Research objective was establishment of ultrastructural changes of mucous membrane maxillary sinus (MM MS) at noninvasive and chronic invasive aspergillosis. By methods of light, electronic microscopy and morphometry it is established, that the basic signs of endocellular reorganisation of epithelial cells at noninvasive form are decrease in squirrels-synthetic and plastic functions. On separate sites of epithelium there are the cages characterised small changes by cytoplasmatic organells. As a whole, the revealed changes testify to loss of epithelium protective and barrier properties, and as consequence, its defective participation in mucocilliar clearance. At invasive form of aspergillosis sinusitis, despite revealed single-layered metaplasia, in epithelial cells was observed fiber-synthetic and plastic processes that can specify on high reparative possibilities of epithelium.

In the experiment in vivo we studied the regenerative course after intraorbital implantation of porous titanium nickelide impregnated with autologous blood monocytes and without them after evisceroenucleation. It was revealed that introduction of autologous blood monocytes stimulates the growth of collagen fibers and new vessels, accelerates the process of regeneration and formation of orbital stump.

Because of the shortcomings of existing methods of assessment of inflammation activity in the airways, the method of laser optic-acoustic spectroscopy of patients expired air considered using for this purpose. This method can be used to indirectly evaluate the activity of inflammation in the airways and as an additional criterion for the effectiveness of basic treatment in patients with asthma.

The aim is analysis of EEG-rhythms spectral capacity during biofeedback session by heart rhythm variability (HRV) parameters in dependence from serum serotonin level. The were surveyed 53 girls 15—17 years of Arkhangelsk. The girls with a deficit of serotonin to achieve positive results biofeedback-training is accompanied by desynchronization EEG components, which results in reduced spectral power of EEG α-, β- and θ-activity. At the level of serotonin in the blood serum in the normal range for girls is an increase in spectral power of α-activity in thethe anterior parts of of the brain.

In experiment in vivo laws of regeneration of damages of a cornea on background intrastromal introductions of autologus mononuclear blood are studied. It is proved, that local application of mononuclear cells significantly reduces the duration and expressiveness of inflammatory process and as consequence, is accelerated process of regeneration of the damaged corneal tissue.

The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with plasma ACE, renin activity and endothelial function of skin microvassals were studied. Preeclamptic patients with the DD genotype of ACE I/D gene polymorphism have lowest plasma renin activity level and endothelium-dependent vasodilatation, D allele carriers have highest plasma ACE activity.

The research objective consisted in current studying puberty the period at boys with type 1 diabetes. Boys have entered into research 11—18 years. The estimation of physical, sexual development, a lipid and hormonal spectrum was spent; ultrasonic research inguinal and scrotal areas were estimated. Prolongation of early stages of puberty was marked, in 9,4 % of cases the delay of sexual development is revealed.

Knowledge of the ileocecal anastomosis of the intestine are of great practical importance. Therefore, the aim of our study was to examine circulation ileocecal obturator apparatus. The study was conducted on 30 samples of ileocecal angle by a liqueur a. ileocolica 3% solution of gelatin with black ink, and further dissection artery and its branches. Anastomoses mesenteric arteries were studied using the technique transillumination under a beam of directed light. Artery ileocecal valve were studied using mikropreparovki with forehead binocular microscope with an increase in x3. The study identified an additional anastomoses with the anterior cecal artery, and also showed that blood flow to the lips bauginievoy damper is closed around the ostium ileocecale arterial ring.

For improvement results of the treatment of children with chronic osteomyelitis author offers to put into practice more frequent control examinations of patients and definition direction of the current of local pathological process with help elaborated the prognostic table. At the same time are recommended different variants of treatment and rehabilitation until the patient be under observation.

Large-scale deformations of a homogeneous sphere and a cylinder obeying Hooke’s law were considered. It was shown that under certain conditions the deformations acquire catastrophic character. The magnitude of pressure and strength properties of vessels at which the deformations are bootsing at high rates were estimated.

In spite of the fact that at present exists quite a few operative methodses, directed on reconstruction of insolvency lieocecal valve, united opinion, for functions given division of the bowels no. The aim of our study was to examine the biomechanics of the closer abilities of ileocecal valve, according to deep study of the anatomical forming the area ileocecal junction. In the course of studies was installed that in rate deskside ileocecal junction, external ligaments, pleats of the wall of the caecum, original musclearchitectonic, as well as geometry of the lips Bauhin’s dampers, play the important role in mechanism of the closing ileocecal valve.

Score mRNA expression and the level of Hsp27 (Heat shock protein 27) and phospho-Hsp27 in tumor cell line Jurkat and THP-1, as well as in mononuclear leukocytes obtained from healthy donors was investigated. In tumor cells, Jurkat and THP-1 Hsp27 plays the role of inhibitor of apoptosis, by influencing the ratio of antiapoptotic (Bcl-2) and proapoptotic (Bax and Bad) proteins.

Renal blood supply sources of adrenals in the norm are studied in the work as well as blood supply peculiarities of unilateral adrenal and kidney in renal artery stenosis are revealed. It is concluded that including the study of adrenal arteries into angiographic algorithm in case of renal artery stenosis is of necessity.

The enhancement of physical education of students under conditions of humanization of education assumes, first, the organization of monitoring, which is a part of the education process and is oriented at the permanent observation, evaluation, analysis, and correction of this process and its results. Second, the results of the monitoring are the starting point for the projection, formation, and correction of the education process through the change of its conditions such as the introduction of differentiation in the need in students’ sport exercises and level differentiation in the degree of formation of motivation to exercises, methodic and physical efficiency. The gathering of combined information about indices of physical education of students will allow the optimization of the efficiency and correction of used physical education programs.

Atopic dermatitis — is a chronic disease, with immune mechanisms leading to high level of immunoglobulin Е and abnormal skin reactivity. The current review is presenting the experimental and clinical study results regarding to Т-regulatory cells participation in atopic dermatitis immune response.

This article deals with a short analysis of intraoperative hemostasis in parenchymatous organs by the example of liver. A brief historical survey is given. The hemostatic sutures developed by different formers and the defects of hemostatic sutures are considered. There are some features of instrumental hemostasis, its advantages and disadvantages. The description of the new developed devices on basis of cold plasma, the hemostatic and antiseptic properties of the devices are presented.

The article presents up-to-date data on the functioning of the T-helper type 17 (Th17). History of the Th17 discovery, transcription factors, mechanisms, mediating stimulation and inhibition of the Th17 differentiation, are described. Cytokines, which are produced by this lymphoid subset, and signaling pathways, through which its effects are realized, are listed. A brief description is given of the main physiological processes and diseases, in which participation of the Th17 was described.

The purpose of this review was to analyze existing data in the literature research on some pathogenetic mechanisms of the Valsalva retinopathy development. The main causes of retinal vessel damage of vascular are described. They include arterial pressure and central venous pressure elevation. The latter is transmitted to retinal veins and may cause retinal capillar wall ruptur.

Until recent time it has seemed obvious that suppressive function in the immune system is provided by one subpopulation of Tlymphocytes-suppressors. At present it is usually considered that regulatory cells (T-reg) are key cells-suppressors of the immune response. There exist two main mechanisms of T-reg immunosuppression realization: direct (when there is direct contact between cells) and distant (cytokine-dependent). For suppression of the immune response Т-reg cells produce cytokines with suppression activity: TGF-β, IL-10, IFN-γ, IL-35. Meanwhile the increasing number of facts indicates that suppression of the immune response is a multi-component process. A considerable role in suppression of the immune response is assigned to the endocrine system. However, immunosuppression mechanisms under infection, neoplastic processes and the influence of xenobiotics on the organism are not completely clear.

The problem of parenteral viral hepatitis, in particular, viral hepatitis B (VHB), is urgent till now owing to some social, economic, and epidemiologic factors. The paper analyzes clinic-epidemiologic VHB indices in children for 1994—2009 in the Tomsk Region. The analysis includes 311 patients with acute and chronic VHB aged from 1 month to 18 years. The patients were treated in infectious hospitals of the city of Tomsk and Tomsk Region for the period of 1994 to 2009. Both clinic (short preicteric period, incomplete recovery after the normal hospitalization period) and epidemiologic (alternation of infection ways with time and their dependence on age, predomination of schoolchildren in the VHB age structure) VHB features are revealed.

Ethnofactors of chronic cardiac failure (CCF) include type 2 diabetes (D-2). The treatment of patients with diabetes and chronic cardiac failure is very problematic. The aim is to reveal the CCF prevalence rate among D-2 patients in a representative sample of respondents in Orenburg and to assess their treatment. Two groups of D-2 patients were analyzed: the first group consisted of unorganized urban population patients, and the second group consisted of hospital patients. The CCF prevalence rate in patients of the second group (78%) was quite comparable with that in the first group (82%). The analysis of efficiency of CCF treatment in the representative sample has shown that drug treatment was not sufficient from the cardiologist’s point of view. CCF complicates D-2 in most patients. The current therapy aimed at the correction of cardiovascular disorders in patients with diabetes and cardiac failure calls for optimization in accordance with national recommendations.

Respiratory distress syndrome infants — the most common pathology in preterm infants, as well as the reason for the formation of such chronic lung diseases as bronchopulmonary dysplasia. Possibility of using new research techniques, such as bronchophonography to assess functional changes in the respiratory tract and predict the outcome of BPD in preterm with RDS is quite promising. The article presents the results of a prospective cohort study of comparative parameters broncho-phonography in preterm infants with respiratory distress syndrome. Using the method of logistic regression, a mathematical model to predict the risk of bronchopulmonary dysplasia in this group of children. Determined that the most common form bronchopulmonary dysplasia premature, at which the probability of occurrence greater than or equal to 50%.

Differentiation of tumor recurrence from radiation-induced brain changes is the main challenge of neuroimaging in patients with treated cerebral tumor. The review presents the limitations of structural imaging and additional opportunities of perfusion imaging techniques, proton magnetic resonance spectroscopy and positron emission tomography in discriminating recurrent tumor from radiation injury.

Reflects stages of funnel chest treatment in the Tomsk Region from 1977 to 2009 has been presented. The work provides analysis of surgical treatment of 78 patients, including 42 patients were operated by means of thoracoplasty with the following fixation of costosternal complex using previously chilled titanium nickelide plates, which have thermodynamic properties.

The analysis of possibilities of forecasting of an arterial hypertensia depending on age and character of professional work of 607 women of mass trades is carried out. It is shown that groups of the raised and high risks of development of an arterial hypertensia make women is more senior 40 years, working in the trades characterised by physical work, and also brainwork.

The condition of cerebral hemodynamic at the patients who transferred a cervical trauma of a backbone during the early and intermediate periods was studied. Examined 48 patients at the age of 18—50 years with cervical injury of spine during the early and intermediate periods. Patients were grouped according anatomical particularizes of cervical cord injury and influenced at spinal cord. Besides neurologic inspection, methods of ultrasonic Doppler sonography extracranial and transcranial Doppler sonography of intracranial brain vessels. The most essential changes of a blood-groove were registered in vertebrobasilar pool in a group with a complicated inferior cervical backbone trauma (deficiency of a blood-groove on 30—32% from control group р < 0,05). At patients with not complicated inferior cervical trauma authentically changed only intracranial blood-groove on vertebralis arteries (decrease on 19—26% on the average; р < 0,05). Characteristic changes for patients with a cranivertebral trauma of hemodynamic have not been revealed. The cerebral hemodynamic during the early and intermediate periods was changed at the patients on severity lower level of a cervical trauma of a backbone.

The article contain the results of retinal detachment surgical treatment with help of the new method, lie on pneumoretinopexy with epiretinal introduction of the collalisinum and the transscleral removal of subretinal liquid into retrobulbar space. There is shown that, the introduced method in comparison with traditional extrasclearal operations, is defined less traumatic, makes for stable clinical and functional results in the postoperational period and permits to reduce the number of complications, including the retinal detachment relapse.

Study of the ursosan therapy influence on the efficiency of the surgical resolution of cholestasis in the early postoperative period on the bile-excreting tracts. 19 healthy people and 24 patients with organic abnormalities of the drainage function of the bile ducts are examined. The analysis of the clinical, laboratory and instrumental criteria of cholestasis is carried out in the tested groups before and after ursosan’s therapy and the surgical treatment. Ursosan’s prescription leads to 3 times increase of cases of full regression of clinicolaboratory markers of cholestasis during the first week of the surgery on the bile ducts. The ursosan’s therapy should be prolonged more than 8 days after operative restoration of the bile passage on the bile ducts considering high level of lithogenic factors of C bile on these patients as compared to healthy people. The criteria of the completed ursosan’s therapy can be the normalization of the conjugated bilirubin level in the serum and or relief of slagging effect according to the ultrasound results of the bile ducts and a gallbladder.

The article reflects principles of surgical treatment of keeled chest. It describes an operative approach depending on the deformity kind. The work provides analysis of surgical treatment of 26 patients. There were presented main stages of new technique, which supplement the “classical” kind of surgical intervention. It was noted that using titanium nickelide plates with the shape memory to correct keeled chest in children and adolescents is the method of choice and brings good clinical results.

The results of comparative analysis of the efficiency between different sorts of the age-related macular degeneration treatment wet form has been presented in the article. There was demonstrated that choosing the treatment tactics in such pathology patients used to consider the clinical form and the stage of the disease. The wet form needs pneumoretinopexy with following of retina laser coagulation. The subretinal fibrovascular membrane is indications for transcilliary vitrectomy with removal of proliferate tissue. The traditional medical treatment of wet form of age-related macular degeneration does not ensure stable clinical and functional results.

Problems of aged population mortality lead to massive increase in total expenses on health service. Stability of mortality rate was primary cause of population type in Omsk Region was estimated as regressive. It was high level of demographic old age in the region, death rate at the age of 60—70 remain high. Record of tendencies of mortality is one of the most important tasks of social policy.

The complex of medical aid arrangements for arterial hypertension patients in the rural and farthest areas of Irkutsk Region which were characterized by low accessibility of specialized medical aid was developed. The complex make possible to improve awareness, treatment and control of arterial hypertension.

Based on his own results and the latest literature evidence the author raises a point concerning the birth defects nosological forms and birth morphogenetic readings registration. Living hitherto in the literature conception differences regarding terms «birth developmental defects» and «birth morphogenetic variants» stipulate for the significance of varied approach in definition birth defect as developmental defects or as developmental anomaly taking into consideration the insight of distinction in these states. The author proposes the addition to the subsist in native literature term «birth developmental defects» Registration of birth defects according to the latest International Classification of Diseases with the register organization of all birth defects apart from the register of birth anomalies is specificated in the paper.

Subpopulation structure of regulatory T-cells of peripheral blood in patients with newly diagnosed pulmonary tuberculosis depending on the clinical form of disease and sensitivity of Mycobacterium tuberculosis to anti-tuberculosis drugs have been analyzed in this work. It has been shown that in formation immune suppression at infiltrative, dissemination and fibrosis-cavity pulmonary tuberculosis the leading part play natural regulatory CD4+ CD25+ Foxр3+ -T-lymphocytes. Thus increase of their number in blood at drug-resistance and drugsusceptible patients. It has been demonstrated that in patients with fibro-cavernous and infiltrative form of the disease and drug-resistance pulmonary tuberculosis the number of CD4+ CD25- Foxр3+ -regulatory T-cells were increasing.