAB) were defined by fluorescence method twice at 18—20 days interval. The lowering of average indices of ECA and RAB was revealed in HHB patients in comparison with control group (p < 0,05), and this lowering was stable during the treatment. ECA and RAB levels reducing was more marked in HHB patients with negative changes of acute infectious diseases character and in patients with definite chronic somatic diseases in comparison with the opposite groups (p < 0,05).

Comparative evaluation of hepatoprotective properties of polyphenolic fraction from wood (Maksar) and a polyphenolic complex of cell culture of Maakia amurensis.

Therapeutic efficacy of the objects was assessed by their effect on the MR tomographic performance of the liver of rats with experimental СCl4-hepatitis. Hepatoprotective activity of polyphenol complex cell culture Maakia amurensis is not inferior to the original effect of the drug Maksar.

This article presents the comparative analysis of humoral and cellular immunity indicators under the influence of magneticlaser effect in 2 frequency ranges (150—1 5000 Hz) for treatment of pregnant women with mild anemia against the background of chronic gastritis, associated with contamination gastrointestinal tract Helicobacter pylori. The application of magnetic-laser effect in frequency 150 Hz allows to raise of hemoglobin lowers the titre of antibodies to Helicobacter pylori. The moderate stimulation of Th1 link withoit activation of humoral immunity is optimal in treatment of benign anemia of pregnancy.

Nowadays the great attention is paid to problems of construction of efficient system management. Toward this end, we have considered the following aspects of the activity, which allow us to characterize the management system in general: evaluation of the existing management system, evaluation of the degree of formalization of the management system, and evaluation of the customerorientation index. Management approaches were evaluated comparatively using pharmacy network as an example. It has been shown that implementation of new technological management approaches enhances the organization potential.

In 17-year prospective cohort study, we analyzed the influence of smoking and drinking on the formation of cardiovascular and general mortality of adult people in Tomsk. The cohort included 1 546 people (630 men and 916 women) aged 20—59 years. It has been found that due to smoking the 17-year risk of death by any cause increases 2.4 times among men and 2.7 times among women. The increase in the frequency of drinking in the male population increase the risk of death by any cause 1.6 times (for men drinking once a month or more rarely), 2.4 times (for men drinking once a week and more rarely, but more often than once a month), and 3.8 times (for men drinking more often than once a week). The risk of death by cardiovascular diseases increases 1.7, 2.9, and 4.9 times, respectively.

In experiment on laboratory rats Wistars by a method of appearing through electronic microscopy of a liver it is established, that at action of small doses of fluorine (0,5 mg/kg of a fluorine-ions within 1 month) hepatocitys are exposed destructions by damp lyses, and endoteliocitys — apoptosis. A special kind destructions is migration mytochondris in kernels hepatocitys with the subsequent formation megaautohpagosomes and them lyses. In basalition to a membrane develops fibrosis and appear pathological message between space Disse and a gleam of sinusoidal capillaries. The conclusion that small doses of fluorine close to used at osteoporosis correction, cause destructive changes in a liver that does necessary to carry out the actions directed on inactivation of fluorine becomes.

Freudian concept of deviating behaviour’s context is considered how duality in understanding of the person’s nature with primate of Lüstprinzip and Tanatos to social and cultural base brings about to certain justification of human behaviour’s deviations. And even disgruntles the culture. The Temptation of deviations is concluded in following. Than is call in question social explanation of deviating conduct.

A 120-year history of the children diseases Department of Siberian State Medical University is presented. The contribution of the scientists into the theory and practice in pediatrics and training of specialists is described. The advances of the last decade are shown.